SM 7368

Product Name: SM 7368
CAS No.: 380623-76-7
Chemical Name: SM 7368
Synonyms: SM-7368;SM 7368;SM 7368, NF-kappaB inhibitor;NFκB Activation Inhibitor III;3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide;3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide;Benzamide, 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-;NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem;Matrix,Nuclear factor-kappaB,TNF-α,MMP-9,Inhibitor,SM-7368,p38 MAPK,Nuclear factor-κB,SM 7368,MAPK,NF-κB,SM7368,MMP,Invasion,inhibit,Matrix metalloproteinases
CBNumber: CB62750666
Molecular Formula: C10H5ClN4O5S
Formula Weight: 328.69
MOL File: 380623-76-7.mol

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SM 7368 Property

Density: 1.761±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
pka: 5.18±0.50(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 481411
Product name: NF-κB Activation Inhibitor III
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 19083
Product name: NF-κB Activation Inhibitor III
Purity: ≥99%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 19083
Product name: NF-κB Activation Inhibitor III
Purity: ≥99%
Packaging: 25mg
Price: $374
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0454
Product name: SM-7368
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $504
Updated: 2022/05/15

TRC

Product number: N392518
Product name: NFkappaBActivationInhibitorIII
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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SM 7368 Chemical Properties,Usage,Production

Uses

NFkappaB Activation Inhibitor III is a TNF-α-stimulated NF kappa B activation inhibitor.

Biological Activity

nf-κb activation inhibitor iii is a nf-κb inhibitor.nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) is a protein complex controling transcription of dna, cytokine production as well as cell survival. nf-κb is found in nearly all animal cell types and is involved in cellular responses to stimuli such as cytokines, stress, free radicals, heavy metals, and bacterial or viral antigens.

in vitro

previous study found that nf-κb activation inhibitor iii could inhibite tnf-a-induced mmp-9 upregulation in concentration-dependently and showed maximal activity at 10 μm. nf-κb activation inhibitor iii also inhibited tnf-a-induced mmp-9 mrna transcript accumulation and protein expression. it was also found that nf-κb activation inhibitor iii strongly inhibited tnf-a-induced nf-jb activity but not ap-1 activity. in addition, nf-κb activation inhibitor iii was able to strongly inhibit the tnf-a-induced invasion of ht1080 human fibrosarcoma cell line. these findings demonstrated that nf-κb activation inhibitor iii was a synthetic compound inhibiting tnf-a-induced mmp-9 expression, and therefore nf-κb activation inhibitor iii would be useful for the development of chemotherapy targeting tnf-a-mediated tumor invasion and metastasis [1]. nf-κb activation inhibitor iii was used to disrupt nf-κb signaling to evaluate the role of syndecans in mediating extracellular matrix integrity [2].

References

[1] h. y. lee, k. s. park, m. k. kim, et al. a small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. biochemical and biophysical research communications 336(2), 716-722 (2005).
[2] h. yang, h. liu, x. li, et al. tnf-α and tgf-β1 regulate syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and nf-κb pathways. connect.tissue res. 56(4), 281-287 (2015).

SM 7368 Preparation Products And Raw materials

Raw materials

Preparation Products

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SM 7368 Suppliers

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380623-76-7, SM 7368Related Search:

6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol SMI-4a N-(4-BroMophenyl)-3,5-diMethyl-1-piperidinepropanaMide Hydrochloride 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol hydrochloride SM1-71 (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone SMI-16a SM-276001

3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide

SM 7368

SM-7368

NFκB Activation Inhibitor III

NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem

3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide

Matrix,Nuclear factor-kappaB,TNF-α,MMP-9,Inhibitor,SM-7368,p38 MAPK,Nuclear factor-κB,SM 7368,MAPK,NF-κB,SM7368,MMP,Invasion,inhibit,Matrix metalloproteinases

Benzamide, 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-

SM 7368, NF-kappaB inhibitor

380623-76-7

C10H5ClN4O5S