ChemicalBook > CAS DataBase List > Lipoamido-PEG4-acid

Lipoamido-PEG4-acid

Product Name
Lipoamido-PEG4-acid
CAS No.
1314378-10-3
Chemical Name
Lipoamido-PEG4-acid
Synonyms
LA-PEG4-COOH;Lipoamido-PEG-acid;Lipoamido-PEG4-acid;LIPOAMIDO-PEG4-COOH;Lipoamido-PEG4-CH2CH2COOH;4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo-;Lipoamido-PEG4-CH2CH2COOH/4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo
CBNumber
CB63062519
Molecular Formula
C19H35NO7S2
Formula Weight
453.61
MOL File
1314378-10-3.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-22164
Product name
Lipoamido-PEG4-acid
Purity
95%
Packaging
100mg
Price
$320
Updated
2021/12/16
BroadPharm
Product number
BP-22164
Product name
Lipoamido-PEG4-acid
Purity
95%
Packaging
250mg
Price
$530
Updated
2021/12/16
Apolloscientific
Product number
BIPG1465
Product name
Lipoamido-PEG4-acid
Packaging
100mg
Price
$623
Updated
2021/12/16
BroadPharm
Product number
BP-22164
Product name
Lipoamido-PEG4-acid
Purity
95%
Packaging
500mg
Price
$780
Updated
2021/12/16
Acrotein
Product number
B-1556
Product name
Lipoamido-PEG4-CH2CH2COOH
Purity
97%
Packaging
0.5g
Price
$660
Updated
2021/12/16
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Lipoamido-PEG4-acid Chemical Properties,Usage,Production

Description

Lipoamido-PEG4-acid contains a lipoic acid group and a terminal carboxylic acid. Lipoic acid contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

Lipoamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Lipoamido-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Lipoamido-PEG4-acid Suppliers

Hunan HuaTeng Pharmaceutical Co., Ltd.,
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TargetMol Chemicals Inc.
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1314378-10-3, Lipoamido-PEG4-acidRelated Search:


  • Lipoamido-PEG4-acid
  • LA-PEG4-COOH
  • LIPOAMIDO-PEG4-COOH
  • Lipoamido-PEG4-CH2CH2COOH
  • 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo-
  • Lipoamido-PEG-acid
  • Lipoamido-PEG4-CH2CH2COOH/4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo
  • 1314378-10-3
  • C19H35NO7S2
  • peg