1,4-Benzodioxane-6-carboxylic acid
- Product Name
- 1,4-Benzodioxane-6-carboxylic acid
- CAS No.
- 4442-54-0
- Chemical Name
- 1,4-Benzodioxane-6-carboxylic acid
- Synonyms
- AKOS B013959;AKOS BBS-00005369;BUTTPARK 85\15-10;TIMTEC-BB SBB007047;RARECHEM AL BO 1905;1,4-Benzodioxane-6-;CHEMBRDG-BB 4003145;ART-CHEM-BB B013959;1,4-Benzodioxane-6-c;1,4-Benzodioxane-6-carboxyL
- CBNumber
- CB6326229
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 4442-54-0.mol
1,4-Benzodioxane-6-carboxylic acid Property
- Melting point:
- 134-138 °C(lit.)
- Boiling point:
- 339.8±41.0 °C(Predicted)
- Density
- 1.376±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 4.37±0.20(Predicted)
- form
- Crystalline Solid
- color
- Pale brown
- InChIKey
- JWZQJTGQFHIRFQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 4442-54-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 658375
- Product name
- 1,4-Benzodioxane-6-carboxylic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $172
- Updated
- 2025/07/31
- Product number
- 658375
- Product name
- 1,4-Benzodioxane-6-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $177
- Updated
- 2025/07/31
- Product number
- B3764
- Product name
- 1,4-Benzodioxane-6-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- B3764
- Product name
- 1,4-Benzodioxane-6-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $223
- Updated
- 2025/07/31
- Product number
- E917795
- Product name
- 3,4-EthylenedioxybenzoicAcid
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
1,4-Benzodioxane-6-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
3,4-Ethylenedioxybenzoic Acid is used in the preparation of new anti-inflammatory compounds containing the 1,4-benzodioxine system.
Uses
1,4-Benzodioxane-6-carboxylic Acid is used in the preparation of new anti-inflammatory compounds containing the 1,4-benzodioxine system.
Synthesis
29668-44-8
4442-54-0
General procedure for the synthesis of 1,4-benzodioxane-6-carboxylic acid from 1,4-benzodioxane-6-carboxaldehyde: To a 20 mL methanol solution of urea-hydrogen peroxide complex (1:1) (6 g, 63.4 mmol) and aldehydes 3a-f (4.28 mmol) in stirring was added an aqueous NaOH solution (1.6 mL, 6 M solution). The reaction mixture was refluxed and stirred for 1 h at room temperature, followed by the addition of urea-hydrogen peroxide complex (1.5 g, 15.85 mmol) and continued refluxing for 30 min. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 3 with 18% aqueous HCl. The precipitates were collected by filtration, washed with 2 x 50 mL of ice water and dried to give 4a-f (82-94% yield) as an off-white solid. For compound 4e, the reaction mixture was cooled at room temperature and the pH was adjusted to 3 with 18% HCl aqueous solution. methanol was removed by evaporation and the mixture was subsequently diluted with 30 mL of water and extracted with CHCl3. The organic phase was washed with water and the solvent was evaporated and dried.
References
[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 6, p. 1578 - 1581
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 11, p. 1951 - 1964
[4] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 1, p. 71 - 85
[5] Patent: US5530028, 1996, A
1,4-Benzodioxane-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-Benzodioxane-6-carboxylic acid manufacturers
- Product
- 1,4-Benzodioxane-6-carboxylic acid 4442-54-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24