ChemicalBook > CAS DataBase List > TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
CAS No.: 845267-78-9
Chemical Name: TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
Synonyms: 1-Boc-2, 4-piperidinedion...;N-BOC-2,4-dioxopiperidine;N-Boc-2,4-Piperidinedione;1-Boc-2,4-dioxopiperidine;N-Boc-piperidine-2,4-dione;1-Boc-piperidine-2,4-dione;1-Boc-2, 4-piperidinedione;Piperidine-2,4-dione, N-BOC protected;TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE;1,1-Dimethylethyl 2,4-dioxopiperidine-1-carboxylate
CBNumber: CB62454122
Molecular Formula: C10H15NO4
Formula Weight: 213.23
MOL File: 845267-78-9.mol

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TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Property

Boiling point:: 373.8±35.0 °C(Predicted)
Density: 1.199
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.67±0.20(Predicted)
form: powder
color: Yellow
InChI: InChI=1S/C10H15NO4/c1-10(2,3)15-9(14)11-5-4-7(12)6-8(11)13/h4-6H2,1-3H3
InChIKey: SLCAHLSQXDNQSF-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)CC1=O

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Safety

Risk Statements: 20/21/22
Safety Statements: 23-24/25
WGK Germany: 3
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00033
Product name: 2,4-Dioxopiperidine-1-carboxylic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

Usbiological

Product number: 263936
Product name: N-Boc-2,4-piperidinedione
Packaging: 5g
Price: $644
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB33566
Product name: N-Boc-2,4-piperidinedione
Packaging: 50g
Price: $700
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0167369
Product name: N-BOC-2,4-PIPERIDINEDIONE
Purity: 95.00%
Packaging: 1G
Price: $826.98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB33566
Product name: N-Boc-2,4-piperidinedione
Packaging: 100g
Price: $900
Updated: 2021/12/16

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TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

tert-Butyl 2,4-Dioxocyclohexanecarboxylate is a reactant in the synthesis of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor.

Synthesis

2033-24-1

3303-84-2

845267-78-9

Step ii: Synthesis of tert-butyl 2,4-dioxopiperidine-1-carboxylate To a 250 mL round-bottomed flask was added 3-((tert-butoxycarbonyl)amino)propanoic acid (4 g, 0.0211 mol), Meldrum acid (3.66 g, 0.0253 mol), 4-dimethylaminopyridine (3.92 g, 0.0316 mol) and anhydrous dichloromethane (100 mL). After the reaction mixture was cooled to 0 °C, EDCI-HCl (6.01 g, 0.0316 mol) was added to the same flask. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with 5% aqueous potassium bisulfate. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was dissolved in ethyl acetate (100 mL) and refluxed for 4 hours. The volatiles were evaporated under reduced pressure to give tert-butyl 2,4-dioxopiperidine-1-carboxylate (3.2 g, 71% yield). 1H NMR (300 MHz, CDCl3): δ 4.12 (t, 2H), 3.51 (s, 2H), 2.64 (t, 2H), 1.55 (s, 9H). LCMS: 211.9 (M-H)+.

References

[1] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 52; 53
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 14, p. 3594 - 3598
[3] Angew. Chem., 2014, vol. 126, # 14, p. 3668 - 3672,5
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 34, p. 7651 - 7657

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE manufacturers

Henan Fengda Chemical Co., Ltd

Product: tert-Butyl 2,4-dioxopiperidine-1-carboxylate 845267-78-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Career Henan Chemical Co

Product: TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE 845267-78-9
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10tons
Release date: 2018-08-04

845267-78-9, TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATERelated Search:

2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Tert-butyl 2-cyanopiperazine-1-carboxylate Butyl ester Butyl benzoate Formic acid DL-Pipecolinic acid COPPER(II) PHTHALATE Disodium edetate dihydrate sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate Tetramethrin 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE (3-OXO-BUTYRYL)-CARBAMIC ACID ETHYL ESTER TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE N-Boc-2-piperidone

1-Boc-2, 4-piperidinedion...

tert-butyl 2,4-dioxopiperidine-1-carboxylate(SALTDATA: FREE)

N-BOC-2,4-dioxopiperidine

tert-butyl 2,4-dioxopiperidine-1-carboxylate, 1-piperidinecarboxylic acid, 2,4-dioxo-1,1-dimethylethyl ester, 1-boc-piperidine-2,4-dione, N-Boc-2,4-dioxopiperidine, 2,4-dioxopiperidine-1-carboxylic acid tert-butyl ester, N-tert-butoxycarbonyl-piperidine-2,4-dione, t-butyl 2,4-dioxopiperidine-1-carboxylate

N-Boc-piperidine-2,4-dione

N-Boc-2,4-Piperidinedione

1,1-Dimethylethyl 2,4-dioxopiperidine-1-carboxylate

2,4-Dioxopiperidine-1-carboxylic acid tert-butyl ester

1-Boc-2, 4-piperidinedione

1-Boc-piperidine-2,4-dione

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

1-Boc-2,4-dioxopiperidine

Piperidine-2,4-dione, N-BOC protected

1-Piperidinecarboxylic acid, 2,4-dioxo-, 1,1-dimethylethyl ester

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE ISO 9001：2015 REACH

2,4-Dipiperidone-1-carboxylic acid tert-butyl ester

845267-78-9