Lonidamine

Description References

Product Name: Lonidamine
CAS No.: 50264-69-2
Chemical Name: Lonidamine
Synonyms: dica;lonidamin;af1890;LONIDAMINE;doridamina;Lonidnmine;LONIDAMING;AF-1890：DICA;Lonidamine, >=99%;DICLONDAZOLIC ACID
CBNumber: CB6493965
Molecular Formula: C15H10Cl2N2O2
Formula Weight: 321.16
MOL File: 50264-69-2.mol

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Lonidamine Property

Melting point:: 207-209°C
Boiling point:: 537.9±45.0 °C(Predicted)
Density: 1.4835 (rough estimate)
refractive index: 1.6070 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
pka: 3.00±0.10(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N
CAS DataBase Reference: 50264-69-2(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 60-22-40
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: NK7886000
HS Code: 29339900
Toxicity: LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L4900
Product name: Lonidamine
Purity: mitochondrial hexokinase inhibitor
Packaging: 5mg
Price: $177
Updated: 2024/03/01

Sigma-Aldrich

Product number: L4900
Product name: Lonidamine
Purity: mitochondrial hexokinase inhibitor
Packaging: 25mg
Price: $606
Updated: 2024/03/01

Cayman Chemical

Product number: 14640
Product name: Lonidamine
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 14640
Product name: Lonidamine
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 14640
Product name: Lonidamine
Purity: ≥98%
Packaging: 50mg
Price: $168
Updated: 2024/03/01

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Lonidamine Chemical Properties,Usage,Production

Description

Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/
https://en.wikipedia.org/wiki/Lonidamine

Description

Lonidamine is an antineoplastic agent reportedly effective for the treatment of various cancers, including lung, breast, prostate and brain tumors. Its clinical effect appears to be associated with changes in cellular energy metabolism.

Originator

Angelini (Italy)

Uses

contraceptive, spermicidal

Definition

ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.

brand name

Doridamina

Biological Activity

Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro .

Biochem/physiol Actions

Inhibits the energy metabolism of neoplastic cells by interfering with hexokinase and disrupting uncoupler-stimulated mitochondrial electron transport; damages cell and mitochondrial membranes.

storage

Room temperature

References

1) Gatto?et al. (2002),?Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids; Contraception,?65?277 2) Floridi?et al., (1981),?Effect of Lonidamine on the Energy Metabolism of Ehrlich Ascites Tumor Cells; Cancer Res.,?41?4661 3) Ravagnan?et al. (1999),?Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore; Oncogene,?18?2537 4) Ben-Horin?et al. (1995),?Mechanism of Action of the Antineoplastic Drug Lonidamine: 31P and 13C Nuclear Magnetic Resonance Studies; Cancer Res.?55?2814 5) Nath?et al. (2016),?Mechanism of antineoplastic activity of lonidamine; Biochim.Biophys.Acta Reviews on Cancer?1866?151

Lonidamine Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Isatin Potassium iodide Sodium nitrite 7-Hydroxygranisetron 2,4-Dichlorobenzoyl chloride

Preparation Products

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Lonidamine Suppliers

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View Lastest Price from Lonidamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lonidamine 50264-69-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min HPLC
Supply Ability: 1000G
Release date: 2021-06-24

Hebei Chuanghai Biotechnology Co,.LTD

Product: Lonidamine 50264-69-2
Price: US $9.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-09

Shanghai Biolang Biotechnology Co., Ltd.

Product: Lonidamine 50264-69-2
Price: US $9.90-7.70/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability: 1000kgs
Release date: 2022-02-22

50264-69-2, LonidamineRelated Search:

Indazole-3-carboxylic acid Triphenylphosphine Dichloroethane Thionyl chloride Citric acid Folic acid Hyaluronic acid 2-Phenylphenol Quinclorac Sodium dichloroisocyanurate Ethyl 2-(Chlorosulfonyl)acetate Dichlorodiphenylsilane Voriconazole Ascoric Acid Phenylacetone 1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE 3-METHYL-1H-INDAZOLE 1H-INDAZOLE-3-CARBALDEHYDE

af1890

lonidamin

1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

1H-Indazole-3-carboxylicacid, 1-[(2,4-dichlorophenyl)Methyl]-

1-(2,4-dichlorbenzyl)-indazole-3-carboxylicacid

1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylicaci

Lonidamine (AF1890)

Lonidamine, 99%, mitochondrial hexokinase inhibitor

Lonidamine, >=99%

1-(3,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid

DICLONDAZOLIC ACID

LONIDAMINE

1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID

1-[(2,4-DICHLOROPHENYL)METHYL]-1H-INDAZOLE-3-CARBOXYLIC ACID

dica

doridamina

1-(2,4-Dichlorobenzyl)indazole-3-carboxylic acid

Lonidnmine

1-[（2,4-Dichlorophenyl）methyl]-1H-indazole-3-carboxylic acid, DICA

1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid, Diclondazolic acid

13iclondazolic Acid

AF-1890：DICA

1-((2,4-dichlorophenyl)methyl)-1h-indazole-3-carboxylicaci

1-[(2，4-Dichloropheny1) methyl]-1H-indazole-3-carboxylic acid

Lonidamine USP/EP/BP

LONIDAMING

50264-69-2

C15H10Cl2N2O2

Biochemicals and Reagents

BioChemical

Hexokinase (mitochondrial), cellular respiration, and glycolysis

D to K

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

API

DORIDAMINA

inhibitor

Anti-cancer&immunity