DBCO-Acid
- Product Name
- DBCO-Acid
- CAS No.
- 1353016-70-2
- Chemical Name
- DBCO-Acid
- Synonyms
- Dibenzocyclooctyne-acid;DBCO-Acid;DBCO-COOH;DBCO acid 1;DBCO-C4-COOH;CAS_1353016-70-2;DBCO-(CH2)2-COOH;Azadibenzocyclooctyne acid;Diphenylcyclooctyne carboxylic acid;[DBCO-COOH] Dibenzocyclooctynes acid
- CBNumber
- CB62985653
- Molecular Formula
- C19H15NO3
- Formula Weight
- 305.33
- MOL File
- 1353016-70-2.mol
DBCO-Acid Property
- Melting point:
- 118-125 °C
- Boiling point:
- 622.0±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in dimethyl sulfoxide and dimethyl formamide.
- pka
- 4.47±0.17(Predicted)
- form
- Solid
- color
- Off-white to Gray
- InChI
- InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
- InChIKey
- NDLOVDOICXITOK-UHFFFAOYSA-N
- SMILES
- O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- J64549
- Product name
- Azadibenzocyclooctyne acid
- Packaging
- 25mg
- Price
- $166
- Updated
- 2023/06/20
- Product number
- J64549
- Product name
- Azadibenzocyclooctyne acid
- Packaging
- 100mg
- Price
- $465
- Updated
- 2023/06/20
- Product number
- D194970
- Product name
- DBCO-Acid
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 35054
- Product name
- DBCOacid,99%(HPLC)
- Purity
- 99%(HPLC)
- Packaging
- 5MG
- Price
- $44.8
- Updated
- 2021/12/16
- Product number
- 35054
- Product name
- DBCOacid,≥99%(HPLC)
- Purity
- ≥99%(HPLC)
- Packaging
- 25MG
- Price
- $99.01
- Updated
- 2021/12/16
DBCO-Acid Chemical Properties,Usage,Production
Description
DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.
Application
DBCO-acid (11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid) is a cleavable antibody-drug conjugate (ADC) linker used in the synthesis of ADC linkers DBCO-NHS ester (HY-115524 and HY-115545) and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is also a click chemistry reagent that contains a DBCO group in its structure and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.
General Description
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
DBCO-Acid Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-Acid Suppliers
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View Lastest Price from DBCO-Acid manufacturers
- Product
- DBCO-acid 1353016-70-2
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >99.00%
- Supply Ability
- 10g
- Release date
- 2024-03-20