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KT5720

Product Name
KT5720
CAS No.
108068-98-0
Chemical Name
KT5720
Synonyms
KT5720;Aids004395;Aids-004395;KT-5720 (KT5720);InSolution? KT5720;Antibiotic KT 5720;PROTEIN KINASE INHIBITOR KT 5720;KT5720 Antibiotic KT 5720;KT5720 - CAS 108068-98-0 - Calbiochem;InSolution KT5720 - CAS 108068-98-0 - Calbiochem
CBNumber
CB6665746
Molecular Formula
C32H31N3O5
Formula Weight
537.61
MOL File
108068-98-0.mol
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KT5720 Property

Boiling point:
715.0±60.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
methanol: 5 mg/mL
form 
powder
pka
11.96±0.40(Predicted)
color 
white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
-
F 
10
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K3761
Product name
KT 5720
Purity
≥98% (HPLC), powder
Packaging
0.1mg
Price
$259
Updated
2024/03/01
Sigma-Aldrich
Product number
420320
Product name
KT5720 - CAS 108068-98-0 - Calbiochem
Purity
A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
Packaging
50μG
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
420323
Product name
InSolution KT5720 - CAS 108068-98-0 - Calbiochem
Packaging
50μg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
420320
Product name
KT5720 - CAS 108068-98-0 - Calbiochem
Purity
A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
Packaging
100μG
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
10011011
Product name
KT 5720
Purity
≥98%
Packaging
50μg
Price
$81
Updated
2024/03/01
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KT5720 Chemical Properties,Usage,Production

Description

Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-specific effects of KT 5720 include inhibition of phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β at concentrations as effective as or more potent than that for inhibition of PKA.

Chemical Properties

White solid

Uses

KT 5720 is a potent, specific and cell-permeable inhibitor of PKA.

Definition

ChEBI: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3- arboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol- -one.

Biological Activity

Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase. Also available as part of the Mixed Kinase Inhibitor Tocriset™ and PKA Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1) Kase et al. (1987), K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Cabell et al. (1993), Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons; Int. J. Dev. Neurosci., 11 357

KT5720 Preparation Products And Raw materials

Raw materials

Preparation Products

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KT5720 Suppliers

China 70 Europe 1 Germany 6 Japan 3 Switzerland 3 United Kingdom 5 United States 22 Global 110
EMMX Biotechnology LLC
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TargetMol Chemicals Inc.
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BOC Sciences
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Aladdin Scientific
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MedChemExpress
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LKT Laboratories, Inc.
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108068-98-0, KT5720Related Search:

Adenosine 3',5'-cyclic monophosphate sodium salt 8-CHLORO-CAMP PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 9-ISOPROPYLCARBAZOLE 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 KT5720 N-Ethyl-3-carbazolecarboxaldehyde 9-CARBAZOLEPROPIONIC ACID K-252C K-252B 11,12-Dihydroindolo[2,3-a]carbazole 1-ethyl-1H-indole-4-carbaldehyde CARBAZOL-9-YL-METHANOL KT-5720 KT5720 in Solution KT5720 (Selective PKA Inhibitor) KT5720 (semi-synthetic derivative of K525a), Selective PKA Inhibitor, 0.5376kD

  • (9R,10S,12S)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, HEXYL ESTER
  • KT5720
  • PROTEIN KINASE INHIBITOR KT 5720
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-
  • (9s,10s,12r)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
  • KT5720 - CAS 108068-98-0 - Calbiochem
  • InSolution KT5720 - CAS 108068-98-0 - Calbiochem
  • KT-5720 (KT5720)
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-I][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10R,12S)-rel-
  • Aids004395
  • Aids-004395
  • KT5720 Antibiotic KT 5720
  • InSolution? KT5720
  • Antibiotic KT 5720
  • 108068-98-0
  • 108067-98-0
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase A (PKA)
  • Kinase/Phosphatase Biology
  • BioChemical
  • antibiotic
  • Cyclic Nucleotide related