ChemicalBook > CAS DataBase List > MK-4101

MK-4101

Product Name
MK-4101
CAS No.
935273-79-3
Chemical Name
MK-4101
Synonyms
MK-4101;MK4101;MK 4101;MK-4101;Apoptosis,inhibit,MK4101,Smoothened,MK-4101,MK 4101,Hedgehog,Inhibitor,Smo;5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole;1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-
CBNumber
CB63123144
Molecular Formula
C24H24F5N5O
Formula Weight
493.47
MOL File
935273-79-3.mol
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MK-4101 Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
29159
Product name
MK-4101
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
29159
Product name
MK-4101
Packaging
25mg
Price
$704
Updated
2024/03/01
Cayman Chemical
Product number
29159
Product name
MK-4101
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
29159
Product name
MK-4101
Packaging
10mg
Price
$301
Updated
2024/03/01
ChemScene
Product number
CS-5749
Product name
MK-4101
Purity
98.31%
Packaging
50mg
Price
$420
Updated
2021/12/16
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MK-4101 Chemical Properties,Usage,Production

Biological Activity

mk-4101 is a hedgehog (hh) signaling pathway inhibitor.abnormal activation of the hedgehog (hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.

in vitro

mk-4101 was found to target the hh pathway in tumor cells, with the maximum inhibitory effect on gli1. mk-4101 could also induce the deregulation of cell cycle and block of dna replication in tumors. in addition, members of the igf and wnt signaling pathways were among the most highly deregulated genes by mk-4101, indicating that the interplay among hh, igf, and wnt was critical in hh-dependent tumorigenesis [1].

in vivo

in a previous study, using neonatally irradiated ptch1(+/-) mice as a model of hh-dependent tumors, the in vivo effects of mk-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. results showed a potent antitumor activity of mk-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. moreover, beside antitumor activity on transplanted tumors, mk-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].

target

IC 50

1.5 μmol/l for in mouse light ii cells by gli_luc assay

References

[1] filocamo g et al. mk-4101, a potent inhibitor of the hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. mol cancer ther. 2016 jun;15(6):1177-89.

MK-4101 Preparation Products And Raw materials

Raw materials

Preparation Products

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935273-79-3, MK-4101Related Search:

Ethyl nonafluorobutyl ether Cyclobutyl bromide Obeticholic Acid XL147 4-Piperidinol, 4-methyl-, hydrochloride (1:1) Z-ALA-OSU mk-1064 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK 0557 MK-0812 (Succinate) MKC9989 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) MK-8998 MK8745 MK-5172 MK-2206 2HCl

  • MK-4101
  • MK4101;MK 4101;MK-4101
  • 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
  • 1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-
  • Apoptosis,inhibit,MK4101,Smoothened,MK-4101,MK 4101,Hedgehog,Inhibitor,Smo
  • 935273-79-3
  • C24H24F5N5O
    • TargetValue
    SMO
    ()