ChemicalBook > CAS DataBase List > SMI-16a

SMI-16a

Product Name: SMI-16a
CAS No.: 587852-28-6
Chemical Name: SMI-16a
Synonyms: SMI-16a;SMI-16a, 10 mM in DMSO;SMI-16A;SMI 16A;SMI16A;PIM1/2 Kinase Inhibitor VI;SMI-16a(PIM1/2 Kinase Inhibitor VI);5-(4-propoxybenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-;SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases
CBNumber: CB63313558
Molecular Formula: C13H13NO3S
Formula Weight: 263.31
MOL File: 587852-28-6.mol

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SMI-16a Property

Melting point:: 186.3-188.4 °C
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM)
form: A solid
pka: 7.27±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 526524
Product name: PIM1/2 Kinase Inhibitor VI
Purity: The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor
Packaging: 5 mg
Price: $126
Updated: 2025/07/31

Cayman Chemical

Product number: 29456
Product name: SMI-16a
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29456
Product name: SMI-16a
Packaging: 25mg
Price: $365
Updated: 2024/03/01

Cayman Chemical

Product number: 29456
Product name: SMI-16a
Packaging: 10mg
Price: $166
Updated: 2024/03/01

ChemScene

Product number: CS-6913
Product name: SMI-16a
Purity: 99.70%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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SMI-16a Chemical Properties,Usage,Production

Description

SMI-16a is a Pim-1 kinase inhibitor (IC₅₀ = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G₁ phase in DU145 cells.

Uses

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

in vivo

Mice tolerate intraperitoneal dose of SMI-16a is 50 mg/kg daily for 5 days, while 100 mg/kg is overtly toxic. Treatment of the animals with SMI-16a for 5 days per week reduces the growth of tumors by approximately 50% and does not cause a loss of body weight. Subchronic dosing with SMI-16a does not affect the levels of red, white blood cells, including lymphocytes, monocytes, and granulocytes, indicating that the compound does not have myelosuppressive effects. SMI-16a does not have toxicity toward the liver as the albumin, alkaline phosphatase, and alanine aminotransferase levels are unchanged ^[1]. SMI-16a effectively prevents bone destruction while suppressing MM tumor growth in MM animal models^[2].

IC 50

PIM1; PIM2

References

[1] Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86. DOI:10.1021/jm800937p
[2] Hiasa M, et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29(1):207-17. DOI:10.1038/leu.2014.147

SMI-16a Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SMI-16a manufacturers

Career Henan Chemical Co

Product: SMI-16a 587852-28-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

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SMI-16a

PIM1/2 Kinase Inhibitor VI

SMI-16a(PIM1/2 Kinase Inhibitor VI)

SMI-16A;SMI 16A;SMI16A

2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-

SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases

5-(4-propoxybenzylidene)thiazolidine-2,4-dione

SMI-16a, 10 mM in DMSO

587852-28-6