TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
- CAS No.
- 845267-78-9
- Chemical Name
- TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
- Synonyms
- 1-Boc-2, 4-piperidinedion...;N-BOC-2,4-dioxopiperidine;N-Boc-2,4-Piperidinedione;1-Boc-2,4-dioxopiperidine;N-Boc-piperidine-2,4-dione;1-Boc-piperidine-2,4-dione;1-Boc-2, 4-piperidinedione;Piperidine-2,4-dione, N-BOC protected;TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE;1,1-Dimethylethyl 2,4-dioxopiperidine-1-carboxylate
- CBNumber
- CB62454122
- Molecular Formula
- C10H15NO4
- Formula Weight
- 213.23
- MOL File
- 845267-78-9.mol
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Property
- Boiling point:
- 373.8±35.0 °C(Predicted)
- Density
- 1.199
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.67±0.20(Predicted)
- form
- powder
- color
- Yellow
- InChI
- InChI=1S/C10H15NO4/c1-10(2,3)15-9(14)11-5-4-7(12)6-8(11)13/h4-6H2,1-3H3
- InChIKey
- SLCAHLSQXDNQSF-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(=O)CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- SYX00033
- Product name
- 2,4-Dioxopiperidine-1-carboxylic acid tert-butyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- 263936
- Product name
- N-Boc-2,4-piperidinedione
- Packaging
- 5g
- Price
- $644
- Updated
- 2021/12/16
- Product number
- FB33566
- Product name
- N-Boc-2,4-piperidinedione
- Packaging
- 50g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- CHM0167369
- Product name
- N-BOC-2,4-PIPERIDINEDIONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $826.98
- Updated
- 2021/12/16
- Product number
- FB33566
- Product name
- N-Boc-2,4-piperidinedione
- Packaging
- 100g
- Price
- $900
- Updated
- 2021/12/16
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
tert-Butyl 2,4-Dioxocyclohexanecarboxylate is a reactant in the synthesis of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor.
Synthesis
2033-24-1
3303-84-2
845267-78-9
Step ii: Synthesis of tert-butyl 2,4-dioxopiperidine-1-carboxylate To a 250 mL round-bottomed flask was added 3-((tert-butoxycarbonyl)amino)propanoic acid (4 g, 0.0211 mol), Meldrum acid (3.66 g, 0.0253 mol), 4-dimethylaminopyridine (3.92 g, 0.0316 mol) and anhydrous dichloromethane (100 mL). After the reaction mixture was cooled to 0 °C, EDCI-HCl (6.01 g, 0.0316 mol) was added to the same flask. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with 5% aqueous potassium bisulfate. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was dissolved in ethyl acetate (100 mL) and refluxed for 4 hours. The volatiles were evaporated under reduced pressure to give tert-butyl 2,4-dioxopiperidine-1-carboxylate (3.2 g, 71% yield). 1H NMR (300 MHz, CDCl3): δ 4.12 (t, 2H), 3.51 (s, 2H), 2.64 (t, 2H), 1.55 (s, 9H). LCMS: 211.9 (M-H)+.
References
[1] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 52; 53
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 14, p. 3594 - 3598
[3] Angew. Chem., 2014, vol. 126, # 14, p. 3668 - 3672,5
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 34, p. 7651 - 7657
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Suppliers
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View Lastest Price from TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE manufacturers
- Product
- tert-Butyl 2,4-dioxopiperidine-1-carboxylate 845267-78-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE 845267-78-9
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10tons
- Release date
- 2018-08-04