TERT-BUTYL-N-METHYLCARBAMATE
- Product Name
- TERT-BUTYL-N-METHYLCARBAMATE
- CAS No.
- 16066-84-5
- Chemical Name
- TERT-BUTYL-N-METHYLCARBAMATE
- Synonyms
- tert-Butyl methylcarbamate;N-Boc-methanamine;TERT-BUTYL-N-METHYLCARB;ert-Butylmethylcarbamate;Methylamine, N-BOC protected;TERT-BUTYL-N-METHYLCARBAMATE;(tert-Butoxycarbonyl)methylamine;N-(tert-Butoxycarbonyl)methylamine;1,1-Dimethylethyl N-methylcarbamate;Methyl-carbaMic acid tert-butyl ester
- CBNumber
- CB62459248
- Molecular Formula
- C6H13NO2
- Formula Weight
- 131.17
- MOL File
- 16066-84-5.mol
TERT-BUTYL-N-METHYLCARBAMATE Property
- Boiling point:
- 176.6±8.0 °C(Predicted)
- Density
- 0.937±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DCM, Methanol
- form
- Oil
- pka
- 13.04±0.46(Predicted)
- color
- Clear
- InChI
- InChI=1S/C6H13NO2/c1-6(2,3)9-5(8)7-4/h1-4H3,(H,7,8)
- InChIKey
- JHLVEBNWCCKSGY-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC
N-Bromosuccinimide Price
- Product number
- SYX00012
- Product name
- tert-Butyl-N-methylcarbamate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- B694020
- Product name
- tert-ButylMethylcarbamate
- Packaging
- 10g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- 467175
- Product name
- tert-Butyl Methylcarbamate
- Packaging
- 250mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- 4156-1-36
- Product name
- tert-Butyl methylcarbamate
- Purity
- 95%
- Packaging
- 100g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- CHM0118896
- Product name
- TERT-BUTYL-N-METHYLCARBAMATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $634.25
- Updated
- 2021/12/16
TERT-BUTYL-N-METHYLCARBAMATE Chemical Properties,Usage,Production
Uses
tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).
Synthesis
24424-99-5
74-89-5
16066-84-5
General method: Di-tert-butyl dicarbonate ((Boc)2O, 1.0 mmol) was mixed with monomethylamine (1.0 mmol) and the reaction was carried out with stirring at room temperature for the reaction time as shown in Table 1.The progress of the reaction was monitored by thin layer chromatography (TLC). In most cases, the purity of the resulting Boc-protected tert-butyl methyl-carbamate was satisfactory and no further purification was required. In a few cases, the products needed to be purified by silica gel column chromatography (eluent ratio: ethyl acetate/petroleum ether = 1:2). All products were characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and their physical properties.
References
[1] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246
[2] Journal of Organic Chemistry, 2016, vol. 81, # 11, p. 4566 - 4575
[3] Letters in Organic Chemistry, 2013, vol. 10, # 2, p. 121 - 125
[4] Patent: WO2008/33567, 2008, A1. Location in patent: Page/Page column 41
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 1994, vol. 34, # 2, p. 107 - 115
TERT-BUTYL-N-METHYLCARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL-N-METHYLCARBAMATE Suppliers
- Tel
- --
- Fax
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- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from TERT-BUTYL-N-METHYLCARBAMATE manufacturers
- Product
- TERT-BUTYL-N-METHYLCARBAMATE 16066-84-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-09-09
- Product
- TERT-BUTYL-N-METHYLCARBAMATE 16066-84-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 500kg
- Release date
- 2018-08-20