2-Methoxyethoxymethyl chloride

Product Name: 2-Methoxyethoxymethyl chloride
CAS No.: 3970-21-6
Chemical Name: 2-Methoxyethoxymethyl chloride
Synonyms: MEM CHLORIDE;1-CHLOROMETHOXY-2-METHOXYETHANE;MEM Chlordie;MEM chloride,94%;2-Methoxyethoxymethy;2-MethoxyethoxymethyL;1-Chloro-2,5-dioxahexane;Roxithromycin side chain;Roxithromycin Impurity 15;ALKOXYETHOXYMETHYLCHLORIDE
CBNumber: CB6332734
Molecular Formula: C4H9ClO2
Formula Weight: 124.57
MOL File: 3970-21-6.mol

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2-Methoxyethoxymethyl chloride Property

Melting point:: 200-202 °C
Boiling point:: 50-52 °C/13 mmHg (lit.)
Density: 1.091 g/mL at 25 °C (lit.)
refractive index: n20/D 1.427(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform, Methanol
form: Liquid
Specific Gravity: 1.091
color: Clear colorless to yellow
Water Solubility: It hydrolyzes with water.
Sensitive: Moisture Sensitive
BRN: 1900576
Exposure limits: ACGIH: TWA 0.001 ppm
InChIKey: BIAAQBNMRITRDV-UHFFFAOYSA-N
CAS DataBase Reference: 3970-21-6(CAS DataBase Reference)
NIST Chemistry Reference: «BETA»-methoxyethoxymethyl chloride(3970-21-6)
EPA Substance Registry System: Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)

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Safety

Hazard Codes: T
Risk Statements: 45-10-36/37/38-20/21/22-46-40-23/24/25-20/22
Safety Statements: 53-26-36/37/39-45-16-23
RIDADR: UN 2810 6.1/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Toxic
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29091990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

H350May cause cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 357480
Product name: 2-Methoxyethoxymethyl chloride
Purity: technical grade
Packaging: 5g
Price: $77.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 357480
Product name: 2-Methoxyethoxymethyl chloride
Purity: technical grade
Packaging: 25g
Price: $194
Updated: 2024/03/01

TCI Chemical

Product number: M0680
Product name: 2-Methoxyethoxymethyl Chloride
Purity: >95.0%(GC)
Packaging: 25mL
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: M0680
Product name: 2-Methoxyethoxymethyl Chloride
Purity: >95.0%(GC)
Packaging: 500mL
Price: $597
Updated: 2024/03/01

Alfa Aesar

Product number: L01050
Product name: 2-Methoxyethoxymethyl chloride, 94%
Packaging: 5g
Price: $45.65
Updated: 2024/03/01

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2-Methoxyethoxymethyl chloride Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

Uses

OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.

Uses

2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.

Purification Methods

Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.

2-Methoxyethoxymethyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Roxithromycin 3,4-DIBROMO-5-HYDROXY-5H-FURAN-2-ONE

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2-Methoxyethoxymethyl chloride Suppliers

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View Lastest Price from 2-Methoxyethoxymethyl chloride manufacturers

airuikechemical co., ltd.

Product: 2-methoxyethoxymethyl chloride 3970-21-6
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-03-28

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Methoxyethoxymethyl chloride 3970-21-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Mojin Biotechnology Co., Ltd

Product: 2-Methoxyethoxymethyl chloride 3970-21-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-09

3970-21-6, 2-Methoxyethoxymethyl chlorideRelated Search:

Mepiquat chloride 4-Methoxybenzylchloride Sodium chloride tert-Butyldimethylsilyl chloride Polyvinyl chloride Choline chloride Ammonium chloride Calcium chloride Benzyl chloride Ethoxymethylenemalononitrile DIMETHYLTHEXYLSILYL CHLORIDE 4-(Chloromethyl)benzoic acid Methylene Chloride 2-Ethoxyethyl chloroformate 1-Chloro-3,5-di-O-toluoyl-2-deoxy-D-ribofuranose TRIETHYLENE GLYCOL BIS(CHLOROFORMATE) 2-METHOXYETHYL CHLOROFORMATE Oxydiethylene bis(chloroformate)

ALKOXYETHOXYMETHYLCHLORIDE

BETA-METHOXYETHOXYMETHYL CHLORIDE

ETHYLENE GLYCOL CHLOROMETHYL METHYL ETHER

MEM CHLORIDE

1-CHLOROMETHOXY-2-METHOXYETHANE

1-(Chloromethoxy)-2-methoxyethane~MEM chloride

Alcoxyethoxymethylchloride

Methoxxxy ethoxy Chloromethane

2-Methoxyethoxymethyl chloride, technical grade

2-METHOXYETHOXYMETHYL CHLORIDE

MEM Chlordie

MEM CHLORIDE (2-METHOXYETHOXYMETHYL CHLORIDE)

METHOXYETHOXYCHLOROMETHANE

β-Methoxyethoxymethyl chloride, MEM-chloride

MEM chloride,94%

2-Methoxyethoxymethy

1-Methoxy-2-(chloromethoxy)ethane

1-(2-pyridinylsulfonyl)benzotriazole

2,5-Dioxahexyl chloride, tech

MEM chloride, 1-(Chloromethoxy)-2-methoxyethane, 2-Methoxyethoxymethyl chloride

1-Chloromethoxy-2-methoxyethane Ethylene Glycol Chloromethyl Methyl Ether MEM-Chloride

MethoxyethoxyMethylchlorid

1-(chloromethoxy)-2-methoxy-ethan

1-Chloro-2,5-dioxahexane

2-Methoxy-1-(Chloromethoxy)

Ethane, 1-(chloromethoxy)-2-methoxy-

Chloride:Alcoxyethoxylmethylchloride

2-MethoxyethoxymethylChloride&gt

2-Methoxyethoxymethyl chloride, 95%, for synthesis

2-MethoxyethoxymethyL

β-Methoxyethoxymethyl Chloride Or Mem-Chloride

2-Methoxyethyl chloromethyl ether

2-Methoxyethoxychloromethane

Roxithromycin side chain

Roxithromycin Impurity 15

3970-21-6

CH3OCH2CH2OCH2Cl

CH3OCH22OCH2Cl

C4H9ClO2

Protection and Derivatization

Protecting and Derivatizing Reagents

Others

Synthetic Reagents

Protection & Derivatization Reagents (for Synthesis)

Synthetic Organic Chemistry