ChemicalBook > CAS DataBase List > Boc-Tyr(Me)-OH

Boc-Tyr(Me)-OH

Product Name
Boc-Tyr(Me)-OH
CAS No.
53267-93-9
Chemical Name
Boc-Tyr(Me)-OH
Synonyms
Boc-Tyr(Me);BOC-L-TYR(ME);BOC-TYR(ME)-OH;Boc-O-Me-L-Tyr;BOC-L-TYR(ME)-OH;BOC-S-TYR(ME)-OH;BOC-PHE(4-OME)-OH;Boc-4-Methoxy-Phe;BOC-L-4-METHOXYPHE;BOC-TYROSINE(ME)-OH
CBNumber
CB6361822
Molecular Formula
C15H21NO5
Formula Weight
295.33
MOL File
53267-93-9.mol
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Boc-Tyr(Me)-OH Property

Boiling point:
462.0±40.0 °C(Predicted)
Density 
1.168±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.00±0.10(Predicted)
form 
Solid
color 
White to off-white
optical activity
Consistent with structure
InChI
InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)9-10-5-7-11(20-4)8-6-10/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m0/s1
InChIKey
SLWWWZWJISHVOU-LBPRGKRZSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
53267-93-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53071
Product name
Boc-Tyr(Me)-OH
Purity
Novabiochem?
Packaging
5G
Price
$316
Updated
2025/07/31
TCI Chemical
Product number
D6223
Product name
Boc-Tyr(Me)-OH
Packaging
5G
Price
$113
Updated
2025/07/31
TCI Chemical
Product number
D6223
Product name
Boc-Tyr(Me)-OH
Packaging
25G
Price
$339
Updated
2025/07/31
TRC
Product number
B391930
Product name
Boc-Tyr(Me)-OH
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B391930
Product name
Boc-Tyr(Me)-OH
Packaging
500mg
Price
$55
Updated
2021/12/16
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Boc-Tyr(Me)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-Tyr(Me)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Application

Boc-Tyr(Me)-OH, also known as N-Boc-O-methyl-L-tyrosine, is used to incorporate O-methyltyrosine, a structural component of many potent vasopressin antagonists and oxytocin antagonists.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

94790-24-6

53267-93-9

To a solution of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propionate (498 mg, 1.61 mmol) in THF/MeOH/H2O (3:1:1, 5 mL) was added LiOH-H2O (142 mg, 3.22 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h and then evaporated to remove the organic solvent. The residue was treated with 15% aqueous citric acid solution, adjusting the pH to 3, and subsequently extracted with ethyl acetate (35 mL). The combined organic layers were washed with brine (5 mL), dried over anhydrous Na2SO4 and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether=2:1) to afford (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid (466 mg, 98%) as a colorless oil.1H NMR (300 MHz, CD3OD): δ 7.13 (2H, d, J=8.4 Hz), 6.82 (2H d, J=8.4 Hz), 4.31-4.29 (1H, m), 3.73 (3H, s), 3.08 (1H, dd, J=13.8, 4.5 Hz), 2.85 (1H, dd, J=13.5, 8.7 Hz), 1.38 (9H, s).13C NMR (75 MHz, CD3OD): δ 175.42, 159.95, 157.00, 159.95, 157.00 (9H, s). 159.95, 157.67, 131.27, 130.37, 114.81, 80.50, 56.37, 55.64, 37.86, 28.67.

References

[1] Tetrahedron, 2014, vol. 70, # 37, p. 6630 - 6640
[2] Patent: CN107353239, 2017, A. Location in patent: Paragraph 0173; 0174
[3] Patent: CN107468690, 2017, A. Location in patent: Paragraph 0173; 0174
[4] Synthesis, 1984, vol. NO. 7, p. 572 - 574
[5] Journal of Organic Chemistry, 1981, vol. 46, # 9, p. 1944 - 1946

Boc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-Tyr(Me)-OH manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Boc-O-methyl-L-tyrosine 53267-93-9
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-06
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Tyr(me)-OH 53267-93-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-26
Henan Aochuang Chemical Co.,Ltd.
Product
Boc-O-methyl-L-tyrosine 53267-93-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

53267-93-9, Boc-Tyr(Me)-OHRelated Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine 6-Aminocaproic acid 4-Nitro-3-phenyl-L-alanine H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH Glycine N-Carbobenzyloxyglycine Boc-D-Tyr-OH tert-Butanol Methylparaben Methyl acrylate Bensulfuron methyl Kresoxim-methyl BOC-L-Tyrosine Phenprobamate L-Tyrosine Boc-Aib-OH L-Phenylalanine Boc-2-Methyl-D-beta-phenylalanine

  • BOC-O-METHYL-L-TYROSINE
  • BOC-PHE(4-OME)-OH
  • BOC-P-METHOXY-PHE-OH
  • BOC-L-TYR(ME)
  • BOC-L-TYR(ME)-OH
  • BOC-L-4-METHOXYPHE
  • BOC-4-METHOXYPHENYLALANINE
  • BOC-4-METHOXY-PHE-OH
  • (S)-N-alpha-Tert-butyloxycarbonyl-O-methyltyrosine
  • N-ALPHA-T-BUTYLOXYCARBONYL-O-METHYL-L-TYROSINE
  • NALPHA-tert-Butoxycarbonyl-O-methyl-L-tyrosine
  • (S)-BOC-4-METHOXYPHENYLALANINE
  • N-(tert-butoxycarbonyl)-4-methoxyphenylalanine
  • N-(tert-butoxycarbonyl)-O-methyl-L-tyrosine
  • (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid
  • boc-4-Methoxy-phe-ohboc-tyr(me)-oh
  • Boc-Tyr(Me)
  • N-Boc-O-Methyl-L-tyrosine, 98%
  • 3-(4-methoxyphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid
  • N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-Tyrosine
  • (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID
  • (S)-N-ALPHA-T-BUTYLOXYCARBONYL-O-METHYL-TYROSINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-METHYL-L-TYROSINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-TYROSINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-METHY-L-TYROSINE
  • N-ALPHA-T-BOC-P-METHOXY-L-PHENYLALANINE
  • N-ALPHA-T-BOC-O-METHYL-L-TYROSINE
  • N-ALPHA-T-BUTOXYCARBONYL-4-METHOXY-L-PHENYLALANINE
  • Boc-O-methyl-L-tyrosine≥ 99% (HPLC)
  • Boc-p-methoxy-L-Phe-OH
  • BOC-S-TYR(ME)-OH
  • BOC-TYR(ME)-OH
  • BOC-TYROSINE(ME)-OH
  • Boc-4-Methoxy-Phe
  • (Tert-Butoxy)Carbonyl Tyr(Me)-OH
  • L-4'-METHOXY-N-BOC-TYROSINE
  • Boc-O-Me-L-Tyr
  • L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-
  • Boc-O-methyl-L-tyrosine USP/EP/BP
  • Boc-L-4-Methoxyphenylalanine DCHA salt
  • Boc-O-methyl-L-tyrosine - 5 g
  • N-Boc-O-methyl-L-tyrosine
  • 53267-93-9
  • Peptide Synthesis
  • Specialty Synthesis
  • Tyrosine
  • Amino Acid Derivatives
  • Boc-Amino acid series
  • Phenylalanine [Phe, F]
  • Unusual Amino Acids
  • Boc-Amino Acids and Derivative