ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

Product Name: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
CAS No.: 155377-19-8
Chemical Name: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
Synonyms: ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;BUTTPARK 29\06-81;Ethyl 3-(trifluoromethyl)pyrazole-4-c;ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-;ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate97%;Ethyl3-(Trifluoromethyl)pyrazole-4-carboxylate>Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate 97%;Ethyl 3-(trifluoromethyl)-2H-pyrazole-4-carboxylate;Ethyl3-trifluoromethyl-1H-pyrazole-4-carboxylate,97%
CBNumber: CB6254184
Molecular Formula: C7H7F3N2O2
Formula Weight: 208.14
MOL File: 155377-19-8.mol

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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Property

Melting point:: 145 °C
Boiling point:: 301.3±42.0 °C(Predicted)
Density: 1.397±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 8.26±0.50(Predicted)
color: White to Light yellow
CAS DataBase Reference: 155377-19-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681873
Product name: Ethyl 3- (trifluoromethyl)-1H-pyrazole-4-carboxylate
Purity: 97%
Packaging: 5g
Price: $123
Updated: 2022/05/15

TCI Chemical

Product number: E1024
Product name: Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: E1024
Product name: Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $205
Updated: 2025/07/31

TRC

Product number: E931250
Product name: Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate
Packaging: 10g
Price: $330
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-3-34
Product name: Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate
Purity: 97%
Packaging: 25g
Price: $456
Updated: 2021/12/16

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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White to tan powder

Uses

Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate (cas# 155377-19-8) is a compound useful in organic synthesis.

Synthesis

571-55-1

155377-19-8

The general procedure for the synthesis of ethyl 3-trifluoromethylpyrazole-4-carboxylate from ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate was as follows: hydrazine hydrate (10 g, 0.199 mol) was dissolved in ethanol (400 mL) and the solution was cooled to 0 °C. A solution of ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (47.03 g, 0.19 mol) in ethanol (200 mL) was added dropwise to this cooled solution over 90 min. The reaction mixture was kept at 0 °C. Subsequently, the reaction solution was slowly warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, the mixture was concentrated to dryness. The resulting residue was dispersed in boiling cyclohexane (200 mL) and then cooled to room temperature. The precipitate was collected by filtration and washed with cyclohexane. Finally, the product was dried under vacuum at 75 °C to afford ethyl 3-trifluoromethylpyrazole-4-carboxylate (compound 3f) as a yellow powder (38.67 g, 95% yield). The melting point of the product was 145 °C. 1H NMR (CDCl3) data: δ 1.40 (t, 3H, J = 7.0 Hz), 4.39 (q, 2H, J = 7.0 Hz), 8.26 (s, 1H), 13.2 (s (br), 1H). 13C NMR (CDCl3) data: δ 14.0, 61.2, 113.4, 121.0 ( q, J = 268 Hz), 135.3, 142.0 (q, J = 38 Hz), 160.8. High-resolution mass spectrometry (HRMS) analysis: calculated value of 207.0381 for C7H7F3N2O2-H; measured value of 207.0377.

References

[1] Tetrahedron, 2011, vol. 67, # 44, p. 8451 - 8457
[2] Patent: WO2016/81918, 2016, A1. Location in patent: Paragraph 00279
[3] Patent: WO2016/151403, 2016, A1. Location in patent: Paragraph 00521
[4] Patent: WO2017/205684, 2017, A1. Location in patent: Paragraph 00692; 00693
[5] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 47 - 56

ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Acetic anhydride Triethyl orthoformate Hydrazine dihydrochloride

Preparation Products

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ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate 155377-19-8
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 155377-19-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

155377-19-8, ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATERelated Search:

BUTTPARK 29\06-81

ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

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155377-19-8

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