ChemicalBook > CAS DataBase List > 5-Fluorouridine

5-Fluorouridine

Product Name
5-Fluorouridine
CAS No.
316-46-1
Chemical Name
5-Fluorouridine
Synonyms
FUR;5-FU;FURD;5-fur;5-FUrd;NSC 146604;NSC 519273;FLUOROURIDINE;5-FLUOROIDINE;5-fluoro-uridin
CBNumber
CB6346346
Molecular Formula
C9H11FN2O6
Formula Weight
262.19
MOL File
316-46-1.mol
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5-Fluorouridine Property

Melting point:
182-184 °C
alpha 
17 º (c=2, water 25 ºC)
Density 
1.4200 (estimate)
refractive index 
18 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
pka
7.63±0.10(Predicted)
form 
Powder
color 
White
Water Solubility 
soluble
BRN 
33662
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference
316-46-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
40-68-36/37/38
Safety Statements 
22-26-36/37-36/37/39-27-24/25
WGK Germany 
3
RTECS 
YU8050000
F 
10
Hazard Note 
Harmful
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F5130
Product name
5-Fluorouridine
Purity
proapoptotic anitproliferative plant growth regulator
Packaging
100mg
Price
$124
Updated
2024/03/01
Sigma-Aldrich
Product number
F5130
Product name
5-Fluorouridine
Purity
proapoptotic anitproliferative plant growth regulator
Packaging
1g
Price
$683
Updated
2024/03/01
TCI Chemical
Product number
F0636
Product name
5-Fluorouridine
Purity
>98.0%(T)
Packaging
1g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
F0636
Product name
5-Fluorouridine
Purity
>98.0%(T)
Packaging
5g
Price
$149
Updated
2024/03/01
Alfa Aesar
Product number
J62083
Product name
5-Fluorouridine, 97%
Packaging
1g
Price
$56.65
Updated
2024/03/01
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5-Fluorouridine Chemical Properties,Usage,Production

Description

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

Chemical Properties

White Powder

Uses

Antihypertensive

Uses

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

Uses

5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).

Definition

ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.

General Description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Purification Methods

5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]

References

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

5-Fluorouridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Fluorouridine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Fluorouridine 316-46-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
5-Fluorouridine 316-46-1
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100g , 1kg, 5kg , 50kg
Release date
2020-01-07

316-46-1, 5-Fluorouridine Related Search:

5-Fluorouracil 5-Fluorouridine Floxuridine 2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE) 5'-DEOXY-5-FLUOROURIDINE DMT-2′Fluoro-dU Phosphoramidite Uracil 5-Fluoropyrimidine 5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine 2',3'-DIDEOXY-3'-FLUOROURIDINE 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine 2'-DEOXY-5-FLUOROURIDINE, [3H]- 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 2',3'-dideoxy-5-fluorouridine 5-Fluorouridine 2'-Deoxy-5-fluorouridine 3',5'-dioctanoate 2'-Deoxy-5-fluorouridine 3',5'-dibutanoate 5'-O-(9-Octadecenoyl)-5-fluorouridine

  • 1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1
  • 5-fluoro-uridin
  • 5-fur
  • Uridine, 5-fluoro-
  • FURD
  • FLUOROURIDINE
  • 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
  • 5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL
  • 5-FU
  • 5-FLUOROURACIL-1BETA-D-RIBOFURANOSIDE
  • 2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE
  • 5-fluorouracil 1β-d-ribofuranoside
  • 5-Fluorouridine97%
  • 5-FLUOROURIDINE, 98+%
  • 5-Fluorouridine
  • 5-FLUOROIDINE
  • (2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
  • 1-(beta-D-Ribofuranosyl)-5-fluorouracil
  • 5-FLUOROURIDINE extrapure
  • 5-Fluorouracil 1β-D-ribofuranoside, FUrd
  • 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
  • 5-FLUOROURIDINE, 99+%
  • FUR
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-fluoropyriMidine-2,4(1H,3H)-dione
  • 5-FUrd
  • NSC 146604
  • NSC 519273
  • FUrd 1-(beta-D-Ribofuranosyl)-5-fluorouracil
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3
  • 5-Fluorouridine&gt
  • 5-Fluorouridine USP/EP/BP
  • 5-Fluorouridine (5-FUrd) extrapure, 98%
  • 5-Fluorouridine, impurity of 5-fluorouracil
  • 5- fluorouracil nucleoside
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 316-46-1
  • C9H11FN2O6
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