ChemicalBook > CAS DataBase List > 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

Product Name
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
CAS No.
51116-01-9
Chemical Name
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
Synonyms
BR-CGMP, NA;8-BR-CGMP NA;8-BROMO-CGMP NA;Einecs 256-993-8;8-BROMO-CGMP SODIUM;8-BR-CGMP SODIUM SALT;(115974-70-4) 8-AET-cGMP;8-BROMO-CGMP, SODIUM SALT;8-bromo-Cyclic GMP (sodium salt);8 Bromo cGMP sodium,8BromocGMP sodium
CBNumber
CB6687726
Molecular Formula
C10H12BrN5NaO7P
Formula Weight
448.1
MOL File
51116-01-9.mol
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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Property

storage temp. 
-20°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
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Safety

WGK Germany 
3
F 
10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1381
Product name
8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$89.4
Updated
2024/03/01
Sigma-Aldrich
Product number
203820
Product name
Guanosine 3?,5?-cyclic Monophosphate, 8-Bromo-, Sodium Salt
Packaging
25mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
15992
Product name
8-bromo-Cyclic GMP (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15992
Product name
8-bromo-Cyclic GMP (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$74
Updated
2024/03/01
Sigma-Aldrich
Product number
B1381
Product name
8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$179
Updated
2024/03/01
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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Chemical Properties,Usage,Production

Description

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Chemical Properties

White powder

Uses

8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Definition

ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .

storage

Desiccate at -20°C

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Suppliers

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51116-01-9, 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATERelated Search:

Guanosine 5'-monophosphate disodium salt Guanosine ADP 2-BROMO-4-METHYL-1H-IMIDAZOLE 2-BROMO-1-ETHOXYMETHYLIMIDAZOLE 8-BROMO-2'-DEOXYGUANOSINE GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 8-Bromoguanosine 2-Bromo-1-methyl-1H-imidazole 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE 8-BR-CGMP 8-BR-PET-CGMP SODIUM SALT INOSINE-3',5'-CYCLIC PHOSPHATE 8-BROMOGUANINE 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE 8-BROMOHYPOXANTHINE 2'-DCGMP SODIUM SALT 9-((2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl)guanine P-oxide

  • 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,
  • 8-bromoguanosine 3:5-cyclic*monophosphate sodiu
  • 8-Bromoguanosine-3,5-cyclomonophosphate sodium salt
  • Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt
  • 8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
  • 8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5
  • GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT
  • BR-CGMP, NA
  • 8-BR-CGMP NA
  • 8-BR-CGMP SODIUM SALT
  • 8-BROMO-CGMP NA
  • 8-BROMO-CGMP SODIUM
  • 8-BROMO-CGMP, SODIUM SALT
  • 8-BROMOGUANOSINE CYCLIC 3',5'-MONOPHOSPHATE SODIUM SALT
  • 8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
  • 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM
  • 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT
  • 8-BROMOGUANOSINE-3,5-CYCLICMONOPHOSPHATESODIUMSALT,ULTRAPURE
  • Einecs 256-993-8
  • (115974-70-4) 8-AET-cGMP
  • 8-bromo-Cyclic GMP (sodium salt)
  • Guanosine 3,5-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem
  • 8-Bromoguanosine3′,5′-cyclicmonophosphatesodiumsal
  • 8 Bromo cGMP sodium,8BromocGMP sodium
  • 51116-01-9
  • C10H10BrN5NaO7P
  • C10H10BrN5O7PNa
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Biochemicals and Reagents
  • BioChemical
  • G Proteins and Cyclic Nucleotides
  • Cyclic Nucleotide Metabolism
  • Cyclic Nucleotides and Analogs
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Cyclic Nucleotide related
  • Cyclic Nucleotide Metabolism
  • Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
  • G Proteins and Cyclic Nucleotides
  • Protein Kinase G (PKG)
  • Serine/Threonine Kinase Activators