ChemicalBook > CAS DataBase List > Amoxicillin trihydrate

Amoxicillin trihydrate

Product Name
Amoxicillin trihydrate
CAS No.
61336-70-7
Chemical Name
Amoxicillin trihydrate
Synonyms
AMOXYCILLIN TRIHYDRATE;AMOXICILIN TRIHYDRATE;Amoxicillin trihydrate for performance verification CRS;Am 7;Amodex;A-Gram;Ardine;PeniMox;HelvaMox;AmoxiciL
CBNumber
CB6690306
Molecular Formula
C16H21N3O6S
Formula Weight
383.42
MOL File
61336-70-7.mol
More
Less

Amoxicillin trihydrate Property

Melting point:
>200°C (dec.)
alpha 
D20 +246° (c = 0.1)
refractive index 
302 ° (C=0.1, H2O)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water at 3.4mg/ml.
Merck 
14,577
JECFA Number
85
BRN 
7507120
CAS DataBase Reference
61336-70-7(CAS DataBase Reference)
EPA Substance Registry System
Amoxicillin trihydrate (61336-70-7)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
42/43
Safety Statements 
36-36/37-22
WGK Germany 
2
RTECS 
XH8300000
HS Code 
29411000
Toxicity
LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP748
Product name
Amoxicillin impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$238
Updated
2024/03/01
Sigma-Aldrich
Product number
BP019
Product name
Amoxicillin trihydrate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
500MG
Price
$233
Updated
2024/03/01
Sigma-Aldrich
Product number
31586
Product name
Amoxicillin trihydrate
Purity
VETRANAL
Packaging
250mg
Price
$83.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1031503
Product name
Amoxicillin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
A2099
Product name
Amoxicillin Trihydrate
Purity
>98.0%(T)
Packaging
5g
Price
$35
Updated
2024/03/01
More
Less

Amoxicillin trihydrate Chemical Properties,Usage,Production

Description

Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.

Chemical Properties

White to Off-White Solid

Originator

Arnoxil,Bencard,UK,1972

Uses

Semi-synthetic antibiotic related to Penicillin. Antibacterial.

Uses

Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.

Definition

ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.

Manufacturing Process

Ethyl chlorocarbonate (2.2 ml) was added to an ice cold solution of O,N-dibenzyloxycarbonyl-p-oxy-dl-α-aminophenylacetic acid (10 grams) and triethylamine (3.85 ml) in dry acetone (193 ml). The mixture was stirred at 0°C for 5 minutes during which triethylamine hydrochloride precipitated. The suspension was cooled to -30°C and stirred vigorously while adding as rapidly as possible an ice cold solution of 6-aminopenicillanic acid (5.85 grams) in 3% aqueous sodium bicarbonate (193 ml), the temperature of the mixture never being allowed to rise above 0°C. The resulting clear solution was stirred for 30 minutes at 0°C, and then for a further 30 minutes, without external cooling, and finally extracted with diethyl ether (3 x 200 ml) only the aqueous phase being retained.
This aqueous solution was brought to pH 2 by the addition of hydrochloric acid and the 6-(O,N-dibenzyloxycarbonyl-p-oxy-dl-α- aminophenylacetamido)penicillanic acid so liberated was extracted into diethyl ether (50 ml and 2 portions of 30 ml). The ether phase was washed with water (3 x 5 ml) and the water washings were discarded.
Finally, the penicillin was converted to the sodium salt by shaking the ether solution with sufficient 3% sodium bicarbonate to give a neutral aqueous phase, separating the latter and evaporating it at low pressure and temperature below 20°C. The product was finally dried over phosphorus pentoxide in vacuo to give sodium 6-(O,N-dibenzyloxycarbonyl-p-oxy-dl-α- aminophenylacetamido)-penicillanate (9.2 grams).
A suspension of palladium on calcium carbonate (36 grams of 5%) in water (150 ml) was shaken in an atmosphere of hydrogen at room temperature and atmospheric pressure for 1 hour. A neutral solution of sodium 6-(O,Ndibenzyloxycarbonyl- p-oxy-dl-α-aminophenylacetamido)penicillanate (9 grams) in water (100 ml) was then added and shaking in hydrogen was resumed for one hour. The suspension was then filtered and the collected catalyst was washed well with water without being allowed to suck dry between washings. The combined filtrate and washings were then brought to pH 6.5 with dilute hydrochloric acid and evaporated to dryness at reduced pressure and temperatures below 20°C. The product was finally dried over phosphorus pentoxide in vacuo to give a solid (5.4 grams) containing 6-(phydroxy- dl-α-aminophenylacetamido)penicillanic acid.

brand name

Amoxil (GlaxoSmithKline); Dispermox (Ranbaxy); Larotid (GlaxoSmithKline); Trimox (Apothecon) [Name previously used: Amoxycillin.].

Therapeutic Function

Antibacterial

Contact allergens

Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.

Safety Profile

Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Amoxicillin trihydrate Preparation Products And Raw materials

Raw materials

Isooctanoic acid Pivaloyl chloride Hydrochloric acid Dichloromethane Isopropyl alcohol

Preparation Products

Amoxicillin sodium
More
Less

Amoxicillin trihydrate Suppliers

Americas 1 Australia 2 Austria 1 Belgium 2 Brazil 3 Canada 6 China 326 Czech Republic 2 Egypt 1 Europe 3 France 4 Germany 18 India 110 Indonesia 1 Iran 1 Israel 2 Italy 3 Japan 2 Jordan 1 Mexico 4 Nepal 1 Nigeria 1 Oman 1 Pakistan 1 Philippines 1 Poland 3 South Korea 5 Spain 6 Switzerland 5 The Netherlands 11 Tunisia 1 United Kingdom 16 United States 46 Global 591
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
American International Chemical LLC.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
90
Advantage
58
Sinco Pharmachem Inc.
Tel
--
Fax
--
Email
info@sincopharmachem.com
Country
United States
ProdList
37
Advantage
58
ICC Chemical Corporation (a subsidiary of ICC Industries Inc.)
Tel
--
Fax
--
Email
fkt@iccchem.com
Country
United States
ProdList
113
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
R.J. Chemicals, Inc.
Tel
--
Fax
--
Email
info@rjchemicals.com
Country
United States
ProdList
20
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Genegobio Inc.
Tel
--
Fax
--
Email
mark@genegobio.com
Country
United States
ProdList
195
Advantage
0
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Smithkline Beecham Pharmaceuticals GB
Tel
--
Fax
--
Email
AT.CPA@gsk.com
Country
United States
ProdList
10
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
GLAXOSMITHKLINE LLC
Tel
--
Fax
--
Email
cs.invoicemailbox@gsk.com
Country
United States
ProdList
11
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aakash Chemicals and Dye-Stuffs, Inc.
Tel
--
Fax
--
Email
info@aakashchemicals.com
Country
United States
ProdList
1012
Advantage
54
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
DSM Fine Chemicals Inc.
Tel
--
Fax
--
Country
United States
ProdList
151
Advantage
46
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
More
Less

View Lastest Price from Amoxicillin trihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Amoxicillin Trihydrate 61336-70-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
100.7%
Supply Ability
10MT
Release date
2024-05-22
Apeloa production Co.,Limited
Product
Amoxicillin Trihydrate 61336-70-7
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-05-17
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Amoxicillin Trihydrate 61336-70-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-08-09

61336-70-7, Amoxicillin trihydrateRelated Search:

Dimethyl carbonate Dimethyl ether Dimethyl sebacate Dimethyl sulfide Chlorodimethylphenylsilane N,N-Dimethyl-1,4-phenylenediamine Ampicillin Ampicillin sodium Dimethyl sulfoxide Dimethyl sulfate ETHANE Dimethyl fumarate N,N-Dimethylformamide AMOXICILLIN TRIHYDRATE IMP. I (EP): (2R)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID AMOXICILLIN TRIHYDRATE(FOR SUSPENSION.) Amoxicillin trihydrate for direct compression Penicillin G Ampicillin

  • AmoxycillinTrihydrateBp98
  • AmoxicillineTrihydrate
  • AMOXICILLINE 3-HYDRATE
  • 6-(D-[-]-α-Amino-p-hydroxyphenylacetamido) penicillanic acid trihydrate
  • 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-amino(4-hydroxyphenyl)acetylamino-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-
  • AMOXICILLINTRIHYDRATE,USP
  • amoxicillin soluble powder70%
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2S-(2alpha,5alpha,6beta(S*)))-
  • A-Gram
  • Am 7
  • Amodex
  • Amoksicillin
  • Amoxicillin (200 mg)
  • AMoxicillin Trihydrate CoMpacted / Powder
  • Amoxicillin trihydrate for performance verification
  • Amoxycilline Trihydrate Micronised
  • AMOXICILLIN:3H2O
  • Ardine
  • HelvaMox
  • Pasetocin
  • PeniMox
  • ZaMocillin
  • AMoxicillin trihydrate API
  • Amoxicillin Trihyelrate
  • Amoxicillin trihyrate
  • Amoxicillin (hydrate)
  • (2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
  • Amoxicillin tartrate soluhble powder
  • Amoxyclillin Trihydrate
  • Amoxicillin Trihydrate, CP
  • Amoxicillin Trihydrate, 98%,HPLC
  • 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate,(2s-(2-alpha,5-alpha,6-beta4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci
  • acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate,(2s-(2-alpha,5-alpha,6-beta(s*)
  • alpha-amino-p-hydroxybenzylpenicillintrihydrate
  • brl2333trihydrate
  • 6-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
  • AMOXICILIN TRIHYDRATE
  • AMOXICILLIN TRIHYDRATE
  • AMOXICILLIN T TRIHYDRATE
  • AMOXYCILLIN TRIHYDRATE
  • D-(-)-ALPHA-AMINO-P-HYDROXYBENZYL PENICILLIN TRIHYDRATE
  • AMOXICILLIN TRIHYDRATE VETRANAL, 250 MG
  • AMOXICILLIN TRIHYDRATE EPA(CRM STANDARD)
  • AMOXICILLIN TRIHYDRATE MM(CRM STANDARD)
  • AmoxycillinTrihydrateAmoxycillinTrihydrateBp/Usp
  • AMoxillat
  • AmoxiciL
  • in Trihydrate
  • Amoxicillin trihydrate for performance verification CRS
  • Amoxicillin Trihydrate&gt
  • Amoxicillin Trihydrate Standard
  • Amoxipen trihydrate
  • Moxaline trihydrate
  • (2S,5R,6R)-6-[(2R)-2-amino-2-(4-hydroxyphenyl)ac etamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3. 2.0]heptane-2-carboxylic acid trihydrate
  • Amoxicillin trihydrate USP/EP/BP
  • AMOXICILLIN TRIHYDRADE WITH CLAVULANATE POTASSIUM 4:1
  • (2S,5R,6R)-6-((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
  • Amoxicillin Trihydrate (Amoxycillin)