2,6-Dichloro-7-methylpurine
- Product Name
- 2,6-Dichloro-7-methylpurine
- CAS No.
- 2273-93-0
- Chemical Name
- 2,6-Dichloro-7-methylpurine
- Synonyms
- 2,6-DICHLORO-7-METHYL-7H-PURINE;106282;2,6-DICHLORO-7-METHYLPURINE;2,6-dichloro-7-methyl-purin;7H-Purine, 2,6-dichloro-7-methyl-;2,6-Dichloro-7-methyl-7h-purine ,98%;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);7H-Purine,2,6-dichloro-7-methyl，97% min;2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
- CBNumber
- CB6246923
- Molecular Formula
- C6H4Cl2N4
- Formula Weight
- 203.03
- MOL File
- 2273-93-0.mol
2,6-Dichloro-7-methylpurine Property
- Melting point:
- 195.5-196 °C
- Boiling point:
- 307.2±52.0 °C(Predicted)
- Density
- 1.76±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.04±0.30(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 2273-93-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D435240
- Product name
- 2,6-DICHLORO-7-METHYLPURINE
- Packaging
- 5g
- Price
- $800
- Updated
- 2021/12/16
- Product number
- D435240
- Product name
- 2,6-DICHLORO-7-METHYLPURINE
- Packaging
- 10g
- Price
- $1485
- Updated
- 2021/12/16
- Product number
- J99325
- Product name
- 2,6-Dichloro-7-methylpurine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 011007
- Product name
- 2,6-Dichloro-7-methyl-7H-purine
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- ND29030
- Product name
- 2,6-Dichloro-7-methylpurine
- Packaging
- 25mg
- Price
- $97.5
- Updated
- 2021/12/16
2,6-Dichloro-7-methylpurine Chemical Properties,Usage,Production
Uses
2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.
Synthesis
5451-40-1
74-88-4
2382-10-7
2273-93-0
A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield).
References
[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7
2,6-Dichloro-7-methylpurine Preparation Products And Raw materials
Raw materials
Preparation Products
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