ZM 336372

Product Name: ZM 336372
CAS No.: 208260-29-1
Chemical Name: ZM 336372
Synonyms: CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;Probucol (DH-581);ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372, 10 mM in DMSO;ZM 336372; ZM-336372;ZINC00581684;ZM 336372 - CAS 208260-29-1 - Calbiochem
CBNumber: CB6428631
Molecular Formula: C23H23N3O3
Formula Weight: 389.45
MOL File: 208260-29-1.mol

More

Less

ZM 336372 Property

Boiling point:: 484.4±45.0 °C(Predicted)
Density: 1.298
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: >5mg/mL (warmed)
form: powder
pka: 8.31±0.15(Predicted)
color: white to beige
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

More

Less

Safety

WGK Germany: 3
HS Code: 2924297099

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J65730
Product name: ZM 336372
Packaging: 1mg
Price: $51.9
Updated: 2021/12/16

Alfa Aesar

Product number: J65730
Product name: ZM 336372
Packaging: 5mg
Price: $230
Updated: 2021/12/16

Cayman Chemical

Product number: 10010367
Product name: ZM 336372
Purity: >98%
Packaging: 1mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 10010367
Product name: ZM 336372
Purity: >98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Sigma-Aldrich

Product number: 692000
Product name: ZM 336372 - CAS 208260-29-1 - Calbiochem
Packaging: 1mg
Price: $230
Updated: 2024/03/01

More

Less

ZM 336372 Chemical Properties,Usage,Production

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

Uses

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

Definition

ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides.

References

1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559 2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

ZM 336372 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ZM 336372 Suppliers

Canada 1 China 114 Germany 1 India 2 Japan 2 Switzerland 1 United Kingdom 3 United States 23 Global 147

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Abcam

Tel: --
Fax: --
Email: us.orders@abcam.com
Country: United States
ProdList: 6001
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Exlcusive Chemistry Ltd

Tel: --
Fax: --
Country: United States
ProdList: 446
Advantage: 71

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

BIOMOL INTERNATIONAL, LP

Tel: --
Fax: --
Email: info@biomol.com
Country: United States
ProdList: 1499
Advantage: 77

More

Less

View Lastest Price from ZM 336372 manufacturers

Career Henan Chemical Co

Product: N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE 208260-29-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 96%
Supply Ability: 10kg
Release date: 2019-09-04

208260-29-1, ZM 336372Related Search:

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE ZM223 Z-ORN(BOC)-OH ZPCK ZM 323881 hydrochloride ZM 39923 HCl ZM 241385 ZM 306416 SB216763 ZM 447439 Quizartinib (AC220) ZOTAROLIMUS Z-N-Methyl-D-valine Z-NVA-OH ZM 39923 HYDROCHLORIDE Z-NLE-OH ZM306416

N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE

ZM 336372

Zinc00581684

3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE

3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide

Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-

ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

ZM 336372, >=98%

ZM 336372;ZM-336372

ZM 336372 - CAS 208260-29-1 - Calbiochem

CS-44

ZM 336372; ZM-336372;ZINC00581684

ZM 336372 USP/EP/BP

Probucol (DH-581)

ZM 336372, 10 mM in DMSO

208260-29-1

08260-29-1

C23H23N3O3

Inhibitors

MAPK

A potent and specific inhibitor of the protein kinase c-Raf.

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals