ChemicalBook > CAS DataBase List > N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

Product Name
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
CAS No.
55778-02-4
Chemical Name
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Synonyms
WZ 811;CS-567;DK7350;WZ-811; WZ811;WZ 811, >=98%;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
CBNumber
CB62518930
Molecular Formula
C18H18N4
Formula Weight
290.36
MOL File
55778-02-4.mol
More
Less

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Property

Melting point:
192-194℃ (methanol )
Boiling point:
493.2±35.0 °C(Predicted)
Density 
1.229±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: ≥7mg/mL
form 
powder
pka
6.55±0.10(Predicted)
color 
white to tan
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2933.39.6190
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0088
Product name
WZ 811
Purity
≥98% (HPLC)
Packaging
5mg
Price
$104
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0088
Product name
WZ 811
Purity
≥98% (HPLC)
Packaging
25mg
Price
$397
Updated
2023/01/07
TCI Chemical
Product number
W0017
Product name
WZ 811
Packaging
25MG
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
W0017
Product name
WZ 811
Packaging
100MG
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
13639
Product name
WZ 811
Purity
≥95%
Packaging
1mg
Price
$19
Updated
2024/03/01
More
Less

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties,Usage,Production

Description

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.

Uses

N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.

References

[1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-(817)863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
EA Consulting
Tel
--
Fax
--
Email
contact@ea-synthconsulting.com
Country
United States
ProdList
21
Advantage
0
More
Less

View Lastest Price from N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine manufacturers

Career Henan Chemical Co
Product
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine 55778-02-4
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

55778-02-4, N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamineRelated Search:


  • N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
  • WZ 811
  • N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE
  • N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine
  • N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
  • 1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-
  • N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811
  • WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine
  • WZ 811, >=98%
  • WZ-811; WZ811
  • CS-567
  • N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
  • N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine USP/EP/BP
  • DK7350
  • Inhibitor,inhibit,WZ811,WZ 811,CXCR,WZ-811,CXC chemokine receptors
  • N,N'-(1,4-Phenylenebis(methylene))bis(pyridin-2-amine)
  • 55778-02-4
  • Inhibitors