ChemicalBook > CAS DataBase List > 4'-Bromoacetanilide

4'-Bromoacetanilide

Product Name
4'-Bromoacetanilide
CAS No.
103-88-8
Chemical Name
4'-Bromoacetanilide
Synonyms
Asepsin;usafdo-40;USAF do-40;ANTISEPSIN;Bromanilide;Bromoanalide;BROMOANILIDE;Bromcantifebrin;Bromoantifebrin;Bromoacetanilide
CBNumber
CB6483098
Molecular Formula
C8H8BrNO
Formula Weight
214.06
MOL File
103-88-8.mol
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4'-Bromoacetanilide Property

Melting point:
165-169 °C(lit.)
Boiling point:
353.4°C (estimate)
Density 
1.72
refractive index 
1.6120 (estimate)
storage temp. 
Store below +30°C.
solubility 
alcohol: moderately soluble
form 
Crystalline Powder or Crystals
pka
14.25±0.70(Predicted)
color 
White to beige or light gray
Water Solubility 
Insoluble
Merck 
14,1399
BRN 
2208091
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
103-88-8(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-(4-bromophenyl)-(103-88-8)
EPA Substance Registry System
Acetamide, N-(4-bromophenyl)- (103-88-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
3
RTECS 
AD9625000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29242998
Toxicity
mouse,LD50,intraperitoneal,250mg/kg (250mg/kg),National Technical Information Service. Vol. AD277-689,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
161659
Product name
4-Bromoacetanilide
Purity
98%
Packaging
25g
Price
$94.5
Updated
2024/03/01
Sigma-Aldrich
Product number
161659
Product name
4-Bromoacetanilide
Purity
98%
Packaging
100g
Price
$333
Updated
2024/03/01
TCI Chemical
Product number
B0534
Product name
4'-Bromoacetanilide
Purity
>98.0%(GC)
Packaging
25g
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
B0534
Product name
4'-Bromoacetanilide
Purity
>98.0%(GC)
Packaging
100g
Price
$158
Updated
2024/03/01
Alfa Aesar
Product number
L02924
Product name
4'-Bromoacetanilide, 98%
Packaging
50g
Price
$40.65
Updated
2024/03/01
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4'-Bromoacetanilide Chemical Properties,Usage,Production

Chemical Properties

4'-Bromoacetanilide is a white to light beige crystalline solid with a melting point of 168°C and a relative density of 1.717. It is soluble in benzene, chloroform, and ethyl acetate, slightly soluble in alcohol and hot water, and insoluble in cold water. This compound can be prepared by brominating acetanilide and is commonly used as an intermediate in organic synthesis.

Uses

4'-Bromoacetanilide is used as an internal standard for phenylurea and the respective metabolic products in oysters. It has also been used as a reagent in the production of a new ligand to form a coordination compex between gadolinium(III) and T=titanium(IV) oxide. It was used in the synthesis of new ligand for anchoring Gd(III) chelates onto TiO2 surface.

Uses

4-Bromoacetanilide was used as internal standard in determination of several phenylurea and triazine herbicides and their transformation products in oyster. It was used in the synthesis of new ligand for anchoring Gd(III) chelates onto TiO2 surface.

Preparation

Preparation of 4'-Bromoacetanilide from Acetanilide.
Principle: Aromatic compounds can be conveniently brominated by the use of brominating agent, which is normally a solution of bromine in acetic acid. Bromination of activated aromatic compounds usually give 2, 4, 6-tribromo derivatives while moderately activating group like anilide give preferably the para bromo product.
Reaction:

Procedure: Dissolve 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 2.5 ml bromine solution in acetic acid (25% w/v). Shake the mixture for 1 h. After 1 h, pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as a solvent).

Synthesis Reference(s)

Canadian Journal of Chemistry, 50, p. 1233, 1972 DOI: 10.1139/v72-193
Synthetic Communications, 23, p. 779, 1993 DOI: 10.1080/00397919308009839

Purification Methods

Crystallise the anilide from aqueous MeOH or EtOH. Purify it by zone refining. [Beilstein 12 IV 1504.]

4'-Bromoacetanilide Preparation Products And Raw materials

Raw materials

Acetic anhydride Sodium bisulfite solution Sodium bicarbonate 4-Bromoaniline

Preparation Products

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View Lastest Price from 4'-Bromoacetanilide manufacturers

Career Henan Chemical Co
Product
4'-Bromoacetanilide 103-88-8
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10TON
Release date
2018-12-18

103-88-8, 4'-BromoacetanilideRelated Search:

2-BENZOYLACETANILIDE 4-Bromoaniline p-Acetotoluidide 2-Bromoaniline 4'-Aminoacetanilide Acetamide Bromoacetyl bromide 4'-Nitroacetanilide 5-Bromoisatin N-(4-BROMO-2-METHYLPHENYL)MALEAMIC ACID N-(4-BROMOPHENYL)-2-CHLOROACETAMIDE 4'-BROMO-2'-NITROACETANILIDE N-Methyl-2-bromoacetanilide,N-Methyl-2-bromoacetanilide 2-METHYL-4-BROMOACETANILIDE,2-METHYL-4-BROMOACETANILIDE 4-Acetyl-2-bromoacetanilide,4-Acetyl-2-bromoacetanilide m-bromoacetanilid 2'-BROMOACETANILIDE 2-ACETAMIDO-5-BROMOTOLUENE

  • Aceto-p-bromoanilide
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  • Bromoacetoanilide
  • Monobromoacetanilide
  • P-BROMOACETANILIDE, 98% (SEE 1735)
  • 4-Bromoacetanylide
  • Acetamide, N-(4-bromophenyl)-
  • p-BROMOACETANILIDE pure
  • 4'-Bromoacetanilide,98%
  • 4-Bromoacetanilide, 98% PS
  • N-Acetyl-4-bromoaniline, N-(4-Bromophenyl)acetamide
  • P-ACETAMIDOPHENYL BROMIDE
  • P-BROMOACETANILIDE
  • N-ACETYL-4-BROMOANILINE
  • N-ACETYL-P-BROMOANILINE
  • N-(4-BROMO-PHENYL)-ACETAMIDE
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  • 1-Bromo-4-acetamidobenzene
  • 4’-bromo-acetanilid
  • 4'-Bromoacetanilide 250
  • Acetamide, N-(p-bromophenyl)-
  • Acetanilide, 4'-bromo-
  • Acetanilide, p-bromo-
  • Bromine acetanilide
  • Para Bromo Acetanilide 98%
  • 4'-Bromoacetanilide &gt
  • 4'-BROMOACETANILIDE FOR SYNTHESIS
  • Parabromoacetanilide
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  • 103-88-8
  • C8H8BrNO
  • BrC6H4NHCOCH3
  • CH3CONHC6H4Br
  • Organic Building Blocks
  • Nitrogen Compounds
  • Protected Amines