ChemicalBook > CAS DataBase List > (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

Product Name
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
CAS No.
438190-29-5
Chemical Name
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Synonyms
SMI-4a;CS-2669;CS-1477;SMI-4a（b）;(Z)-SMI-4a;TCS PIM-1 4a;SMI-4a, >97%;SMI-4A; SMI4A;TCS PIM-1 4a, >=98%;SMI-4a TCS PIM-1 4a
CBNumber
CB62518905
Molecular Formula
C11H6F3NO2S
Formula Weight
273.23
MOL File
438190-29-5.mol
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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Property

Density 
1.530±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMSO: >10mg/mL
form 
powder
pka
7.38±0.20(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36-43
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0323
Product name
SMI-4a
Purity
≥98% (HPLC)
Packaging
10mg
Price
$118
Updated
2022/05/15
Cayman Chemical
Product number
11029
Product name
SMI-4a
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11029
Product name
SMI-4a
Purity
≥98%
Packaging
5mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
11029
Product name
SMI-4a
Purity
≥98%
Packaging
10mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
11029
Product name
SMI-4a
Purity
≥98%
Packaging
50mg
Price
$384
Updated
2024/03/01
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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Chemical Properties,Usage,Production

Description

SMI-4a (438190-29-5) is a selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases.1?Induces cell cycle arrest in leukemia and prostate cancer cells.2?Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive.3?SMI-4a is a useful tool for exploring the involvement of Pim in cellular signaling.4?Cell permeable.

Uses

SMI-4a is an aldose reductase inhibitor as well as a COX-2 inhibitor, a potential agent in the inhibition and treatment of cancer and cancer cell lines.

References

1) Xia et al. (2009), Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases; J. Med. Chem., 52 74 2) Beharry et al. (2009), Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells; Mol. Cancer Ther., 8 1473 3) Lin et al. (2010), A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma; Blood, 115 824 4) Zhang et al. (2009), PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells; Cancer Biol. Ther., 8 846

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Suppliers

Canada 1 China 99 India 2 United Kingdom 2 United States 22 Global 126
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione manufacturers

Career Henan Chemical Co
Product
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione 438190-29-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

438190-29-5, (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedioneRelated Search:

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  • (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
  • TCS PIM-1 4a
  • SMI-4a
  • (Z)-5-(3-(trifluoroMethyl)benzylidene)thiazolidine-2,4-dione
  • 2,4-Thiazolidinedione, 5-[[3-(trifluoromethyl)phenyl]methylene]-, (5Z)-
  • TCS PIM-1 4a, >=98%
  • (5E)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione
  • (Z)-SMI-4a
  • TCS PIM-1 4a (SMI-4a)
  • SMI-4A; SMI4A
  • CS-2669
  • CS-1477
  • SMI 4a - Pim inhibitor 4a
  • SMI-4a, >97%
  • SMI-4A; SMI4A; SMI 4A; TCS PIM-1 4A.
  • SMI-4A; SMI4A;(Z)-SMI4A; (Z)-SMI 4A
  • 5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione USP/EP/BP
  • SMI-4a TCS PIM-1 4a
  • SMI-4a（b）
  • 438190-29-5
  • Inhibitors
  • JAK
  • STAT
  • Inhibitor