SM 7368
- Product Name
- SM 7368
- CAS No.
- 380623-76-7
- Chemical Name
- SM 7368
- Synonyms
- SM-7368;SM 7368;SM-7368, 10 mM in DMSO;SM 7368, NF-kappaB inhibitor;NFκB Activation Inhibitor III;NF-oB Activation Inhibitor III;3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide;3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide;Benzamide, 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-;3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
- CBNumber
- CB62750666
- Molecular Formula
- C10H5ClN4O5S
- Formula Weight
- 328.69
- MOL File
- 380623-76-7.mol
SM 7368 Property
- Density
- 1.761±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL (clear solution)
- form
- powder
- pka
- 5.18±0.50(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 481411
- Product name
- NF-κB Activation Inhibitor III
- Packaging
- 5mg
- Price
- $176
- Updated
- 2025/07/31
- Product number
- 19083
- Product name
- NF-κB Activation Inhibitor III
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 19083
- Product name
- NF-κB Activation Inhibitor III
- Purity
- ≥99%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- SML0454
- Product name
- SM-7368
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $504
- Updated
- 2022/05/15
- Product number
- N392518
- Product name
- NFkappaBActivationInhibitorIII
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
SM 7368 Chemical Properties,Usage,Production
Uses
NFkappaB Activation Inhibitor III is a TNF-α-stimulated NF kappa B activation inhibitor.
Biological Activity
nf-κb activation inhibitor iii is a nf-κb inhibitor.nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) is a protein complex controling transcription of dna, cytokine production as well as cell survival. nf-κb is found in nearly all animal cell types and is involved in cellular responses to stimuli such as cytokines, stress, free radicals, heavy metals, and bacterial or viral antigens.
in vitro
previous study found that nf-κb activation inhibitor iii could inhibite tnf-a-induced mmp-9 upregulation in concentration-dependently and showed maximal activity at 10 μm. nf-κb activation inhibitor iii also inhibited tnf-a-induced mmp-9 mrna transcript accumulation and protein expression. it was also found that nf-κb activation inhibitor iii strongly inhibited tnf-a-induced nf-jb activity but not ap-1 activity. in addition, nf-κb activation inhibitor iii was able to strongly inhibit the tnf-a-induced invasion of ht1080 human fibrosarcoma cell line. these findings demonstrated that nf-κb activation inhibitor iii was a synthetic compound inhibiting tnf-a-induced mmp-9 expression, and therefore nf-κb activation inhibitor iii would be useful for the development of chemotherapy targeting tnf-a-mediated tumor invasion and metastasis [1]. nf-κb activation inhibitor iii was used to disrupt nf-κb signaling to evaluate the role of syndecans in mediating extracellular matrix integrity [2].
IC 50
NF-κB; MMP-9; p38 MAP kinase
References
[1] h. y. lee, k. s. park, m. k. kim, et al. a small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. biochemical and biophysical research communications 336(2), 716-722 (2005).
[2] h. yang, h. liu, x. li, et al. tnf-α and tgf-β1 regulate syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and nf-κb pathways. connect.tissue res. 56(4), 281-287 (2015).
SM 7368 Preparation Products And Raw materials
Raw materials
Preparation Products
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