ChemicalBook > CAS DataBase List > PyBOP

PyBOP

Product Name
PyBOP
CAS No.
128625-52-5
Chemical Name
PyBOP
Synonyms
PYBOP;BOPP;BOP REAGENT;((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE;1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate;BYPOP;PYBOP(R)
CBNumber
CB6434717
Molecular Formula
C18H28F6N6OP2
Formula Weight
520.39
MOL File
128625-52-5.mol
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PyBOP Property

Melting point:
154-156 °C (dec.)(lit.)
Density 
1.438 at 20℃
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
2-8°C
solubility 
methanol: 25 mg/mL, clear
form 
Fine Crystalline Powder
color 
White to off-white
Sensitive 
Moisture Sensitive
BRN 
3584612
InChI
InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChIKey
BYCLGHOAELJLOF-UHFFFAOYSA-M
SMILES
[P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F
LogP
-0.3 at 26℃ and pH3.5-3.7
CAS DataBase Reference
128625-52-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-44-36/37/38
Safety Statements 
26-36-24/25-37/39
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
F 
8-10-21
Hazard Note 
Irritant
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51009
Product name
PyBOP
Purity
Novabiochem?
Packaging
25g
Price
$123
Updated
2024/03/01
Sigma-Aldrich
Product number
8.51009
Product name
PyBOP
Purity
Novabiochem?
Packaging
100g
Price
$367
Updated
2024/03/01
Sigma-Aldrich
Product number
12805
Product name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity
purum, ≥97.0% (TLC)
Packaging
1g
Price
$81.9
Updated
2024/03/01
Sigma-Aldrich
Product number
12805
Product name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity
purum, ≥97.0% (TLC)
Packaging
5G
Price
$96
Updated
2024/03/01
Sigma-Aldrich
Product number
12805
Product name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity
purum, ≥97.0% (TLC)
Packaging
25g
Price
$298
Updated
2024/03/01
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PyBOP Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.

Uses

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate (PyBOP) is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

Uses

PyBOP is a reagent for: Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates

Definition

PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) coupling reagent was selected for the peptidic bond formation. This selection was because PyBOP is efficient and could generate less toxic byproducts. PyBOP is an efficient coupling reagent utilized in solid-phase peptide synthesis. It reacts similarly to BOP, but its byproduct is not highly carcinogenic. PyBOP was utilized in the solid-phase synthesis of the tetrapeptide H-Ile-Ala-Leu-Pro-OH on 2-chlorotrityl resin. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations[1].

General Description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

References

[1] Maharani, R. et al. “Good coupling performance of PyBOP in the solid-phase synthesis of tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH2.” 2017. 0.

PyBOP Preparation Products And Raw materials

Raw materials

Preparation Products

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PyBOP Suppliers

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View Lastest Price from PyBOP manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Watson Biotechnology Co.,Ltd
Product
PyBOP Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-09-23
Hebei Weibang Biotechnology Co., Ltd
Product
Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price
US $25.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.5%
Supply Ability
100 mt
Release date
2024-11-20

128625-52-5, PyBOPRelated Search:

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride DEPBT TSTU 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Diphenylphosphoryl azide 1H-Benzotriazole Hexafluorophosphoric acid Potassium hexafluorophosphate Lithium hexafluorophosphate Sodium hexafluorophosphate Hexafluorophosphate TRIS(DIETHYLAMINO)PHOSPHINE 1-Hydroxybenzotriazole hydrate 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Hexamethylphosphorous triamide Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

  • pybop?/td>
  • BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHYLAMINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE)
  • (BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
  • BENZOTRIAZOL-1-YL-OXYTRIPYRROLIDINPHOSPHONIUM HEXAFLUOROPHOSPHATE
  • Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-DIMETHYLAMINOPHOPHONIUM
  • BENZOTRIAZOL-1-YLOXYTRIS(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOPHONIUM HEXAFLUOROPHOSPHATE
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRRORIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • BOPP
  • BOP REAGENT
  • HEXAFLUOROPHOSPHATE BOP
  • CASTROS REAGENT
  • CASTRO'S REAGENT
  • 1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
  • PYBOP
  • PYBOP(R)
  • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluoroph
  • Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%
  • PYBOP(R),99%
  • (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate,PyBOP
  • Benzotriazol-1-yl-ox
  • (Benzotriazol-1-yloxy)tripyrrolidinophosphonium he
  • 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%
  • PyBOP (OR) Benzotriazol-1-yloxy tripyrrolidinophosphoniuM hexafluorophosphate
  • PYBOP, 99% 5GR
  • ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V)
  • [(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate
  • (1H-Benzotriazol-1-yloxy)(diMethylaMino)di(pyrrolidin-1-yl)phosphoniuM
  • Phosphorus(1+),[1-(hydroxy-kO)-1H-benzotriazolato]tri-1-pyrrolidinyl-,(T-4)-, hexafluorophosphate(1-) (1:1)
  • (1H-1,2,3-benzotriazol-1-yloxy)tris(pyrrolidin-1-yl)phosphanium
  • BENZOTRIAZOL-1-YL-OXYTRIPYRROLIDINO-PHOS PHONIUM
  • (BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM F6 PHOSPHATE
  • PYBOP [BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE]
  • Benzotriazol-1-yloxytris(pyrrolidino)phosphoniumh
  • Benzotriazol-1-yloxytris-(pyrrolidino)-phosphonium
  • Benzotriazol-1-yloxytripyrroli
  • Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphateBenzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
  • Benzotriazol-1-yloxytris(pyrrolidino)phosphonium Hexafluorophosphate (PyBOP)
  • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphat
  • PYBOP ((1H-BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUMHEXAFLUOROPHOSPHATE)
  • Benzotriazole-1-ly-oxy-tris-pyrrolidinophosphonium hexafluorphosphate
  • 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
  • Benzotriazol-1-yl-oxytrispyrrolidinophosphonium hexafluorophosphate, 97+%
  • Benzotriazole-1-yl-oxy-trispyrrolidinophosphonium hexafluorophosphate ,99%
  • (Benzotriazol-1-yloxy)tripyrrolidinophosphoniuM hexafluorophosphate 98%
  • 1H-Benzotriazol-1-yloxytripyrrolidinophosphoniuM hexafluorophosphate, 98.0%(LC)
  • 1 h benzotriazole - 1 - three pyrrole alkyl six fluoride phosphate PyBOP base oxygen
  • enzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
  • (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate≥ 99% (HPLC)
  • PyBOP Novabiochem
  • 1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate
  • Unable to generate chemical name
  • BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHY
  • Benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate, 99%, for synthesis