SC-560
- Product Name
- SC-560
- CAS No.
- 188817-13-2
- Chemical Name
- SC-560
- Synonyms
- SC SC;SC-560;CS-1042;5-(4-Chlorophenyl);SC-560;SC 560;SC560;SC-560 Assay Reagent;SC-560, 10 mM in DMSO;SC-560, COX-1 inhibitor;SC-560 - CAS 188817-13-2 - Calbiochem;Cyclooxygenase,SC 560,inhibit,Inhibitor,SC-560,COX
- CBNumber
- CB6409526
- Molecular Formula
- C17H12ClF3N2O
- Formula Weight
- 352.74
- MOL File
- 188817-13-2.mol
SC-560 Property
- Melting point:
- 63 °C
- Boiling point:
- 440.6±45.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- Off-white solid
- pka
- -3?+-.0.10(Predicted)
- color
- White to Light yellow to Light orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- S2064
- Product name
- SC-560
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $247
- Updated
- 2024/03/01
- Product number
- 565610
- Product name
- SC-560
- Packaging
- 5mg
- Price
- $168
- Updated
- 2022/05/15
- Product number
- C3572
- Product name
- SC-560
- Packaging
- 25MG
- Price
- $95
- Updated
- 2024/03/01
- Product number
- C3572
- Product name
- SC-560
- Packaging
- 100MG
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 70340
- Product name
- SC-560
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $19
- Updated
- 2024/03/01
SC-560 Chemical Properties,Usage,Production
Uses
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole is used as a cyclooxygenase inhibitors on the angiogenesis and apoptosis.
Uses
SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos. It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.
Definition
ChEBI: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclo xygenase (COX) inhibitors, SC-560 is selective for COX-1.
Biological Activity
Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.009 and 6.3 μ M for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B 2 , gastric PGE 2 and dermal PDE 2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo . Orally active.
Biochem/physiol Actions
SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID). It is a lipophilic, diaryl heterocyclic compound. SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV). It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.
in vitro
preincubation of cox-1 with sc-560 inhibited the conversion of arachidonic acid to pge2 in a concentration-dependent manner [1]. sc-560 was necessary to sustain a reduced basal level of pgi2 for an extended period. sc-560 inhibits cell proliferation and accelerates apoptosis which results in attenuated tumor growth [2].
in vivo
oral dosing with either 10 or 30 mg/kg sc-560 1 hr before assay completely inhibited cox-1-derived platelet thromboxane b2, gastric pge2, and dermal pge2 production [1]. sc-560 can suppress ovarian surface epithelial tumor growth. tumor growth was suppressed in allografted mice treated with sc-560 for a longer period, but the reduction in tumor growth was less dramatic than the short-term treated [2].
IC 50
0.009 μm for cox-1; 6.3 μm for cox-2
storage
Store at +4°C
References
[1] daikoku t, wang d, tranguch s, morrow jd, orsulic s, dubois rn, dey sk. cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. cancer res. 2005 may 1;65(9):3735-44.
[2] christopher j. smith, yan zhang, carol m. koboldt, jerry muhammad, ben s. zweifel, alex shaffer, john j. talley, jaime l. masferrer, karen seibert, peter c. isakson. pharmacological analysis of cyclooxygenase-1 in inflammation. proc natl acad sci u s a. 1998 oct 27; 95(22): 13313–13318.
SC-560 Preparation Products And Raw materials
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View Lastest Price from SC-560 manufacturers
- Product
- SC-560 188817-13-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09