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2-Amino-3-fluorobenzoic acid

Application
Product Name
2-Amino-3-fluorobenzoic acid
CAS No.
825-22-9
Chemical Name
2-Amino-3-fluorobenzoic acid
Synonyms
Diaphonic acid;BUTTPARK 22\01-93;uorobenzenecarboxyL;2-AMino-3-fluorobenz;2-AMINO-3-FLUOROBENZOIC;3-FLUOROANTHRANILIC ACID;3-FluoroanthranilicAcid>2-Amino-3-fluorobenzoicAci;2-AMINO-3-FLUOROBENZOIC ACID;2-Amino-3-Fluoride Benzoic Acids
CBNumber
CB6368755
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
825-22-9.mol
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2-Amino-3-fluorobenzoic acid Property

Melting point:
171-172°C
Boiling point:
294.4±25.0 °C(Predicted)
Density 
1.430±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.60±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C7H6FNO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey
KUHAYJJXXGBYBW-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(F)=C1N
CAS DataBase Reference
825-22-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-24/25
HazardClass 
IRRITANT
HS Code 
29223990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0570
Product name
3-Fluoroanthranilic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
F0570
Product name
3-Fluoroanthranilic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$107
Updated
2025/07/31
TRC
Product number
A634628
Product name
2-Amino-3-fluorobenzoicAcid
Packaging
250mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
008762
Product name
2-Amino-3-fluorobenzoic acid
Purity
98%
Packaging
25g
Price
$58
Updated
2021/12/16
AK Scientific
Product number
L162
Product name
2-Amino-3-fluorobenzoicacid
Packaging
1g
Price
$64
Updated
2021/12/16
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2-Amino-3-fluorobenzoic acid Chemical Properties,Usage,Production

Application

2-Amino-3-fluorobenzoic acid is a carboxylic acid derivative and can be used as a pharmaceutical intermediate.

Chemical Properties

white to light yellow crystal powder

Synthesis

317-20-4

825-22-9

7-Fluoro-1H-indole-2,3-dione (13.0 g, 78.7 mmol) was used as raw material, which was dissolved in 10N sodium hydroxide solution (125 mL), heated to 70°C and stirred for 1 hour. At the same temperature, 30% hydrogen peroxide solution (25 mL) was added slowly and dropwise over 20 minutes and the reaction continued to be stirred at 70 °C for 1 hour. Upon completion of the reaction, the reaction solution was cooled in an ice bath and concentrated. Subsequently, hydrochloric acid was slowly added to adjust the pH of the solution to 4. The organic phase was extracted with ethyl acetate, and the extract was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. The crystals were collected by filtration to finally obtain 2-amino-3-fluorobenzoic acid (7.15 g, 59% yield). The NMR hydrogen spectrum (CDCl3) data were as follows: δ 6.00 (2H, broad single peak), 6.60 (1H, double-triple peak, J = 5.2 Hz, 8.0 Hz), 7.16 (1H, multiple peaks, J = 1.4 Hz, 8.0 Hz, 11.2 Hz), 7.72 (1H, triple-double peaks, J = 1.4 Hz, 8.0 Hz), and one additional hydrogen signal was masked.

References

[1] Organic Syntheses, 2002, vol. 79, p. 196 - 196
[2] Patent: US2003/187014, 2003, A1
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958, vol. 148, p. 481,488
[4] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 7, p. 2151 - 2163
[5] European Journal of Medicinal Chemistry, 1994, vol. 29, # 10, p. 743 - 751

2-Amino-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-3-fluorobenzoic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
2-amino-3-fluorobenzoic acid 825-22-9
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-08-19
Shaanxi Didu New Materials Co. Ltd
Product
2-Amino-3-fluorobenzoic acid 825-22-9
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
10 Tons
Release date
2025-06-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-3-fluorobenzoic acid 825-22-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12

825-22-9, 2-Amino-3-fluorobenzoic acidRelated Search:

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  • BUTTPARK 22\01-93
  • 2-AMINO-3-FLUOROBENZENECARBOXYLIC ACID
  • 2-AMINO-3-FLUOROBENZOIC ACID
  • 3-FLUOROANTHRANILIC ACID
  • 2-AMINO-3-FLUOROBENZOIC
  • 2-Amino-3-Fluoride Benzoic Acids
  • Benzoic acid, 2-amino-3-fluoro-
  • 3-Fluoroanthranilic acid, 2-Carboxy-6-fluoroaniline
  • Diaphonic acid
  • 2-AMino-3-fluorobenz
  • 3-FluoroanthranilicAcid&gt
  • uorobenzenecarboxyL
  • 2-Amino-3-fluorobenzoicAci
  • 825-22-9
  • 825-22-5
  • Fluorin-contained Benzoic acid series
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Fluorine series