1H-Benzimidazole-5-carboxylic acid

Product Name: 1H-Benzimidazole-5-carboxylic acid
CAS No.: 15788-16-6
Chemical Name: 1H-Benzimidazole-5-carboxylic acid
Synonyms: 1H-benzo[d]iMidazole-5-carboxylic acid;1H-Benzo[d]iMidazole-6-carboxylic acid;5-BENZIMIDAZOLECARBOXYLIC ACID;AURORA 9842;AKOS BBS-00000435;BenziMidazole-5-acid;OTAVA-BB BB7014211630;5-CARBOXYBENZIMIDAZOLE;4-caboxylic benzimidazole;5-caboxylic benziMidazole
CBNumber: CB6435996
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 15788-16-6.mol

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1H-Benzimidazole-5-carboxylic acid Property

Melting point:: >300 °C (lit.)
Boiling point:: 288.82°C (rough estimate)
Density: 1.3264 (rough estimate)
refractive index: 1.5770 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Powder
pka: 3.10±0.30(Predicted)
color: Green-gray to gray-brown
BRN: 5686
InChI: InChI=1S/C8H6N2O2/c11-8(12)5-1-2-6-7(3-5)10-4-9-6/h1-4H,(H,9,10)(H,11,12)
InChIKey: COYPLDIXZODDDL-UHFFFAOYSA-N
SMILES: C1NC2=CC(C(O)=O)=CC=C2N=1
CAS DataBase Reference: 15788-16-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 296783
Product name: 5-Benzimidazolecarboxylic acid
Purity: 96%
Packaging: 5g
Price: $60.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 296783
Product name: 5-Benzimidazolecarboxylic acid
Purity: 96%
Packaging: 25g
Price: $266
Updated: 2025/07/31

TCI Chemical

Product number: B1763
Product name: 5-Benzimidazolecarboxylic Acid
Purity: >97.0%(T)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: B1763
Product name: 5-Benzimidazolecarboxylic Acid
Purity: >97.0%(T)
Packaging: 25g
Price: $275
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK135442
Product name: 1H-Benzimidazole-5-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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1H-Benzimidazole-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

GREEN-GREY TO GREY-BROWN POWDER

Uses

A benzimidazole derivative that exhibits corrosion inhibiting properties against strong acids.

Uses

5-Benzimidazolecarboxylic acid has been used in the preparation of:

1H-benzoimidazole-5-carboxylic acid benzotriazol-1-yl ester
piperidin-1-yl(1-m-tolyl-1H-benzo[d]imidazol-5-yl)methanone

General Description

Drug-specific monoclonal antibodies were produced against the very small drug hapten, 5-benzimidazolecarboxylic acid.

Synthesis

124-38-9

4887-88-1

15788-16-6

To a solution of 5-bromo-1H-benzimidazole (0.87 g, 4.4 mmol, 1.0 eq.) in anhydrous THF (20 mL) was slowly added 2 M isopropylmagnesium chloride (i-PrMgCl) in a solution of THF (2.2 mL, 4.4 mmol, 1.0 eq.) at 0 °C, keeping the reaction temperature not more than 20 °C. After addition, the clarified solution was continued to be stirred at 0 °C for 5 min. Subsequently, 2.5 M hexane solution (3.5 mL, 8.8 mmol, 2.0 eq.) of n-butyllithium (n-BuLi) was added dropwise over 5 min, controlling the temperature below 20 °C. The reaction mixture was stirred at the same temperature for 30 min. Then, dry carbon dioxide (0.20 g, 4.4 mmol, 1.0 eq.) was added to the reaction system and the mixture was slowly warmed to 20 °C over 30 min. Upon completion of the reaction, the reaction was quenched with deionized water (6 mL). After stirring at 20 °C for 10 min, the organic and aqueous phases were separated. The aqueous phase was extracted once with ethyl acetate (10 mL). The organic phases were combined, filtered through a 0.51 cm silica gel pad and eluted with ethyl acetate (10 mL). The filtrate was concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 3:1) to afford 1H-benzimidazole-5-carboxylic acid (0.5 g, 71% yield) as a brown solid. The product was structurally confirmed by 1H-NMR (600 MHz, DMSO-d6) and 13C-NMR (151 MHz, DMSO-d6).

References

[1] Molecules, 2017, vol. 22, # 11,

1H-Benzimidazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Formic acid 3,4-Diaminobenzoic acid Hydrochloric acid

Preparation Products

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View Lastest Price from 1H-Benzimidazole-5-carboxylic acid manufacturers

Honest Joy Holdings Limited

Product: 1H-Benzimidazole-5-carboxylic acid 15788-16-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.3%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: 1H-Benzimidazole-5-carboxylic acid 15788-16-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

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15788-16-6

46006-36-6

46006-36-5

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pharmacetical

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BENZIMIDAZOLE