Azelastine

Product Name: Azelastine
CAS No.: 58581-89-8
Chemical Name: Azelastine
Synonyms: -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP
CBNumber: CB6256007
Molecular Formula: C22H24ClN3O
Formula Weight: 381.9
MOL File: 58581-89-8.mol

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Azelastine Property

Melting point:: 111 - 115°C
Boiling point:: 533.9±60.0 °C(Predicted)
Density: 1.1505 (rough estimate)
refractive index: 1.5790 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka: pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form: Solid
color: White to Off-White
BCS Class: 1?
Stability:: Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS DataBase Reference: 58581-89-8(CAS DataBase Reference)

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Safety

Hazardous Substances Data: 58581-89-8(Hazardous Substances Data)
Toxicity: LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A767410
Product name: Azelastine
Packaging: 2.5g
Price: $610
Updated: 2021/12/16

TRC

Product number: A767410
Product name: Azelastine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC130471
Product name: 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC130471
Product name: 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging: 100mg
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: C809
Product name: Azelastine
Packaging: 1g
Price: $617
Updated: 2021/12/16

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Azelastine Chemical Properties,Usage,Production

Description

Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

brand name

Astelin (Medpointe); Optivar (Medpointe).

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl^- .

Azelastine Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane Acetophenone

Preparation Products

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Azelastine Suppliers

China 119 Europe 3 India 8 United Kingdom 5 United States 25 Global 160

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19881
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Alfa Chemistry

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Country: United States
ProdList: 6814
Advantage: 0

3B Scientific Corporation

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Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

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Country: United States
ProdList: 6516
Advantage: 60

United States Biological

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Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

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Country: United States
ProdList: 6618
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Matrix Scientific

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Labseeker Inc

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Santa Cruz Biotechnology, Inc.

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Beta Pharma, Inc.

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Country: United States
ProdList: 6226
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Waterstone Technology, LLC

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Country: United States
ProdList: 6786
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2A PharmaChem USA

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3B Scientific Corporation

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AK Scientific, Inc.

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APAC Pharmaceutical, LLC

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SynFine Research

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ChemPacific Corporation

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BOSCHE SCIENTIFIC, LLC

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Country: United States
ProdList: 6477
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View Lastest Price from Azelastine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Azelastine 58581-89-8
Price: US $0.00/g/Bag
Min. Order: 10g
Purity: 98%min
Supply Ability: 120kg/month
Release date: 2021-06-05

Guangzhou PI PI BIOTECH INC

Product: Azelastine 58581-89-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-04

Career Henan Chemical Co

Product: 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 58581-89-8
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 20kg
Release date: 2018-07-27

58581-89-8, AzelastineRelated Search:

METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Methylparaben Methyl acrylate 2,6-DIMETHYLNAPHTHALENE 2-Methylnaphthalene Bensulfuron methyl Thiophanate-methyl 1-AdaMantanethylaMine Kresoxim-methyl DBU Chlorodimethylphenylsilane Triphenylphosphine Methyl Phenylacetone Sibutramine hydrochloride Parathion-methyl AZELASTINE HCL,AZELASTINE HYDROCHLORIDE

1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin

4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon

4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride

4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one

4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one

Azelastinum [INN-Latin]

KBio3_002992

SPBio_000657

Spectrum2_000649

Spectrum3_001984

4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone

-4-yl)-

AZELASTINE

1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one

CAS 790307-93-0

Azeptin：Rhino1ast

2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one

4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one

4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone

Azelastine & Azelastine Hydrochloride

Azelastine base

4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one

4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone

4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one

4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2

Azelastine USP/EP/BP

Phenylpyruvic Acid Impurity 7

Azelastine, 10 mM in DMSO

58581-89-8

53408-27-6

C22H26ClN3O

TELAZOL

API