L-(-)-Histidinol dihydrochloride

Product Name: L-(-)-Histidinol dihydrochloride
CAS No.: 1596-64-1
Chemical Name: L-(-)-Histidinol dihydrochloride
Synonyms: (S)-B2;(±)-Midodrin;H-HIS-OL 2HCL;L-HISTIDINOL 2 HCL;L-(-)-Histidinol dih;L-HISTIDINE DIHYDROCHLORIDE;L-Histidinol·2hydrochloride;L-HISTIDINOL DIHYDROCHLORIDE;L-Histidinol (hydrochloride);L-histidinol dihydrochloroide
CBNumber: CB6666879
Molecular Formula: C6H13Cl2N3O
Formula Weight: 214.09
MOL File: 1596-64-1.mol

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L-(-)-Histidinol dihydrochloride Property

Melting point:: 198-201 °C (dec.)(lit.)
alpha: -3 º (C=2, H2O 24 ºC)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
form: Crystalline Powder
color: White to slightly beige
BRN: 3914853
InChIKey: FRCAFNBBXRWXQA-XRIGFGBMSA-N
CAS DataBase Reference: 1596-64-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-37/39-36/37-22
WGK Germany: 3
RTECS: NI8260000
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H6647
Product name: L-Histidinol dihydrochloride
Purity: ≥98 (TLC)
Packaging: 1g
Price: $189
Updated: 2024/03/01

Sigma-Aldrich

Product number: H6647
Product name: L-Histidinol dihydrochloride
Purity: ≥98 (TLC)
Packaging: 5g
Price: $741
Updated: 2024/03/01

Cayman Chemical

Product number: 18739
Product name: L-Histidinol (hydrochloride)
Purity: ≥95%
Packaging: 500mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18739
Product name: L-Histidinol (hydrochloride)
Purity: ≥95%
Packaging: 1g
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: H6647
Product name: L-Histidinol dihydrochloride
Purity: ≥98 (TLC)
Packaging: 10mg
Price: $38.1
Updated: 2024/03/01

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L-(-)-Histidinol dihydrochloride Chemical Properties,Usage,Production

Description

L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.

Chemical Properties

white to slightly beige crystalline powder

Uses

A metabolite within Histidine metabolism.

Definition

ChEBI: L-Histidinol dihydrochloride is an aralkylamine.

in vitro

preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].

in vivo

l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

References

[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.

L-(-)-Histidinol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-(-)-Histidinol dihydrochloride Suppliers

Austria 1 Belgium 1 Canada 1 China 93 Germany 2 India 6 Japan 3 South Korea 1 Switzerland 3 United Kingdom 5 United States 31 Global 147

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View Lastest Price from L-(-)-Histidinol dihydrochloride manufacturers

Hebei Duling International Trade Co. LTD

Product: L-(-)-Histidinol dihydrochloride 1596-64-1
Price: US $35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-02-27

Career Henan Chemical Co

Product: L-(-)-Histidinol dihydrochloride 1596-64-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

1596-64-1, L-(-)-Histidinol dihydrochlorideRelated Search:

Tris(hydroxymethyl)aminomethane 6-Aminocaproic acid ALTRENOGEST 1-Propanol Glycine Ketorolac tromethamine Fosfomycin tromethamine TRISTEARIN Glycinamide hydrochloride Imidazole Dihydrochloride N'-Methyl-L-histidine methyl ester L-HISTIDINE DIHYDROCHLORIDE Methyl L-histidinate dihydrochloride (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride H-HIS(BZL)-OME 2 HCL D(+)-HISTIDINOL DIHYDROCHLORIDE L-Histidine

L(-)-Histidinol dihydrochloride,99%

(S)-β-amino-1H-imidazole-4-propanol dihydrochloride

L-HISTIDINOL 2 HCL

L-HISTIDINOL DIHYDROCHLORIDE

L-HISTIDINE DIHYDROCHLORIDE

L-BETA-AMINO-1H-IMIDAZOLE-4-PROPANOL DIHYDROCHLORIDE

(L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE

HISTIDINOL Dihydrochloride, L-(RG)

L-Histidinol dihydrochloride,β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride

L-(-)-Histidinol dih

(S)-Histidinol Dihydrochloride

(βS)-β-AMino-1H-iMidazole-5-propanol Hydrochloride

<SC>L</SC>-Histidinol dihydrochloride

L-Histidinol (hydrochloride)

L-Histidinol dihydrochloride≥ 99% (TLC)

H-HIS-OL 2HCL

HISTIDINOL DIHYDROCHLORIDE, L-

(S)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE

S(+)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE

(S)-2-AMINO-3-(1H-IMIDAZOL-4-YL)PROPAN-1-OL DIHYDROCHLORIDE

beta-amino-,dihydrochloride,(s)-1h-imidazole-4-propano

beta-amino-imidazole-4-propanodihydrochloride

beta-aminoimidazole-4-propanoldihydrochloride

(S)-beta-amino-1H-imidazole-4-propanol dihydrochloride

Aminoimidazole-4-propanol dihydrochloride

((L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL)

Imidazole-4-propanol, beta-amino, dihydrochloride.

β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride

L-Histidinol·2hydrochloride

2-amino-3-(1H-imidazol-5-yl)-1-propanol dihydrochloride

1H-Imidazole-5-propanol, β-amino-, hydrochloride (1:2), (βS)-

(S)-2-Amino-3-(1h-imidazol-5-yl)propan-1-ol hcl

L-histidinol dihydrochloroide

L-(-)-Histidinol dihydrochloride USP/EP/BP

(S)-β-amino-1H-imidazole-4-propanol dihydrochloride

(S)-B2

-amino-1H-imidazole-4-propanol dihydrochloride

(±)-Midodrin

1H-Imidazole-5-propanol, b-amino-, hydrochloride, (S)-

(S)-2-Amino-3-(1h-imidazol-5-yl)propan-1-ol?dihydrochloride

1596-64-1

1007-422-7

C6H11N3OHCl

AMINE

Peptide Synthesis

Specialty Synthesis

Metabolic Libraries

Metabolomics

Amino Acid Derivatives

Amino Acid Library

BioChemical

Amino Alcohols

Chiral Reagents

Heterocycles

Metabolites & Impurities

Amino hydrochloride