ChemicalBook > CAS DataBase List > BAF-312(SiponiMod)

BAF-312(SiponiMod)

Product Name: BAF-312(SiponiMod)
CAS No.: 1230487-00-9
Chemical Name: BAF-312(SiponiMod)
Synonyms: SiponiMod;Siponimod (BAF-312);SIPONIMOD; SIPONIMOD [INN]; BAF-312; BAF 312;(E)-1-(4-(1-(4-cyclohexyl-3-(trifluoromethyl)benzyloxyimino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid;CS-1753;Sinimod;Siponimod D11;D11-Siponimod;Siponimod [INN];BAF-312(SiponiMod)
CBNumber: CB62725945
Molecular Formula: C29H35F3N2O3
Formula Weight: 516.59
MOL File: 1230487-00-9.mol

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BAF-312(SiponiMod) Property

Melting point:: 154 - 157°C
Boiling point:: 602.0±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.69±0.20(Predicted)
form: Solid
color: White to Off-White
InChIKey: KIHYPELVXPAIDH-HNSNBQBZSA-N
SMILES: N1(CC2=CC=C(/C(=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)/C)C=C2CC)CC(C(O)=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3830
Product name: BAF312
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3830
Product name: BAF312
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $328
Updated: 2025/07/31

Cayman Chemical

Product number: 22057
Product name: Siponimod
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22057
Product name: Siponimod
Purity: ≥98%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 22057
Product name: Siponimod
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

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BAF-312(SiponiMod) Chemical Properties,Usage,Production

Description

S1p signaling is important for immune, cardiovascular, and CNS function.Like its FDA approved predecessor fingolimod, siponimod is an oral S1p signaling modulator.While fin- golimod binds four out of five known S1p receptors, siponimod is selective for receptor sub- types 1 and 5. This selectivity may allow for an improved adverse event profile.

Uses

Siponimod is a functional sphingosine -1 phosphate (SIP) antagonist used in the treatment of multiple sclerosis and other central nervous system-related diseases in human subjects. .

Side effects

Siponimod,2 mg/day, was studied in a Phase I placebo-controlled trial in patients with secondary progressive Ms.206The primary endpoint was time to 3 months confirmed dis- ability progression. There were substantive side effects from the drug，mainly increased liver transaminase concentrations,bradycardia, and bradyarrhythmia at treatment initiation.With subsequent siponimod administration，there was an increased incidence of macular edema, hypertension,varicella zoster reactivation, and convulsions compared to placebo. By grad- ually escalating the initial dose of siponimod, cardiac first-dose effects were reduced.While the results of this trial are encouraging,long- term safety issues may be a greater concern5or since persons with secondary progressive MS as a group are older,with a higher incidence of comorbidities that could preclude use of siponimod.

Synthesis

Synthesis of BAF-312(SiponiMod)

in vivo

Siponimod (1 g/kg; i.v.; single dose) shows low to moderate in monkey, but high in rat in metabolism studies with liver microsomes. The absolute bioavailability is 50 and 71% in the rat and monkey, respectively, indicating no major presystemic first pass metabolism^[1].
Siponimod (0.3, 3 mg/kg; p.o.; once daily; 23 d) suppresses experimental autoimmune encephalomyelitis (EAE) in rats by internalizing S1P1 receptors^[2].
Parmacokinetics of Siponimod in rats and monkey^[1]

/td>	CL (L/h/kg)	V_ss (L/kg)	T_1/2 (h)	F (%)
Rat	0.36	2.15	6	50
Monkey	0.098/td>	2.12	19	71

Animal Model:	Experimental autoimmune encephalomyelitis (EAE) model in Lewis rats (200-250 g)^[2]
Dosage:	0.03, 0.3, 3 mg/kg
Administration:	Oral gavage; once daily; 23 days
Result:	Decreased peripheral lymphocyte counts by 88% at the T_{max_{of 8 h postadministration.}}

target

S1P1 receptors

IC 50

S1PR1: 0.39 nM (EC₅₀); S1PR5: 0.98 nM (EC₅₀); S1PR4: 750 nM (EC₅₀); S1PR3: >1000 nM (EC₅₀); S1PR2: >10000 nM (EC₅₀)

References

[1] gergely p1, nuesslein-hildesheim b, guerini d, brinkmann v, traebert m, bruns c, pan s, gray ns, hinterding k, cooke ng, groenewegen a, vitaliti a, sing t, luttringer o, yang j, gardin a, wang n, crumb wj jr, saltzman m, rosenberg m, wallström e. the selective sphingosine 1-phosphate receptor modulator baf312 redirects lymphocyte distribution and has species-specific effects on heart rate. br j pharmacol. 2012 nov;167(5):1035-47.
[2] pan s1, gray ns1, gao w1, mi y1, fan y1, wang x1, tuntland t1, che j1, lefebvre s1, chen y1, chu a1, hinterding k2, gardin a2, end p2, heining p2, bruns c2, cooke ng2, nuesslein-hildesheim b2 .discovery of baf312 (siponimod), a potent and selective s1p receptor modulator. acs med chem lett. 2013 jan 4;4(3):333-7.

BAF-312(SiponiMod) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BAF-312(SiponiMod) manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: BAF-312(SiponiMod) 1230487-00-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-08-07

Wuhan Nutra Biotechnology Co.,Ltd

Product: SiponiMod; BAF-312 1230487-00-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10kgs
Release date: 2021-05-23

Hangzhou ICH Biofarm Co., Ltd

Product: BAF-312(SiponiMod) 1230487-00-9
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-12

1230487-00-9, BAF-312(SiponiMod)Related Search:

Tapinarof Pidotimod Semapimod Iguratimod CIVENTICHEM CV-4057 tasquinimod Tiprotimod APILIMOD Ozanimod Fingolimod hydrochloride Thiazovivin SB 431542 ABT 737 Luminespib ABT 263 Vatalanib Dihydrochloride

BAF-312(SiponiMod)

SiponiMod

3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-

1-(4-[1-[(E)-4-Cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl-benzyl)-azetidine-3-carboxylic acid

(E)-1-(4-(1-(4-cyclohexyl-3-(trifluoromethyl)benzyloxyimino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid

BAF312 (Siponimod) 1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid

Siponimod (BAF-312)

Siponimod [INN]

SIPONIMOD; SIPONIMOD [INN]; BAF-312; BAF 312

CS-1753

BAF-312(SiponiMod) USP/EP/BP

Siponimod D11

1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid

Formyl sitagliptin d4

Sinimod

Siponimod, 10 mM in DMSO

D11-Siponimod

1230487-00-9

C29H35F3N2O3

API

Inhibitors