ChemicalBook > CAS DataBase List > 2,6-DIAMINO-4-METHOXY PYRIMIDINE

2,6-DIAMINO-4-METHOXY PYRIMIDINE

Product Name
2,6-DIAMINO-4-METHOXY PYRIMIDINE
CAS No.
3270-97-1
Chemical Name
2,6-DIAMINO-4-METHOXY PYRIMIDINE
Synonyms
Minoxidil Impurity 41;Minoxidil Impurity 13;2,4-Diamino-6-methoxypyrimidine;2,6-DIAMINO-4-METHOXY PYRIMIDINE;6-methoxy-pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 6-methoxy-;2-AMINO-6-METHOXYPYRIMIDIN-4-YLAMINE;2,6-Diamino-4-methoxy pyrimidine ,97%;2,4-Pyrimidinediamine, 6-methoxy- (9CI);2,6-DIAMINO-4-METHOXY PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB6344559
Molecular Formula
C5H8N4O
Formula Weight
140.14
MOL File
3270-97-1.mol
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2,6-DIAMINO-4-METHOXY PYRIMIDINE Property

Melting point:
162.0 to 166.0 °C
Boiling point:
429.4±48.0 °C(Predicted)
Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
5.24±0.10(Predicted)
color 
White to Almost white
λmax
265nm(MeOH)(lit.)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5088
Product name
2,4-Diamino-6-methoxypyrimidine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$149
Updated
2025/07/31
TCI Chemical
Product number
D5088
Product name
2,4-Diamino-6-methoxypyrimidine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$445
Updated
2025/07/31
Biosynth Carbosynth
Product number
FD147833
Product name
2,6-Diamino-4-methoxypyrimidine
Packaging
250mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
Y4940
Product name
2,6-Diamino-4-methoxypyrimidine
Packaging
250mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
Y4940
Product name
2,6-Diamino-4-methoxypyrimidine
Packaging
1g
Price
$151
Updated
2021/12/16
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2,6-DIAMINO-4-METHOXY PYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

2,4-Diamino-6-methoxypyrimidine is an organic amine compound used as a raw material for organic synthesis or as a pharmaceutical intermediate ingredient. The product can be used to prepare other heterocyclic compounds or anticancer active ingredients.

Synthesis

67-56-1

156-83-2

3270-97-1

General procedure for the synthesis of 2,4-diamino-6-methoxypyrimidine from methanol and 2,4-diamino-6-chloropyrimidine: 9.2 g (0.40 mol) of sodium metal was added to a flask containing 320 mL of methanol and stirred until completely dissolved. Subsequently, 28.9 g (0.20 mol) of 2,4-diamino-6-chloropyrimidine was added to this solution. The reaction mixture was placed under reflux conditions and stirred continuously for 44 hours. Upon completion of the reaction, the precipitated sodium chloride was removed by filtration. The filtrate was concentrated to dryness to give the crude product. The crude product was dissolved in 300 mL of ethanol, heated to boiling and then thermally filtered. The filtrate was allowed to stand overnight to crystallize 2,4-diamino-6-methoxypyrimidine. The product can be further purified by recrystallization of the mother liquor. After drying, 2,4-diamino-6-methoxypyrimidine (58.8 g, 84% yield) was obtained as a white solid. Melting point: 166-169 °C. 1H-NMR (300 MHz, d6-DMSO): δ= 3.18 (s, 3H, 6-OMe), 5.06 (s, 1H, 5-H), 5.94 (s, 2H, NH2), 6.05 (s, 2H, NH2). 13C-NMR (125 MHz, d6-DMSO): δ= 52.8 ( 6-OMe), 76.1 (5-C), 163.3 (2-C), 166.3 (4-C), 170.8 (6-C).

References

[1] Organic and Biomolecular Chemistry, 2010, vol. 8, # 10, p. 2397 - 2407
[2] Patent: US2015/209257, 2015, A1. Location in patent: Paragraph 0239; 0240; 0241; 0242; 0243
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 917 - 921

2,6-DIAMINO-4-METHOXY PYRIMIDINE Preparation Products And Raw materials

Raw materials

2,4-Diamino-6-hydroxypyrimidine Toluene Sodium Phosphorus oxitrichloride Methanol Sodium carbonate

Preparation Products

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2,6-DIAMINO-4-METHOXY PYRIMIDINE Suppliers

Americas 1 China 87 Europe 2 Germany 2 India 3 Japan 1 The Netherlands 1 United Kingdom 3 United States 12 Global 112
Alchem Pharmtech,Inc.
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View Lastest Price from 2,6-DIAMINO-4-METHOXY PYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
2,6-DIAMINO-4-METHOXY PYRIMIDINE 3270-97-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-15
Career Henan Chemical Co
Product
2,6-DIAMINO-4-METHOXY PYRIMIDINE 3270-97-1
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

3270-97-1, 2,6-DIAMINO-4-METHOXY PYRIMIDINERelated Search:

2,6-DIAMINO-4-METHOXY PYRIMIDINE 2,4-DIAMINO-6-ETHOXYPYRIMIDINE 2,3-Diamino-6-methoxypyridine Pyrimidine 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine 4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE CHEMPACIFIC 39933 N-[2-(DIMETHYLAMINO)-6-METHOXYPYRIMIDIN-4-YL]ACETAMIDE N-(2-AMINO-6-METHOXY-5-NITROSOPYRIMIDIN-4-YL)-N-METHYLAMINE 2,4-DIAMINO-5-(NITRO)-6-(METHYLOXY)PYRIMIDINE 2-AMINO-6-(2,4-DICHLOROPHENOXY)PYRIMIDIN-4-YLAMINE 2-AMINO-4-METHOXY-6-MORPHOLIN-4-YLPYRIMIDINE-5-CARBALDEHYDE 2-AMINO-4-METHOXY-6-PYRROLIDIN-1-YLPYRIMIDINE-5-CARBALDEHYDE N-[2-(ACETYLAMINO)-6-METHOXY-4-PYRIMIDINYL]ACETAMIDE N-[4-AMINO-5-NITROSO-6-(PENTYLOXY)PYRIMIDIN-2-YL]-N-METHYLAMINE N-(2-AMINO-6-METHOXY-5-NITROSOPYRIMIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE 2,4-diamino-6-(benzyloxy)pyrimidine-5-carbonitrile 4-AMINO-2-(DIMETHYLAMINO)-5-(NITRO)-6-(METHYLOXY)PYRIMIDINE

  • 2,6-DIAMINO-4-METHOXY PYRIMIDINE
  • 2-AMINO-6-METHOXYPYRIMIDIN-4-YLAMINE
  • 2,4-Pyrimidinediamine, 6-methoxy- (9CI)
  • 2,6-Diamino-4-methoxy pyrimidine ,97%
  • 2,4-Diamino-6-methoxypyrimidine
  • 6-methoxy-pyrimidine-2,4-diamine
  • 2,4-Pyrimidinediamine, 6-methoxy-
  • 2,6-DIAMINO-4-METHOXY PYRIMIDINE ISO 9001：2015 REACH
  • Minoxidil Impurity 13
  • Minoxidil Impurity 41
  • 3270-97-1
  • 36315-02-1
  • PYRIMIDINE