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TETRAHYDROTHIOPYRAN-4-OL 97

Product Name
TETRAHYDROTHIOPYRAN-4-OL 97
CAS No.
29683-23-6
Chemical Name
TETRAHYDROTHIOPYRAN-4-OL 97
Synonyms
thian-4-ol;4-Hydroxythiane;Thiacyclohexane-4-ol;Tetrahydrothiophene-4-ol;Tetrahydro-2H-thiopyran-4-O;Thiopyran-4-ol, tetrahydro-;4-Hydroxytetrahydrothiopyran;TETRAHYDROTHIOPYRAN-4-OL 97;2H-thiopyran-4-ol, tetrahydro-;4-hydroxy-tetrahydro-2H-thiopyran
CBNumber
CB6499679
Molecular Formula
C5H10OS
Formula Weight
118.2
MOL File
29683-23-6.mol
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TETRAHYDROTHIOPYRAN-4-OL 97 Property

Melting point:
47-51 °C (lit.)
Boiling point:
70°C/0.05mmHg(lit.)
Density 
1.148±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to lump
pka
14.56±0.20(Predicted)
color 
White to Almost white
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Safety

RIDADR 
UN 3335
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
540714
Product name
Tetrahydrothiopyran-4-ol
Purity
97%
Packaging
1g
Price
$226
Updated
2023/06/20
TCI Chemical
Product number
T3373
Product name
Tetrahydro-2H-thiopyran-4-ol
Purity
>98.0%(GC)
Packaging
1g
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
T3373
Product name
Tetrahydro-2H-thiopyran-4-ol
Purity
>98.0%(GC)
Packaging
5g
Price
$432
Updated
2025/07/31
TRC
Product number
P991973
Product name
Tetrahydro-2H-thiopyran-4-O
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
P991973
Product name
Tetrahydro-2H-thiopyran-4-O
Packaging
100mg
Price
$60
Updated
2021/12/16
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TETRAHYDROTHIOPYRAN-4-OL 97 Chemical Properties,Usage,Production

General Description

Tetrahydrothiopyran-4-ol is a sulfur containing heterocyclic building block. Tetrahydrothiopyran-4-ol can be synthesized from tetrahydrothiopyran-4-one. It participates in the synthesis of 4-hydroxyl-1-methyltetrahydrothiopyranium iodide.

Synthesis

1072-72-6

29683-23-6

GENERAL METHOD: Tetrahydrothiopyran-4-one (40.10 g, 0.271 mol) was dissolved in methanol (700 mL), and sodium borohydride (15.36 g, 0.406 mol) was added in batches under ice-bath cooling, and the reaction was stirred for 1 hr. (NOTE: the reaction is exothermic and violent). Subsequently, the reaction mixture was continued to be stirred at 20°C for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give a solid residue. To the residue was added a mixture of saturated aqueous sodium bicarbonate (150 mL) and ethyl acetate (250 mL) (Note: the product is soluble in water). After vigorous shaking, the organic layer was separated and the aqueous layer was further extracted with ethyl acetate (4 x 250 mL). All organic layers were combined, dried over anhydrous sodium sulfate and concentrated to dryness under reduced pressure to give the target product tetrahydro-2H-thiopyran-4-ol.

References

[1] Synthetic Communications, 2018, vol. 48, # 17, p. 2198 - 2205
[2] Chemistry - A European Journal, 2018, vol. 24, # 62, p. 16526 - 16531
[3] Bulletin of the Chemical Society of Japan, 1995, vol. 68, # 9, p. 2739 - 2750
[4] Chemical Communications (Cambridge, United Kingdom), 2002, # 10, p. 1070 - 1071
[5] Patent: EP3342765, 2018, A1. Location in patent: Paragraph 0337

TETRAHYDROTHIOPYRAN-4-OL 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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TETRAHYDROTHIOPYRAN-4-OL 97 Suppliers

China 87 India 3 Japan 1 Switzerland 1 United States 8 Global 100
SIGMA-RBI
Tel
--
Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from TETRAHYDROTHIOPYRAN-4-OL 97 manufacturers

Career Henan Chemical Co
Product
TETRAHYDROTHIOPYRAN-4-OL 97 29683-23-6
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

29683-23-6, TETRAHYDROTHIOPYRAN-4-OL 97Related Search:

Tetrahydrothiopyran-4-one Tetrahydrothiophen-3-one Oxan-4-yl 4-methylbenzenesulfonate Tetrahydro-2H-pyran-4-carbonyl chloride Tetrahydro-4-pyranol Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid tetrahydro-2H-thiopyran-4-ol 1,1-dioxide(SALTDATA: FREE) (TETRAHYDRO-THIOPYRAN-4-YL)-ACETALDEHYDE THIAZOLIDINE Tetrahydro-2H-thiopyran-4-amine 2H-Thiopyran-4-methanol, tetrahydro- 4-Amidinotetrahydro-2H-pyran hydrochloride TETRAHYDROFURAN-3-BORONIC ACID Methyl tetrahydro-3-furoate 2-Furamide,tetrahydro-(6CI,7CI) Tetrahydro-2-furancarboxaldehyde

  • TETRAHYDROTHIOPYRAN-4-OL 97
  • 2H-thiopyran-4-ol, tetrahydro-
  • Thiacyclohexane-4-ol
  • thian-4-ol
  • 4-hydroxy-tetrahydro-2H-thiopyran
  • Tetrahydro-2<i>H</i>-thiopyran-4-ol
  • Thiopyran-4-ol, tetrahydro-
  • 4-Hydroxytetrahydrothiopyran
  • 4-Hydroxythiane
  • Tetrahydro-2H-thiopyran-4-O
  • Tetrahydrothiophene-4-ol
  • 29683-23-6
  • Heterocyclic Compounds