Reaction
ChemicalBook > CAS DataBase List > (1S,2R)-(-)-cis-1-Amino-2-indanol

(1S,2R)-(-)-cis-1-Amino-2-indanol

Reaction
Product Name
(1S,2R)-(-)-cis-1-Amino-2-indanol
CAS No.
126456-43-7
Chemical Name
(1S,2R)-(-)-cis-1-Amino-2-indanol
Synonyms
(1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL;(1S,2R)-1-AMINO-2-INDANOL;(1S,2R)-CIS-1-AMINO-2-INDANOL;(1S,2R)-(-)-1-AMINO-2-INDANOL;CIS-(1S,2R)-1-AMINO-2-INDANOL;(1S;3aR;(1S,2R) -(−KT-1-Amino-2-indanol-0001;5R)-LGH447 dihydrochloride
CBNumber
CB6417161
Molecular Formula
C9H11NO
Formula Weight
149.19
MOL File
126456-43-7.mol
More
Less

(1S,2R)-(-)-cis-1-Amino-2-indanol Property

Melting point:
118-121 °C(lit.)
alpha 
-62 º (c=0.5, CHCl3)
Boiling point:
270.27°C (rough estimate)
Density 
1.0753 (rough estimate)
refractive index 
1.5760 (estimate)
RTECS 
NK7525500
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
14.79±0.40(Predicted)
form 
Powder
color 
White to light beige
optical activity
[α]20/D 61°, c = 0.5 in chloroform
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
4292559
InChIKey
LOPKSXMQWBYUOI-BDAKNGLRSA-N
CAS DataBase Reference
126456-43-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
RIDADR 
3259
WGK Germany 
3
F 
10-23
TSCA 
No
HazardClass 
8
HS Code 
29052900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440833
Product name
(1S,2R)-(?)-cis-1-Amino-2-indanol
Purity
99%
Packaging
1g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
440833
Product name
(1S,2R)-(?)-cis-1-Amino-2-indanol
Purity
99%
Packaging
5g
Price
$27.1
Updated
2024/03/01
TCI Chemical
Product number
A1624
Product name
(1S,2R)-(-)-1-Amino-2-indanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
A1624
Product name
(1S,2R)-(-)-1-Amino-2-indanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$131
Updated
2024/03/01
Alfa Aesar
Product number
H32066
Product name
(1S,2R)-(-)-cis-1-Amino-2-indanol, 97%
Packaging
5g
Price
$146.65
Updated
2024/03/01
More
Less

(1S,2R)-(-)-cis-1-Amino-2-indanol Chemical Properties,Usage,Production

Reaction

  1. Ligand component used in the chromium-catalyzed highly selective asymmetric ene reactions between aryl aldehydes and alkoxy- and silyloxyalkenes.
  2. Ligand component for the chromium-catalyzed highly enantioselective o inverse-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes.
  3. Ligand component for the magnesium-catalyzed conjugate addition reaction of 1,3-dicarbonyl compounds to nitroalkenes.
  4. Component for stereoselective asymmetric 6π-azaelectrocyclization through the reaction between the (E)-3-
  5. carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives.
  6. Ligand component for palladium-catalzyed asymmetric azaelectrocyclization for the preparation of 2,4-
  7. disubstituted chiral 1,2,5,6-tetrahydropyridines.
  8. Component for organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to β,γ -Unsaturated α-keto esters.
  9. N-Sulfinyl urea organocatalyst component for enantioselective aza-henry reaction.
  10. Component for organocatalytic enantioselective additions of indoles to nitroalkenes.



Chemical Properties

white to light yellow crystal powder

Uses

1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:

  • (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
  • Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
  • (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.

Uses

(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).

General Description

(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.

(1S,2R)-(-)-cis-1-Amino-2-indanol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(1S,2R)-(-)-cis-1-Amino-2-indanol Suppliers

Americas 1 Belgium 3 Canada 1 China 289 Europe 5 France 1 Germany 5 India 13 Indonesia 1 Ireland 1 Italy 1 Japan 8 Norway 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 14 United States 47 Global 396
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
More
Less

View Lastest Price from (1S,2R)-(-)-cis-1-Amino-2-indanol manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Hebei Mojin Biotechnology Co., Ltd
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $100.00/kg
Min. Order
25kg
Purity
99.99%
Supply Ability
200ton
Release date
2023-07-28
Henan Aochuang Chemical Co.,Ltd.
Product
(1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10

126456-43-7, (1S,2R)-(-)-cis-1-Amino-2-indanolRelated Search:

Aminopyrine Sulfamic acid 2-Indanol Glycine 4-Amino-benzenesulfonic acid monosodium salt EC 2.6.1.2 6-Aminocaproic acid Acetaminophen ALTRENOGEST 2-Aminophenol Tris(hydroxymethyl)aminomethane Glucosamine Indinavir tert-Butanesulfinamide TERT-BUTYLSULFONAMIDE N-[N,O-ISOPROPYLIDENE-(2R)-HYDROXY INDAN-(1S)-YL]-(2R)-BENZYL-(4S,5)-EPOXY PENTANAMIDE [1(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide 3-(CHLOROMETHYL)PYRIDINE

  • 5R)-LGH447 dihydrochloride
  • (1S,2R)-(-)-cis-1-Amino-2-hydroxyindane 126456-43-7 (1S,2R)-(-)-cis-1-Amino-2-indanol
  • (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
  • (1S,2R)-(-)-cis-1-Amino-2-indanol,99%
  • (1S, 2R)-Trans-1-AMino-2-indanol
  • (1S,2R)-(-)-1-Amino-2,3-dihydro-1H-inden-2-ol, (1S,2R)-(-)-1-Aminoindan-2-ol
  • (1S,2R)-1-Amino-2,3-dihydro-inden-2-ol
  • (1S,2R)-(-)-cis-1-Amino-2-indanol ,98%
  • (1S
  • 2R)-(-)-cis-1-AMino-2-indanol
  • 3aR
  • 7aR)-1-((S)-1-(3-(tert-butyldiMethylsilyloxy)-3-Methylbutoxy)ethyl) -7a-Methylhexahydro-1H-inden-4(2H)-one
  • KT-1-Amino-2-indanol-0001
  • (1S,2R)-(-)-cis-1-Amino-2-indanol (1S,2R)-(-)-cis-1-Amino-2-hydroxyindane
  • (1S,2R)-(-)-1-Amino-2-indanol, >=98%
  • (1S,2R)-1-Amino-2-indanol,99%e.e.
  • (1S,2R)-(-)-CIS-1-AMINO-2-HYDROXYINDANE
  • (1S,2R)-(-)-CIS-1-AMINO-2-INDANOL
  • (1S,2R)-CIS-1-AMINO-2-INDANOL
  • (1S,2R)-(-)-CIS-1-AMINOINDAN-2-OL
  • (1S,2R)-(+)-CIS-1-AMINOINDAN-2-OL
  • (1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL
  • (1S,2R)-(-)-1-AMINO-2-HYDROXYINDAN
  • (1S,2R)-1-AMINO-2-HYDROXYINDANE
  • (1S,2R)-(-)-1-AMINO-2-INDANOL
  • (1S,2R)-1-AMINO-2-INDANOL
  • (1S,2R)-1-AMINO-INDAN-2-OL
  • CIS-(1S,2R)-1-AMINO-2-INDANOL
  • cis-(1S)-Amino-(2R)-indanol
  • (Is-Cis)L-Amino-2,3-Dihydro-Lh-Inden-2-Ol,IndinavirSulphate,
  • (IS-cis) l-Amino-2,3-Dihydro-lH-Inden-2-ol
  • CIS-(1S,2R)-1-AMINO-INDANE-2-OL
  • (1S,2R)-(1)-cis-1-Amino-2-indanol
  • (1S,2R)-(-)-cis-1-Aminoindan-2-ol,98%
  • (1S,2R)-(-)-CIS-1-AMINO-2-INDANOL 99%
  • (1R,2S)-(-)-cis-a-Amino-2-indanol
  • (1S,2R)-(-)-1-Amino-2-indanol &gt
  • 1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1S,2R)-
  • Indinavir Impurity 1 （Indinavir EP Impurity A)
  • (1S,2R)-(-)-cis-1-Amino-2-indanol USP/EP/BP
  • (1S,2R)-(-)-cis-1-Amino-2-indanol, 97%,
  • (1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-aminium
  • (1S,2R)-1-Amino-2-indanol/cis-(1S,2R)-1-Amino-2-indanol
  • (1S,2R) -(&minus
  • (1S,2R)-(-) -1-amino-2-indenol
  • 126456-43-7
  • 126456-43-9
  • C9H11NO
  • Amino Alcohols (Chiral)
  • Chiral Building Blocks
  • Hydrogenation
  • Organic Building Blocks
  • Chiral Catalysts, Ligands, and Reagents
  • Asymmetric Synthesis
  • Amino Alcohols
  • Chiral Nitrogen
  • organic alcohol
  • Amino Alcohols (Chiral)