1-Aminocyclobutanecarboxylic acid
- Product Name
- 1-Aminocyclobutanecarboxylic acid
- CAS No.
- 22264-50-2
- Chemical Name
- 1-Aminocyclobutanecarboxylic acid
- Synonyms
- 1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID;ACBC;cb1700;AC4C-OH;ACBC-OH;cVal-OH;1,1-ACCB;1-Aminocyclobutaneca;1-Amino-1-carboxycyclobutane;1-amino-cyclobutanecarboxylicaci
- CBNumber
- CB6419246
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 22264-50-2.mol
1-Aminocyclobutanecarboxylic acid Property
- Melting point:
- 261 °C (dec.)(lit.)
- Boiling point:
- 241.1±23.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.38±0.20(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Soluble to 100 mM in water.
- InChI
- InChI=1S/C5H9NO2/c6-5(4(7)8)2-1-3-5/h1-3,6H2,(H,7,8)
- InChIKey
- FVTVMQPGKVHSEY-UHFFFAOYSA-N
- SMILES
- C1(N)(C(O)=O)CCC1
- CAS DataBase Reference
- 22264-50-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- GU1336000
- HazardClass
- IRRITANT
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 652369
- Product name
- 1-Amino-1-cyclobutanecarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $60.57
- Updated
- 2025/07/31
- Product number
- 652369
- Product name
- 1-Amino-1-cyclobutanecarboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $185
- Updated
- 2023/06/20
- Product number
- A3638
- Product name
- 1-Aminocyclobutane-1-carboxylic Acid
- Packaging
- 1G
- Price
- $36
- Updated
- 2025/07/31
- Product number
- A3638
- Product name
- 1-Aminocyclobutane-1-carboxylic Acid
- Packaging
- 5G
- Price
- $108
- Updated
- 2025/07/31
- Product number
- 254526
- Product name
- ACBC
- Packaging
- 25mg
- Price
- $366
- Updated
- 2021/12/16
1-Aminocyclobutanecarboxylic acid Chemical Properties,Usage,Production
Uses
ACBC is an NMDA receptor antagonist acting at the glycine site. It acts as an agonist being an analog of glycine at the NMDA-glycine receptor site. This affects the signal transmission in the CNS.
Uses
1-Aminocyclobutanecarboxylic acid acts as an agonist being an analog of glycine at the NMDA-glycine receptor site. This affects the signal transmission in the CNS.
Definition
ChEBI: 1-AMINOCYCLOBUTANE CARBOXYLIC ACID is a L-alpha-amino acid.
reaction suitability
reaction type: solution phase peptide synthesis
Biological Activity
NMDA receptor antagonist acting at the glycine site.
Synthesis
845621-11-6
22264-50-2
1. 1-carbamoyl-cyclobutanecarboxylic acid (1.43 g, 10.0 mmol, 1 eq.) was dissolved in a water-ice bath under nitrogen protection and 1N aqueous NaOH solution (10 mL, 10.0 mmol, 1 eq.) was added slowly. 2. NaOCl solution (10-13% solution, 9.0 mL, ~15.0 mmol, 1.5 eq.) was added slowly and the reaction mixture was stirred for 1 hour at 5 °C. 3. 10N NaOH solution (2.0 mL, 20 mmol, 2 eq.) was added slowly, keeping the reaction temperature below 20 °C and stirred at 15-25 °C for 3 h. The reaction was monitored by LC-MS. The completion of the reaction was monitored by LC-MS. 4. Quench the reaction with an aqueous solution (3 mL) of Na2S2O3-3H2O (2.48 g, 10 mmol, 1 eq.) at 15 °C and continue stirring for 1 hour. 5. Neutralize the reaction mixture with 12N HCl aqueous solution to pH=7.0. 6. Volatiles were removed by azeotropic distillation with toluene under reduced pressure to give about 9 g of white solid. 7. The solid was extracted with methanol (3 x 30 mL) and 2.0 g of crude product was obtained after evaporation of methanol. 8. By 1H NMR analysis, it was determined that the solid contained 0.81 g of the target product, 1-aminocyclobutanecarboxylic acid (70% yield), and the rest were inorganic salts. 9. Comparison of 1H and 13C NMR data confirmed that the structure of the product was consistent with the standard sample provided by Sumitomo Chemical, Inc.
storage
Room temperature
References
[1] Patent: WO2005/19158, 2005, A1. Location in patent: Page/Page column 18
1-Aminocyclobutanecarboxylic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1-Aminocyclobutanecarboxylic acid manufacturers
- Product
- 1-Aminocyclobutanecarboxylic acid 22264-50-2
- Price
- US $3.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 1-Amino-1-cyclobutanecarboxylic acid 22264-50-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-Aminocyclobutanecarboxylic acid 22264-50-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-08-15