Azelastine
- Product Name
- Azelastine
- CAS No.
- 58581-89-8
- Chemical Name
- Azelastine
- Synonyms
- -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP
- CBNumber
- CB6256007
- Molecular Formula
- C22H24ClN3O
- Formula Weight
- 381.9
- MOL File
- 58581-89-8.mol
Azelastine Property
- Melting point:
- 111 - 115°C
- Boiling point:
- 533.9±60.0 °C(Predicted)
- Density
- 1.1505 (rough estimate)
- refractive index
- 1.5790 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- pKa 9.82(H2O t=25 I=0.025) (Uncertain)
- form
- Solid
- color
- White to Off-White
- BCS Class
- 1?
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- CAS DataBase Reference
- 58581-89-8(CAS DataBase Reference)
Safety
- Hazardous Substances Data
- 58581-89-8(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A767410
- Product name
- Azelastine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- A767410
- Product name
- Azelastine
- Packaging
- 2.5g
- Price
- $610
- Updated
- 2021/12/16
- Product number
- FC130471
- Product name
- 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FC130471
- Product name
- 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 099439
- Product name
- 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
Azelastine Chemical Properties,Usage,Production
Description
Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .
Uses
anesthetic, anticonvulsant
Definition
ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.
brand name
Astelin (Medpointe); Optivar (Medpointe).
Clinical Use
Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.
Safety Profile
Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl- .
Azelastine Preparation Products And Raw materials
Raw materials
Preparation Products
Azelastine Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
- 6446
- Advantage
- 42
- Tel
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- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- sales@gs-chem.com
- Country
- United Kingdom
- ProdList
- 6098
- Advantage
- 47
- Tel
- --
- Fax
- --
- sales@seqchem.com
- Country
- United Kingdom
- ProdList
- 3113
- Advantage
- 69
View Lastest Price from Azelastine manufacturers
- Product
- Azelastine 58581-89-8
- Price
- US $0.00/g/Bag
- Min. Order
- 10g
- Purity
- 98%min
- Supply Ability
- 120kg/month
- Release date
- 2021-06-05
- Product
- Azelastine 58581-89-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 90%+
- Supply Ability
- 10g
- Release date
- 2021-09-04
- Product
- 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 58581-89-8
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 20kg
- Release date
- 2018-07-27