Fibronectin

ChemicalBook > CAS DataBase List > Fibronectin

Product Name: Fibronectin
CAS No.: 86088-83-7
Chemical Name: Fibronectin
Synonyms: FN;HFN;cig;FINC;HFFN;FIBRONECTIN;Fibronectins;fibronectin 1;FIBRONECTIN, RAT;Einecs 289-149-2
CBNumber: CB6306551
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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Fibronectin Property

storage temp.: -20°C
solubility: H₂O: 1 mg/mL at 37 °C Store reconstituted solution in working aliquots at -20°C or lower.
form: solution
color: White to off-white
Water Solubility: Miscible with water.

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Safety

Hazard Codes: B
WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F2518
Product name: Fibronectin human foreskin fibroblasts
Purity: lyophilized powder, suitable for cell culture
Packaging: 0.5mg
Price: $830
Updated: 2024/03/01

Sigma-Aldrich

Product number: F0895
Product name: Fibronectin human plasma
Purity: liquid, 0.1% (Solution), BioReagent, suitable for cell culture
Packaging: 1mg
Price: $272
Updated: 2024/03/01

Sigma-Aldrich

Product number: F0895
Product name: Fibronectin human plasma
Purity: liquid, 0.1% (Solution), BioReagent, suitable for cell culture
Packaging: 2mg
Price: $453
Updated: 2024/03/01

Sigma-Aldrich

Product number: F0895
Product name: Fibronectin human plasma
Purity: liquid, 0.1% (Solution), BioReagent, suitable for cell culture
Packaging: 5mg
Price: $928
Updated: 2024/03/01

Sigma-Aldrich

Product number: F0635
Product name: Fibronectin rat plasma
Purity: powder, BioReagent, suitable for cell culture
Packaging: 0.5mg
Price: $521
Updated: 2024/03/01

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Fibronectin Chemical Properties,Usage,Production

Description

Fibronectin (FN) is a glycoprotein whose size ranges from 230 to 270 kDa and usually exists as a dimer, covalently linked by a pair of disulfide bonds at the C-termini. Each monomer consists of three repeating units: 12 Type I, 2 Type II, and 15–17 Type III domains, which account for 90% of the FN sequence. Structural homologs of the Type I, II, and III domains exist in other biomolecules, suggesting that FN evolved through exon shuffling. Despite originating from a single gene, as many as 20 different human variants and 12 different rodent and cow variant FN isoforms have been identified, indicating alternative splicing mechanisms unique to species and tissue development. FN is subcategorized as either plasma FN (pFN), predominantly synthesized by liver hepatocytes, or cellular FN (cFN), which is produced by a wide variety of cells, including fibroblasts, chondrocytes, myocytes, and synovial cells. pFN circulates in the blood at a high concentration (approximately 300 μg/mL), while cFN is locally secreted[1].

Uses

Fibronectin solution from human fibroblasts is used for the following applications:

It is used in purification of human extracellular matrix (ECM)
Coating of tissue culture plates with extracellular matrix components
Used during cell culture (For xeno-free, feeder-free culture the cells were passaged in to human fibronectin along with other components)

Fibronectin from human plasma can be used with epithelial cells, mesenchymal cells, neuronal cells, fibroblasts, neural crest cells, and endothelial cells. It is recommended for use as a cell culture substratum at 1-5 μg/cm² or 0.5-50 μg/mL. The optimal concentration does depend on cell type as well as the application and research objectives.

Uses

fibronectin (hydrolyzed) is a humectant and moisturizing agent for skin creams and lotions.

Uses

fibronectin is a cosmetic ingredient described as a surface protective agent with a moisturizing and protective effect. Produced by many types of cells, fibronectin is a glycoprotein and an important component of the skin’s basal layer. Research suggests fibronectin plays a significant role in maintaining a healthy basal layer. Fibronectin’s function in the skin is to strengthen the attachments among collagen and elastin fibers, fibroblasts, and other cells in the dermis with connective tissues. Its presence may also be important to cell growth. There is some evidence that fibronectin may act as a cell regenerator by reversing abnormal cell formation and growth. It constitutes 1 to 3 percent of the total cellular protein of fibroblasts.

General Description

Native fibronectin purified from human plasma. Effective agent for promoting attachment of cells to commonly-used culture substrates.

Biochem/physiol Actions

Fibronectin is a high molecular mass extracellular matrix glycoprotein involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, cell migration/adhesion, and embryogenesis and development. It is used in vitro as a substrate to enhance adherence and proliferation of many cell types. It has the capacity to bind to macromolecules such as collagen, fibrin, glycosaminoglycans, and Clq, apart from some bacteria.

Purification Methods

This glycoprotein contains 5-12% of carbohydrate. It has been purified by glycine fractionation and DEAE-cellulose chromatography. This material is dissolved in 0.25M Tris-phosphate buffer pH 7.0, diluted to 20% and glycine added gradually till 2.1M when the temperature falls to below 15o. The precipitate contains mainly fibrinogen. The supernatant is discarded, and the precipitate is treated with an equal volume of H2O, cooled (to 0o) and precipitated by adding EtOH to 16% (v/v) at -4o. The precipitate contains some CI (Cold Insoluble) globulin, fibronectin and small quantities of other proteins. To remove these the precipitate is dissolved in 0.25M Tris-phosphate buffer (pH 7.0) ca 0.5% and purified by DEAE-cellulose chromatography after diluting the buffer to 0.05M buffer. [Morrison et al. J Am Chem Soc 70 3103 1948, Mosesson & Umfleet J Biol Chem 245 5728 1970, Mosesson & Amrani Blood 56 145 1980, Akiyama & Yamada Adv Enzymol 59 51 1987.]

References

[1] Dalton, Caleb J. and Christopher A. Lemmon. “Fibronectin: Molecular Structure, Fibrillar Structure, and Mechanochemical Signaling.”Cells 10 9 (2021): 2443.

Fibronectin Preparation Products And Raw materials

Raw materials

Preparation Products

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Fibronectin Suppliers

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View Lastest Price from Fibronectin manufacturers

ZhenYiBio Technology Inc

Product: FIBRONECTIN 86088-83-7
Price: US $230.00-190.00/KG
Min. Order: 1KG
Purity: 99%HPLC,USP Standard
Supply Ability: 800KGs
Release date: 2021-12-16

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Fibronectin, bovine 86088-83-7
Price: US $4.85/g
Min. Order: 100g
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-27

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: FIBRONECTIN 86088-83-7
Price: US $5.85/g
Min. Order: 100g
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-27

86088-83-7, FibronectinRelated Search:

COBALT(II) ACETYLACETONATE SALCOMINE Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Benzyl isocyanide Cupric acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Aluminum acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ethyl isocyanoacetate Ferric acetylacetonate PHENYLSELENOL N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) ANNEXIN V

Anti-Fibronectin 1, C-Terminal antibody produced in rabbit

fibronectin 1

FINC

Fibronectin solution from human fibroblasts

Fibronectin, bovine, stabilized soln.

HFN

FIBRONECTIN (MS PLASMA)

FIBRONECTIN, RAT

FIBRONECTIN, RAT PLASMA

FIBRONECTIN, SALMON

FIBRONECTIN, SALMON PLASMA

FIBRONECTIN, HUMAN

FIBRONECTIN (HUMAN CELLULAR)

FIBRONECTIN, HUMAN FIBROBLAST

FIBRONECTIN, HUMAN PLASMA

FIBRONECTIN, BOVINE

FIBRONECTIN, BOVINE PLASMA

FIBRONECTIN (BOV PLASMA)

FIBRONECTIN

Fibronectins

FIBRONECTIN FROM RAT PLASMA*ASEPTICALLY- FILLED CELL

FIBRONECTIN FROM HUMAN PLASMA

FIBRONECTIN FROM HUMAN PLASMA 0.1%*SOLUT ION CELL CU

FIBRONECTIN CELLULAR FROM HUMAN*FORESKIN FIBROBLAST

FIBRONECTIN FROM BOVINE PLASMA

FIBRONECTIN FROM BOVINE PLASMA*CELL CULT URE TESTED

cig

fibronectin from human foreskin fibroblasts

fibronectin from rat plasma

FIBRONECTIN SOLUTION, FROM BOVINE

Einecs 289-149-2

Fibronectin from human plasma,CIG, Cold insoluble globulin

Fibronectin from bovine plasma,CIG, Cold insoluble globulin

Fibronectin (huMan) lyophil. analytical grade, sterile

CELLULAR FIBRONECTIN, HUMAN

COLD INSOLUBLE GLOBULIN

HFFN

Nano Liposomal fibronectin

Nonative fibronectin

Fibronectin (pure)

Fibronectin human foreskin fibroblasts

Fibronectin solution human fibroblasts

Recombinant Human Fibronectin

Fibronectin, from Bovine Plasma, New Zealand Origin

Fibronectins Recombinant Human

Human FN Protein, His Tag

Fibronectin from bovine plasma solution, sterile-filtered, suitable for cell culture

lyophilized powder, BioReagent, suitable for cell culture

Recombinant Human Fibronectin from Oryza sativa,OsrhFN

Recombinant Human Fibronectin Protein

Fibronectin(FN)from human plasma

86088-83-7

Extracellular Matrix

Extracellular Matrix Peptides and Proteins

Cytoskeleton and Extracellular Matrix

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Cell Biology