5-Fluorouridine
- Product Name
- 5-Fluorouridine
- CAS No.
- 316-46-1
- Chemical Name
- 5-Fluorouridine
- Synonyms
- FUR;5-FU;FURD;5-fur;5-FUrd;NSC 146604;NSC 519273;FLUOROURIDINE;5-FLUOROIDINE;5-fluoro-uridin
- CBNumber
- CB6346346
- Molecular Formula
- C9H11FN2O6
- Formula Weight
- 262.19
- MOL File
- 316-46-1.mol
5-Fluorouridine Property
- Melting point:
- 182-184 °C
- alpha
- 17 º (c=2, water 25 ºC)
- Density
- 1.4200 (estimate)
- refractive index
- 18 ° (C=1, H2O)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
- pka
- 7.63±0.10(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- soluble
- BRN
- 33662
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 316-46-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 40-68-36/37/38
- Safety Statements
- 22-26-36/37-36/37/39-27-24/25
- WGK Germany
- 3
- RTECS
- YU8050000
- F
- 10
- Hazard Note
- Harmful
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F5130
- Product name
- 5-Fluorouridine
- Purity
- proapoptotic anitproliferative plant growth regulator
- Packaging
- 100mg
- Price
- $124
- Updated
- 2024/03/01
- Product number
- F5130
- Product name
- 5-Fluorouridine
- Purity
- proapoptotic anitproliferative plant growth regulator
- Packaging
- 1g
- Price
- $683
- Updated
- 2024/03/01
- Product number
- F0636
- Product name
- 5-Fluorouridine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- F0636
- Product name
- 5-Fluorouridine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $149
- Updated
- 2024/03/01
- Product number
- J62083
- Product name
- 5-Fluorouridine, 97%
- Packaging
- 1g
- Price
- $56.65
- Updated
- 2024/03/01
5-Fluorouridine Chemical Properties,Usage,Production
Description
5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
Chemical Properties
White Powder
Uses
Antihypertensive
Uses
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.
Uses
5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).
Definition
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.
General Description
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.
Biochem/physiol Actions
5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
Purification Methods
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]
References
1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297
5-Fluorouridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluorouridine manufacturers
- Product
- 5-Fluorouridine 316-46-1
- Price
- US $54.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-03-16
- Product
- 5-Fluorouridine 316-46-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 5-Fluorouridine 316-46-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07