ChemicalBook > CAS DataBase List > Ethyl 2-aminothiophene-3-carboxylate
Ethyl 2-aminothiophene-3-carboxylate
- Product Name
- Ethyl 2-aminothiophene-3-carboxylate
- CAS No.
- 31891-06-2
- Chemical Name
- Ethyl 2-aminothiophene-3-carboxylate
- Synonyms
- AKOS B014694;BUTTPARK 33\06-04;ART-CHEM-BB B014694;ASINEX-REAG BAS 11719538;2-AMino-3-carboethoxythiophene;2-AMINOTHIOPHENE-3-CARBOXYLATE;2-aminothiophene-3-ethyl formate;2-AMINO-3-ETHOXYCARBONYLTHIOPHENE;Ethy 2-aminothiophene-3-carboxylate;Ethyl 2-amino-3-thiophenecarboxylate
- CBNumber
- CB6315067
- Molecular Formula
- C7H9NO2S
- Formula Weight
- 171.22
- MOL File
- 31891-06-2.mol
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Ethyl 2-aminothiophene-3-carboxylate Property
- Melting point:
- 42 °C
- Boiling point:
- 273.6±20.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform, Dichloromethane
- form
- Solid
- pka
- 0.11±0.10(Predicted)
- color
- Brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H9NO2S/c1-2-10-7(9)5-3-4-11-6(5)8/h3-4H,2,8H2,1H3
- InChIKey
- MKJQYFVTEPGXIE-UHFFFAOYSA-N
- SMILES
- C1(N)SC=CC=1C(OCC)=O
- CAS DataBase Reference
- 31891-06-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Usbiological
- Product number
- E8603-75
- Product name
- Ethyl 2-Aminothiophene-3-carboxylate
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
TRC
- Product number
- E899325
- Product name
- Ethyl2-Aminothiophene-3-carboxylate
- Packaging
- 10g
- Price
- $1010
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 9998
- Product name
- Ethyl2-Aminothiophene-3-carboxylate
- Packaging
- 5G
- Price
- $1720
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0029585
- Product name
- ETHYL 2-AMINOTHIOPHENE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2148.3
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000473716
- Product name
- Ethyl 2-aminothiophene-3-carboxylate
- Purity
- 97%
- Packaging
- 100g
- Price
- $123
- Updated
- 2021/12/16
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Ethyl 2-aminothiophene-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Ethyl 2-aminothiophene-3-carboxylate is used as an organic chemical synthesis intermediate.
Synthesis
40018-26-6
105-56-6
31891-06-2
The general procedure for the synthesis of ethyl 2-aminothiophene-3-carboxylate from 1,4-dithio-2,5-diol and ethyl cyanoacetate was as follows: in a 2-5 mL microwave reaction flask, ethyl cyanoacetate (0.22 mmol, 1.0 equiv.) and trifluoroethanol (2 mL) were added, and stirred for 2 min until complete dissolution. Subsequently, 1,4-dithio-2,5-diol (0.11 mmol, 0.5 eq.) was added and stirring was continued for 5 min. Next, triethylamine (0.242 mmol, 1.1 eq.) was added and the reaction mixture was stirred for another 2 minutes. The reaction flask was sealed and placed in a microwave reactor and heated at 60 °C for 390 min. After completion of the reaction, the solvent was removed by vacuum evaporation. The crude product was purified by silica gel fast column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product ethyl 2-aminothiophene-3-carboxylate.
References
[1] Synthesis (Germany), 2013, vol. 45, # 1, p. 45 - 52
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5437 - 5447
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 875 - 883
[4] Chemical Communications, 2013, vol. 49, # 2, p. 190 - 192
[5] Archiv der Pharmazie, 2011, vol. 344, # 7, p. 459 - 465
Ethyl 2-aminothiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-aminothiophene-3-carboxylate manufacturers
Career Henan Chemical Co
- Product
- Ethyl 2-aminothiophene-3-carboxylate 31891-06-2
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2019-12-20
31891-06-2, Ethyl 2-aminothiophene-3-carboxylateRelated Search:
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