ChemicalBook > CAS DataBase List > 4-Methyl Erlotinib Hydrochloride

4-Methyl Erlotinib Hydrochloride

Product Name: 4-Methyl Erlotinib Hydrochloride
CAS No.: 1346601-52-2
Chemical Name: 4-Methyl Erlotinib Hydrochloride
Synonyms: OSI-597;Erlotinib-9;4-methyl Erlotinib;Erlotinib iMpurity G;Erlotinib impurities406;Erlotinib 4-Methyl Analog;4-Methyl Erlotinib Hydrochloride;Azilsartan medoxomil impurity248;Erlotinib Hydrochloride iMpurity 8;N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
CBNumber: CB62544810
Molecular Formula: C23H25N3O4
Formula Weight: 407.46
MOL File: 1346601-52-2.mol

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4-Methyl Erlotinib Hydrochloride Property

Melting point:: 224-228°C (dec.)
Boiling point:: 567.5±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO, Methanol (Slightly)
pka: 5.33±0.30(Predicted)
form: Solid
color: Pale Pink to Pale Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9001510
Product name: 4-methyl Erlotinib
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 9001510
Product name: 4-methyl Erlotinib
Purity: ≥95%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 9001510
Product name: 4-methyl Erlotinib
Purity: ≥95%
Packaging: 10mg
Price: $632
Updated: 2024/03/01

TRC

Product number: M304630
Product name: 4-MethylErlotinibHydrochloride
Packaging: 5mg
Price: $245
Updated: 2021/12/16

TRC

Product number: M304630
Product name: 4-MethylErlotinibHydrochloride
Packaging: 50mg
Price: $1940
Updated: 2021/12/16

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4-Methyl Erlotinib Hydrochloride Chemical Properties,Usage,Production

Uses

Erlotinib (E625000) derivative as internal standard for HPLC.

Biological Activity

4-methyl erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (egfr) [1].the epidermal growth factor receptor (egfr) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].erlotinib inhibits egfr-associated kinase activity by binding to the egf-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].

References

[1] stamos, j. ,sliwkowski, m.x. and eigenbrot, c. structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. the journal of biological chemisty 277(48), 46265-46272 (2002).
[2] ciardiello f, tortora g. a novel approach in the treatment of cancer: targeting the epidermal growth factor receptor[j]. clinical cancer research, 2001, 7(10): 2958-2970.
[3] shepherd f a, rodrigues pereira j, ciuleanu t, et al. erlotinib in previously treated non–small-cell lung cancer[j]. new england journal of medicine, 2005, 353(2): 123-132.

4-Methyl Erlotinib Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1346601-52-2, 4-Methyl Erlotinib HydrochlorideRelated Search:

Erlotinib iMpurity 2 Erlotinib iMpurity 3 2,3,5-Trimethylpyridine-1-Oxide Ethyl 3,4-dihydroxybenzoate 3-Ethynylaniline 6,7-bis(2-methoxyethoxy)-N-phenylquinazolin-4-amine Erlotinib iMpurity 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline Erlotinib hydrochloride Desmethyl Erlotinib Acetate OSI-420 Erlotinib Erlotinib Impurity 20 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Erlotinib D6 HCl Didesmethyl Erlotinib Hydrochloride Salt

N-[(3-Ethynyl-4-Methyl)phenyl]-6,7-bis(2-Methoxyethoxy)-4-quinazolinaMine Hydrochloride

OSI-597

Erlotinib iMpurity G

N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride

4-Methyl Erlotinib Hydrochloride

N-(3-ETHYNYL-4-METHYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HCL

4-methyl Erlotinib

Erlotinib 4-Methyl Analog

N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

Erlotinib-9

Erlotinib Hydrochloride iMpurity 8

N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quizolin-4-aminehydrochloride

Erlotinib impurity 15/N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride

4-Quinazolinamine, N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-

N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

Azilsartan medoxomil impurity248

Erlotinib impurities406

Erlotinib impurity GQ: What is Erlotinib impurity G Q: What is the CAS Number of Erlotinib impurity G Q: What is the storage condition of Erlotinib impurity G

1346601-52-2

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