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L-(-)-Histidinol dihydrochloride

Product Name
L-(-)-Histidinol dihydrochloride
CAS No.
1596-64-1
Chemical Name
L-(-)-Histidinol dihydrochloride
Synonyms
(S)-B2;(±)-Midodrin;H-HIS-OL 2HCL;L-HISTIDINOL 2 HCL;L-(-)-Histidinol dih;L-HISTIDINE DIHYDROCHLORIDE;L-Histidinol·2hydrochloride;L-HISTIDINOL DIHYDROCHLORIDE;L-Histidinol (hydrochloride);L-histidinol dihydrochloroide
CBNumber
CB6666879
Molecular Formula
C6H13Cl2N3O
Formula Weight
214.09
MOL File
1596-64-1.mol
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L-(-)-Histidinol dihydrochloride Property

Melting point:
198-201 °C (dec.)(lit.)
alpha 
-3 º (C=2, H2O 24 ºC)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
form 
Crystalline Powder
color 
White to slightly beige
BRN 
3914853
InChIKey
FRCAFNBBXRWXQA-XRIGFGBMSA-N
CAS DataBase Reference
1596-64-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39-36/37-22
WGK Germany 
3
RTECS 
NI8260000
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
1g
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
5g
Price
$741
Updated
2024/03/01
Cayman Chemical
Product number
18739
Product name
L-Histidinol (hydrochloride)
Purity
≥95%
Packaging
500mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
18739
Product name
L-Histidinol (hydrochloride)
Purity
≥95%
Packaging
1g
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
10mg
Price
$38.1
Updated
2024/03/01
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L-(-)-Histidinol dihydrochloride Chemical Properties,Usage,Production

Description

L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.

Chemical Properties

white to slightly beige crystalline powder

Uses

A metabolite within Histidine metabolism.

Definition

ChEBI: L-Histidinol dihydrochloride is an aralkylamine.

in vitro

preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].

in vivo

l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

References

[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.

L-(-)-Histidinol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-(-)-Histidinol dihydrochloride Suppliers

Austria 1 Belgium 1 Canada 1 China 98 Germany 2 India 6 Japan 3 South Korea 1 Switzerland 3 United Kingdom 5 United States 32 Global 153
CHEMICAL LAND21
Tel
--
Fax
--
Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from L-(-)-Histidinol dihydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
L-(-)-Histidinol dihydrochloride 1596-64-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-08
Career Henan Chemical Co
Product
L-(-)-Histidinol dihydrochloride 1596-64-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

1596-64-1, L-(-)-Histidinol dihydrochlorideRelated Search:

Tris(hydroxymethyl)aminomethane 6-Aminocaproic acid ALTRENOGEST 1-Propanol Glycine Ketorolac tromethamine Fosfomycin tromethamine TRISTEARIN Glycinamide hydrochloride Imidazole Dihydrochloride N'-Methyl-L-histidine methyl ester L-HISTIDINE DIHYDROCHLORIDE Methyl L-histidinate dihydrochloride (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride H-HIS(BZL)-OME 2 HCL D(+)-HISTIDINOL DIHYDROCHLORIDE L-Histidine

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