Reaction
ChemicalBook > CAS DataBase List > (1S,2R)-(-)-cis-1-Amino-2-indanol

(1S,2R)-(-)-cis-1-Amino-2-indanol

Reaction
Product Name
(1S,2R)-(-)-cis-1-Amino-2-indanol
CAS No.
126456-43-7
Chemical Name
(1S,2R)-(-)-cis-1-Amino-2-indanol
Synonyms
(1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL;(1S,2R)-1-AMINO-2-INDANOL;(1S,2R)-CIS-1-AMINO-2-INDANOL;(1S,2R)-(-)-1-AMINO-2-INDANOL;CIS-(1S,2R)-1-AMINO-2-INDANOL;(1S;3aR;(1S,2R) -(−KT-1-Amino-2-indanol-0001;5R)-LGH447 dihydrochloride
CBNumber
CB6417161
Molecular Formula
C9H11NO
Formula Weight
149.19
MOL File
126456-43-7.mol
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(1S,2R)-(-)-cis-1-Amino-2-indanol Property

Melting point:
118-121 °C(lit.)
alpha 
-62 º (c=0.5, CHCl3)
Boiling point:
270.27°C (rough estimate)
Density 
1.0753 (rough estimate)
refractive index 
1.5760 (estimate)
RTECS 
NK7525500
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
14.79±0.40(Predicted)
form 
Powder
color 
White to light beige
optical activity
[α]20/D 61°, c = 0.5 in chloroform
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
4292559
InChIKey
LOPKSXMQWBYUOI-BDAKNGLRSA-N
CAS DataBase Reference
126456-43-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
RIDADR 
3259
WGK Germany 
3
F 
10-23
TSCA 
No
HazardClass 
8
HS Code 
29052900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440833
Product name
(1S,2R)-(?)-cis-1-Amino-2-indanol
Purity
99%
Packaging
1g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
440833
Product name
(1S,2R)-(?)-cis-1-Amino-2-indanol
Purity
99%
Packaging
5g
Price
$27.1
Updated
2024/03/01
TCI Chemical
Product number
A1624
Product name
(1S,2R)-(-)-1-Amino-2-indanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
A1624
Product name
(1S,2R)-(-)-1-Amino-2-indanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$131
Updated
2024/03/01
Alfa Aesar
Product number
H32066
Product name
(1S,2R)-(-)-cis-1-Amino-2-indanol, 97%
Packaging
5g
Price
$146.65
Updated
2024/03/01
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(1S,2R)-(-)-cis-1-Amino-2-indanol Chemical Properties,Usage,Production

Reaction

  1. Ligand component used in the chromium-catalyzed highly selective asymmetric ene reactions between aryl aldehydes and alkoxy- and silyloxyalkenes.
  2. Ligand component for the chromium-catalyzed highly enantioselective o inverse-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes.
  3. Ligand component for the magnesium-catalyzed conjugate addition reaction of 1,3-dicarbonyl compounds to nitroalkenes.
  4. Component for stereoselective asymmetric 6π-azaelectrocyclization through the reaction between the (E)-3-
  5. carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives.
  6. Ligand component for palladium-catalzyed asymmetric azaelectrocyclization for the preparation of 2,4-
  7. disubstituted chiral 1,2,5,6-tetrahydropyridines.
  8. Component for organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to β,γ -Unsaturated α-keto esters.
  9. N-Sulfinyl urea organocatalyst component for enantioselective aza-henry reaction.
  10. Component for organocatalytic enantioselective additions of indoles to nitroalkenes.



Chemical Properties

white to light yellow crystal powder

Uses

1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:

  • (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
  • Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
  • (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.

Uses

(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).

General Description

(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.

(1S,2R)-(-)-cis-1-Amino-2-indanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,2R)-(-)-cis-1-Amino-2-indanol Suppliers

Americas 1 Belgium 3 Canada 1 China 288 Europe 5 France 1 Germany 5 India 13 Indonesia 1 Ireland 1 Italy 1 Japan 8 Norway 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 14 United States 47 Global 395
TOKYO CHEMICAL INDUSTRY CO., LTD.
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View Lastest Price from (1S,2R)-(-)-cis-1-Amino-2-indanol manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Hebei Mojin Biotechnology Co., Ltd
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $100.00/kg
Min. Order
25kg
Purity
99.99%
Supply Ability
200ton
Release date
2023-07-28
Henan Aochuang Chemical Co.,Ltd.
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10

126456-43-7, (1S,2R)-(-)-cis-1-Amino-2-indanolRelated Search:

Aminopyrine Sulfamic acid 2-Indanol Glycine 4-Amino-benzenesulfonic acid monosodium salt EC 2.6.1.2 6-Aminocaproic acid Acetaminophen ALTRENOGEST 2-Aminophenol Tris(hydroxymethyl)aminomethane Glucosamine Indinavir tert-Butanesulfinamide TERT-BUTYLSULFONAMIDE N-[N,O-ISOPROPYLIDENE-(2R)-HYDROXY INDAN-(1S)-YL]-(2R)-BENZYL-(4S,5)-EPOXY PENTANAMIDE [1(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide 3-(CHLOROMETHYL)PYRIDINE

  • 5R)-LGH447 dihydrochloride
  • (1S,2R)-(-)-cis-1-Amino-2-hydroxyindane 126456-43-7 (1S,2R)-(-)-cis-1-Amino-2-indanol
  • (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
  • (1S,2R)-(-)-cis-1-Amino-2-indanol,99%
  • (1S, 2R)-Trans-1-AMino-2-indanol
  • (1S,2R)-(-)-1-Amino-2,3-dihydro-1H-inden-2-ol, (1S,2R)-(-)-1-Aminoindan-2-ol
  • (1S,2R)-1-Amino-2,3-dihydro-inden-2-ol
  • (1S,2R)-(-)-cis-1-Amino-2-indanol ,98%
  • (1S
  • 2R)-(-)-cis-1-AMino-2-indanol
  • 3aR
  • 7aR)-1-((S)-1-(3-(tert-butyldiMethylsilyloxy)-3-Methylbutoxy)ethyl) -7a-Methylhexahydro-1H-inden-4(2H)-one
  • KT-1-Amino-2-indanol-0001
  • (1S,2R)-(-)-cis-1-Amino-2-indanol (1S,2R)-(-)-cis-1-Amino-2-hydroxyindane
  • (1S,2R)-(-)-1-Amino-2-indanol, >=98%
  • (1S,2R)-1-Amino-2-indanol,99%e.e.
  • (1S,2R)-(-)-CIS-1-AMINO-2-HYDROXYINDANE
  • (1S,2R)-(-)-CIS-1-AMINO-2-INDANOL
  • (1S,2R)-CIS-1-AMINO-2-INDANOL
  • (1S,2R)-(-)-CIS-1-AMINOINDAN-2-OL
  • (1S,2R)-(+)-CIS-1-AMINOINDAN-2-OL
  • (1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL
  • (1S,2R)-(-)-1-AMINO-2-HYDROXYINDAN
  • (1S,2R)-1-AMINO-2-HYDROXYINDANE
  • (1S,2R)-(-)-1-AMINO-2-INDANOL
  • (1S,2R)-1-AMINO-2-INDANOL
  • (1S,2R)-1-AMINO-INDAN-2-OL
  • CIS-(1S,2R)-1-AMINO-2-INDANOL
  • cis-(1S)-Amino-(2R)-indanol
  • (Is-Cis)L-Amino-2,3-Dihydro-Lh-Inden-2-Ol,IndinavirSulphate,
  • (IS-cis) l-Amino-2,3-Dihydro-lH-Inden-2-ol
  • CIS-(1S,2R)-1-AMINO-INDANE-2-OL
  • (1S,2R)-(1)-cis-1-Amino-2-indanol
  • (1S,2R)-(-)-cis-1-Aminoindan-2-ol,98%
  • (1S,2R)-(-)-CIS-1-AMINO-2-INDANOL 99%
  • (1R,2S)-(-)-cis-a-Amino-2-indanol
  • (1S,2R)-(-)-1-Amino-2-indanol &gt
  • 1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1S,2R)-
  • Indinavir Impurity 1 （Indinavir EP Impurity A)
  • (1S,2R)-(-)-cis-1-Amino-2-indanol USP/EP/BP
  • (1S,2R)-(-)-cis-1-Amino-2-indanol, 97%,
  • (1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-aminium
  • (1S,2R)-1-Amino-2-indanol/cis-(1S,2R)-1-Amino-2-indanol
  • (1S,2R) -(&minus
  • (1S,2R)-(-) -1-amino-2-indenol
  • 126456-43-7
  • 126456-43-9
  • C9H11NO
  • Amino Alcohols (Chiral)
  • Chiral Building Blocks
  • Hydrogenation
  • Organic Building Blocks
  • Chiral Catalysts, Ligands, and Reagents
  • Asymmetric Synthesis
  • Amino Alcohols
  • Chiral Nitrogen
  • organic alcohol
  • Amino Alcohols (Chiral)