ChemicalBook > CAS DataBase List > 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

Product Name
5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE
CAS No.
163769-88-8
Chemical Name
5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE
Synonyms
YM 90709;YM 90709;YM90709;YM-90709;5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE;2,3-Dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline;Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-;YM-90709,GM-CSF,inhibit,Inhibitor,Interleukin Related,IL-5,eosinophils,IL-5R,JAK2
CBNumber
CB6394488
Molecular Formula
C22H21N3O2
Formula Weight
359.42
MOL File
163769-88-8.mol
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5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Property

Boiling point:
579.6±50.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
form 
A crystalline solid
pka
2.74±0.40(Predicted)
color 
Brown to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23448
Product name
YM-90709
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23448
Product name
YM-90709
Purity
≥98%
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
23448
Product name
YM-90709
Purity
≥98%
Packaging
25mg
Price
$365
Updated
2024/03/01
Tocris
Product number
1675
Product name
YM90709
Purity
≥99%(HPLC)
Packaging
10
Price
$220
Updated
2021/12/16
TRC
Product number
Y100630
Product name
YM90709
Packaging
100mg
Price
$650
Updated
2021/12/16
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5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Chemical Properties,Usage,Production

Description

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.

Uses

YM 90709, is an interleukin-5 receptor antagonist.

Definition

ChEBI: LSM-2128 is a quinoxaline derivative.

Biological Activity

Novel, selective inhibitor of interleukin-5 (IL-5) binding to its receptor (IC 50 = 0.45-1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. In vivo, inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways, without affecting peripheral blood or bone marrow leukocytes.

5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE Suppliers

China 42 Germany 1 India 1 United Kingdom 1 United States 13 Global 58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE manufacturers

Career Henan Chemical Co
Product
5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE 163769-88-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

163769-88-8, 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINERelated Search:

DIMETHYLCYANAMIDE Centchroman YM155 YM 26734 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride BTP2 Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate YM-53601 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM17E Methylhydrogen dichlorosilane Dimethylhydrochlorosilane 4-Hydroxyphentermine 4,7-Diazaindole 2-PHENYL-4,7-DIAZAINDOLE 1-TERT-BUTYLPYRROLE (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

  • Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-
  • 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE
  • YM 90709
  • 2,3-Dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline
  • YM 90709;YM90709;YM-90709
  • YM-90709,GM-CSF,inhibit,Inhibitor,Interleukin Related,IL-5,eosinophils,IL-5R,JAK2
  • 163769-88-8
  • API