ChemicalBook > CAS DataBase List > 4-Methyl Erlotinib Hydrochloride
4-Methyl Erlotinib Hydrochloride
- Product Name
- 4-Methyl Erlotinib Hydrochloride
- CAS No.
- 1346601-52-2
- Chemical Name
- 4-Methyl Erlotinib Hydrochloride
- Synonyms
- OSI-597;Erlotinib-9;4-methyl Erlotinib;Erlotinib iMpurity G;Erlotinib impurities406;Erlotinib 4-Methyl Analog;4-Methyl Erlotinib Hydrochloride;Azilsartan medoxomil impurity248;Erlotinib Hydrochloride iMpurity 8;N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
- CBNumber
- CB62544810
- Molecular Formula
- C23H25N3O4
- Formula Weight
- 407.46
- MOL File
- 1346601-52-2.mol
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4-Methyl Erlotinib Hydrochloride Property
- Melting point:
- 224-228°C (dec.)
- Boiling point:
- 567.5±50.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO, Methanol (Slightly)
- pka
- 5.33±0.30(Predicted)
- form
- Solid
- color
- Pale Pink to Pale Brown
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 9001510
- Product name
- 4-methyl Erlotinib
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 9001510
- Product name
- 4-methyl Erlotinib
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 9001510
- Product name
- 4-methyl Erlotinib
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
TRC
- Product number
- M304630
- Product name
- 4-MethylErlotinibHydrochloride
- Packaging
- 5mg
- Price
- $245
- Updated
- 2021/12/16
TRC
- Product number
- M304630
- Product name
- 4-MethylErlotinibHydrochloride
- Packaging
- 50mg
- Price
- $1940
- Updated
- 2021/12/16
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4-Methyl Erlotinib Hydrochloride Chemical Properties,Usage,Production
Uses
Erlotinib (E625000) derivative as internal standard for HPLC.
Biological Activity
4-methyl erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (egfr) [1].the epidermal growth factor receptor (egfr) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].erlotinib inhibits egfr-associated kinase activity by binding to the egf-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].
References
[1] stamos, j. ,sliwkowski, m.x. and eigenbrot, c. structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. the journal of biological chemisty 277(48), 46265-46272 (2002).
[2] ciardiello f, tortora g. a novel approach in the treatment of cancer: targeting the epidermal growth factor receptor[j]. clinical cancer research, 2001, 7(10): 2958-2970.
[3] shepherd f a, rodrigues pereira j, ciuleanu t, et al. erlotinib in previously treated non–small-cell lung cancer[j]. new england journal of medicine, 2005, 353(2): 123-132.
4-Methyl Erlotinib Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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1346601-52-2, 4-Methyl Erlotinib HydrochlorideRelated Search:
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