(1S,2R)-(-)-cis-1-Amino-2-indanol

ChemicalBook > CAS DataBase List > (1S,2R)-(-)-cis-1-Amino-2-indanol

(1S,2R)-(-)-cis-1-Amino-2-indanol

Reaction

Product Name: (1S,2R)-(-)-cis-1-Amino-2-indanol
CAS No.: 126456-43-7
Chemical Name: (1S,2R)-(-)-cis-1-Amino-2-indanol
Synonyms: (1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL;(1S,2R)-1-AMINO-2-INDANOL;(1S,2R)-CIS-1-AMINO-2-INDANOL;(1S,2R)-(-)-1-AMINO-2-INDANOL;CIS-(1S,2R)-1-AMINO-2-INDANOL;(1S;3aR;(1S,2R) -(−KT-1-Amino-2-indanol-0001;5R)-LGH447 dihydrochloride
CBNumber: CB6417161
Molecular Formula: C9H11NO
Formula Weight: 149.19
MOL File: 126456-43-7.mol

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(1S,2R)-(-)-cis-1-Amino-2-indanol Property

Melting point:: 118-121 °C(lit.)
alpha: -62 º (c=0.5, CHCl3)
Boiling point:: 270.27°C (rough estimate)
Density: 1.0753 (rough estimate)
refractive index: 1.5760 (estimate)
RTECS: NK7525500
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
pka: 14.79±0.40(Predicted)
form: Powder
color: White to light beige
optical activity: [α]20/D 61°, c = 0.5 in chloroform
Water Solubility: slightly soluble
Sensitive: Air Sensitive
BRN: 4292559
InChIKey: LOPKSXMQWBYUOI-BDAKNGLRSA-N
CAS DataBase Reference: 126456-43-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
RIDADR: 3259
WGK Germany: 3
F: 10-23
TSCA: No
HazardClass: 8
HS Code: 29052900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 440833
Product name: (1S,2R)-(?)-cis-1-Amino-2-indanol
Purity: 99%
Packaging: 1g
Price: $26
Updated: 2024/03/01

Sigma-Aldrich

Product number: 440833
Product name: (1S,2R)-(?)-cis-1-Amino-2-indanol
Purity: 99%
Packaging: 5g
Price: $27.1
Updated: 2024/03/01

TCI Chemical

Product number: A1624
Product name: (1S,2R)-(-)-1-Amino-2-indanol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: A1624
Product name: (1S,2R)-(-)-1-Amino-2-indanol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $131
Updated: 2024/03/01

Alfa Aesar

Product number: H32066
Product name: (1S,2R)-(-)-cis-1-Amino-2-indanol, 97%
Packaging: 5g
Price: $146.65
Updated: 2024/03/01

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(1S,2R)-(-)-cis-1-Amino-2-indanol Chemical Properties,Usage,Production

Reaction

Ligand component used in the chromium-catalyzed highly selective asymmetric ene reactions between aryl aldehydes and alkoxy- and silyloxyalkenes.
Ligand component for the chromium-catalyzed highly enantioselective o inverse-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes.
Ligand component for the magnesium-catalyzed conjugate addition reaction of 1,3-dicarbonyl compounds to nitroalkenes.
Component for stereoselective asymmetric 6π-azaelectrocyclization through the reaction between the (E)-3-
carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives.
Ligand component for palladium-catalzyed asymmetric azaelectrocyclization for the preparation of 2,4-
disubstituted chiral 1,2,5,6-tetrahydropyridines.
Component for organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to β,γ -Unsaturated α-keto esters.
N-Sulfinyl urea organocatalyst component for enantioselective aza-henry reaction.
Component for organocatalytic enantioselective additions of indoles to nitroalkenes.

Chemical Properties

white to light yellow crystal powder

Uses

1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:

(-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
(R_S,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.

Uses

(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).

General Description

(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.

(1S,2R)-(-)-cis-1-Amino-2-indanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (1S,2R)-(-)-cis-1-Amino-2-indanol manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-07

Hebei Mojin Biotechnology Co., Ltd

Product: (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price: US $100.00/kg
Min. Order: 25kg
Purity: 99.99%
Supply Ability: 200ton
Release date: 2023-07-28

Henan Aochuang Chemical Co.,Ltd.

Product: (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

126456-43-7, (1S,2R)-(-)-cis-1-Amino-2-indanolRelated Search:

Aminopyrine Sulfamic acid 2-Indanol Glycine 4-Amino-benzenesulfonic acid monosodium salt EC 2.6.1.2 6-Aminocaproic acid Acetaminophen ALTRENOGEST 2-Aminophenol Tris(hydroxymethyl)aminomethane Glucosamine Indinavir tert-Butanesulfinamide TERT-BUTYLSULFONAMIDE N-[N,O-ISOPROPYLIDENE-(2R)-HYDROXY INDAN-(1S)-YL]-(2R)-BENZYL-(4S,5)-EPOXY PENTANAMIDE [1(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide 3-(CHLOROMETHYL)PYRIDINE

5R)-LGH447 dihydrochloride

(1S,2R)-(-)-cis-1-Amino-2-hydroxyindane 126456-43-7 (1S,2R)-(-)-cis-1-Amino-2-indanol

(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7

(1S,2R)-(-)-cis-1-Amino-2-indanol,99%

(1S, 2R)-Trans-1-AMino-2-indanol

(1S,2R)-(-)-1-Amino-2,3-dihydro-1H-inden-2-ol, (1S,2R)-(-)-1-Aminoindan-2-ol

(1S,2R)-1-Amino-2,3-dihydro-inden-2-ol

(1S,2R)-(-)-cis-1-Amino-2-indanol ,98%

(1S

2R)-(-)-cis-1-AMino-2-indanol

3aR

7aR)-1-((S)-1-(3-(tert-butyldiMethylsilyloxy)-3-Methylbutoxy)ethyl) -7a-Methylhexahydro-1H-inden-4(2H)-one

KT-1-Amino-2-indanol-0001

(1S,2R)-(-)-cis-1-Amino-2-indanol (1S,2R)-(-)-cis-1-Amino-2-hydroxyindane

(1S,2R)-(-)-1-Amino-2-indanol, >=98%

(1S,2R)-1-Amino-2-indanol,99%e.e.

(1S,2R)-(-)-CIS-1-AMINO-2-HYDROXYINDANE

(1S,2R)-(-)-CIS-1-AMINO-2-INDANOL

(1S,2R)-CIS-1-AMINO-2-INDANOL

(1S,2R)-(-)-CIS-1-AMINOINDAN-2-OL

(1S,2R)-(+)-CIS-1-AMINOINDAN-2-OL

(1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL

(1S,2R)-(-)-1-AMINO-2-HYDROXYINDAN

(1S,2R)-1-AMINO-2-HYDROXYINDANE

(1S,2R)-(-)-1-AMINO-2-INDANOL

(1S,2R)-1-AMINO-2-INDANOL

(1S,2R)-1-AMINO-INDAN-2-OL

CIS-(1S,2R)-1-AMINO-2-INDANOL

cis-(1S)-Amino-(2R)-indanol

(Is-Cis)L-Amino-2,3-Dihydro-Lh-Inden-2-Ol,IndinavirSulphate,

(IS-cis) l-Amino-2,3-Dihydro-lH-Inden-2-ol

CIS-(1S,2R)-1-AMINO-INDANE-2-OL

(1S,2R)-(1)-cis-1-Amino-2-indanol

(1S,2R)-(-)-cis-1-Aminoindan-2-ol,98%

(1S,2R)-(-)-CIS-1-AMINO-2-INDANOL 99%

(1R,2S)-(-)-cis-a-Amino-2-indanol

(1S,2R)-(-)-1-Amino-2-indanol &gt

1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1S,2R)-

Indinavir Impurity 1 （Indinavir EP Impurity A)

(1S,2R)-(-)-cis-1-Amino-2-indanol USP/EP/BP

(1S,2R)-(-)-cis-1-Amino-2-indanol, 97%,

(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-aminium

(1S,2R)-1-Amino-2-indanol/cis-(1S,2R)-1-Amino-2-indanol

(1S,2R) -(&minus

(1S,2R)-(-) -1-amino-2-indenol

126456-43-7

126456-43-9

C9H11NO

Amino Alcohols (Chiral)

Chiral Building Blocks

Hydrogenation

Organic Building Blocks

Chiral Catalysts, Ligands, and Reagents

Asymmetric Synthesis

Amino Alcohols

Chiral Nitrogen

organic alcohol

Amino Alcohols (Chiral)