Description Referrence
ChemicalBook > CAS DataBase List > 4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid

Description Referrence
Product Name
4-Hydroxyphenylacetic acid
CAS No.
156-38-7
Chemical Name
4-Hydroxyphenylacetic acid
Synonyms
P-HYDROXYPHENYLACETIC ACID;PHPA;2-(4-hydroxyphenyl)acetic acid;4-Hydroxybenzeneacetic acid;4-carboxymethylphenol;4-Hydroxyphenylacetic;4-hydrophenylacetic acid;4-hydroxybenzeneaceticacid;Benzeneacetic acid, 4-hydroxy-;NSC 27460
CBNumber
CB6314323
Molecular Formula
C8H8O3
Formula Weight
152.15
MOL File
156-38-7.mol
More
Less

4-Hydroxyphenylacetic acid Property

Melting point:
148-151 °C(lit.)
Boiling point:
234.6°C (rough estimate)
Density 
1.2143 (rough estimate)
vapor pressure 
0.007Pa at 25℃
refractive index 
1.4945 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
50g/l
pka
4.50±0.10(Predicted)
form 
Crystalline Powder
color 
White to cream or light tan
PH
2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility 
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 
1448766
InChIKey
XQXPVVBIMDBYFF-UHFFFAOYSA-N
LogP
0.75 at 25℃
CAS DataBase Reference
156-38-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System
Benzeneacetic acid, 4-hydroxy- (156-38-7)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
AI2680000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29182990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H50004
Product name
4-Hydroxyphenylacetic acid
Purity
98%
Packaging
5g
Price
$28
Updated
2024/03/01
Sigma-Aldrich
Product number
H50004
Product name
4-Hydroxyphenylacetic acid
Purity
98%
Packaging
25g
Price
$51.1
Updated
2024/03/01
Sigma-Aldrich
Product number
55206
Product name
4-Hydroxyphenylacetic acid
Purity
analytical standard
Packaging
10MG
Price
$53.5
Updated
2022/05/15
Sigma-Aldrich
Product number
55206
Product name
4-Hydroxyphenylacetic acid
Purity
analytical standard
Packaging
50MG
Price
$108
Updated
2022/05/15
TCI Chemical
Product number
H0290
Product name
4-Hydroxyphenylacetic Acid
Purity
>99.0%(GC)(T)
Packaging
25g
Price
$22
Updated
2024/03/01
More
Less

4-Hydroxyphenylacetic acid Chemical Properties,Usage,Production

Description

4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.

Referrence

  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.

Chemical Properties

4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.

Uses

It is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes.

Uses

A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.

Preparation

4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.
4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.

Definition

ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

4-Hydroxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Glyoxal Phenol 4-Aminophenylacetic acid Glyoxylic acid

Preparation Products

2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate Methyl 4-hydroxyphenylacetate Ethyl 4-hydroxyphenylacetate Cefprozil hydrate Isobutylparaben Camostat 4-Hydroxyphenylacetamide Bufexamac P-TOLYL-ACETYL CHLORIDE 4-METHOXYPHENYLACETYL CHLORIDE
More
Less

4-Hydroxyphenylacetic acid Suppliers

Americas 1 Austria 1 Belgium 1 Canada 3 China 571 Czech Republic 1 Europe 4 France 4 Germany 10 India 52 Japan 12 Norway 1 Slovakia 1 South Korea 1 Switzerland 6 The Netherlands 1 Ukraine 1 United Kingdom 20 United States 64 Global 755
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Richman Chemical Inc.
Tel
--
Fax
--
Email
kac@richmanchemical.com
Country
United States
ProdList
692
Advantage
67
EJY Tech, Inc.
Tel
--
Fax
--
Country
United States
ProdList
448
Advantage
30
RSA Corporation
Tel
--
Fax
--
Email
media@RSAgroup.ca
Country
United States
ProdList
343
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
CALSAK CORPORATION
Tel
--
Fax
--
Email
calsak@calsak.com
Country
United States
ProdList
430
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Sarchem Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
349
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
Cerilliant Corporation
Tel
--
Fax
--
Email
techserv@cerilliant.com
Country
United States
ProdList
1629
Advantage
69
More
Less

View Lastest Price from 4-Hydroxyphenylacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-27
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-03
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-Hydroxyphenylacetic acid 156-38-7
Price
US $980.00-750.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15

156-38-7, 4-Hydroxyphenylacetic acidRelated Search:

4-Hydroxybenzyl cyanide Folic acid Stearic acid 4'-Hydroxyacetophenone p-(2-Methoxyethyl) phenol 2,2-Diphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate 2-Methylphenylacetic acid Tyramine 3,4-Dihydroxyphenylacetic acid 2-(4-HYDROXYPHENYL)ACETALDEHYDE Citric acid Phenethyl phenylacetate 4-Hydroxyphenylacetamide 4-Hydroxyphenethyl alcohol 4-Nitrophenyl chloroformate Ascoric Acid Methylparaben

  • (p-hydroxyphenyl)-aceticaci
  • 4-carboxymethylphenol
  • 4-Hydroxybenzeneacetic acid
  • 4-Hydroxyphenylacetic acid Vetec(TM) reagent grade, 98%
  • Arbidol Impurity F HCl
  • Levothyroxine Sodium Impurity d
  • NSC 27460
  • Acetic acid, (p-hydroxyphenyl)-
  • ethanoicacid,4-hydroxyphenyl-
  • Parahydroxy phenylacetic acid
  • RARECHEM AL BO 0188
  • P-HYDROPHENYLACETIC ACID
  • P-HYDROXYPHENYLACETIC ACID
  • PHPA
  • AKOS 236-100
  • 4-HYDROXYPHENYLACETIC ACID
  • 4-HYDROXYPHENYLACETIC ACID, FOR FLUORESC ENCE
  • 4-HydroxyphenylacetidAcid
  • Atenolol Impurity (4-Hydroxyphenylacetic
  • Atenolol Impurity K
  • 4-hydrophenylacetic acid
  • 4-Hydroxyphenylacetic acid,98%
  • HYDROXYPHENYLACETIC ACID, 4-(RG)
  • 4-Hydroxyphenylacetic acid, 98% 100GR
  • Atenolol iMpurity F(4-Hydroxyphenylacetic acid)
  • 4-hydroxy-benzeneaceticaci
  • 4-hydroxybenzeneaceticacid
  • 4-hydroxyphenylethanoicacid
  • Hydroxyphenylacetic aci
  • 4-Hdroxyphenylacetic acid
  • The hydroxy benzene acetic acid
  • Benzeneacetic acid, 4-hydroxy-
  • 2-(4-hydroxyphenyl)acetic acid
  • 4-Hydroxyphenylacetic acid 98%
  • 4-Hydroxyphenylacetic
  • p-Hydroxybenzeneacetic acid
  • 4-HydroxyphenylaceticAcid&gt
  • parahydroxy phenylacetate
  • Name 4-Hydroxyphenylacetic acid
  • 4-Hydroxyphenylacetin acid
  • Atenolol Impurity 12
  • p-Hydroxyphenylessigsure
  • Qulaity Guaranteed Intermediate Powder 4-Hydroxyphenylacetic Acid CAS 156-38-7 C8h8o3 with Fast Delivery
  • 4-Hydroxyphenylacetic Acid D4
  • 4-Hydroxyphenylacetic acid, 97%+
  • 4-Hydroxyphenylacetic acid in methanol
  • 4-hydroxyphenylacetic acid, 10 mM in DMSO
  • 156-38-7
  • HOC6H4CH2CO2H
  • Other Fluorescent Labels
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Labels
  • Biochemicals and Reagents
  • BioChemical
  • CARBOXYLIC ACID
  • C8Fluorescent Probes, Labels, Particles and Stains
  • Other Fluorescent Labels
  • Carbonyl Compounds