Sertaconazole nitrate

ChemicalBook > CAS DataBase List > Sertaconazole nitrate

Sertaconazole nitrate

Product Name: Sertaconazole nitrate
CAS No.: 99592-32-2
Chemical Name: Sertaconazole nitrate
Synonyms: SERTACONAZOLE;eno;Zalain;FI-7056;fi-7045;Dermofix;Sertaconazol;Sertaconazole API;Sertaconazole nitrate;Sertaconazole nitrate USP/EP/BP
CBNumber: CB6701774
Molecular Formula: C20H15Cl3N2OS
Formula Weight: 437.77
MOL File: 99592-32-2.mol

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Sertaconazole nitrate Property

Melting point:: 146-147°
Boiling point:: 614.1±55.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 6.68±0.12(Predicted)
color: White to Pale Yellow
CAS DataBase Reference: 99592-32-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb134711
Product name: Sertaconazole nitrate
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134711
Product name: Sertaconazole nitrate
Purity: >99%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18771
Product name: Sertaconazole
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134711
Product name: Sertaconazole nitrate
Purity: >99%
Packaging: 1g
Price: $1504.5
Updated: 2021/12/16

AHH

Product number: API-1214
Product name: Sertaconazole nitrate
Purity: 98%
Packaging: 1g
Price: $810
Updated: 2021/12/16

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Sertaconazole nitrate Chemical Properties,Usage,Production

Description

Sertaconazole has been developed and launched for the treatment of dermatological fungal infections by Ferrer Internacional S. A. Mylan received FDA approval for sertaconazole nitrate cream for the treatment of athlete's foot (tinea pedis) at the end of 2003.

Uses

An imidazole antifungal agent, inhibits the synthesis of ergosterol, an essential cell wall component of fungi.

Definition

ChEBI: 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether, a member of imidazoles and a member of 1-benzothiophenes.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as yeasts and dermatophytes. New formulations for the treatment of vaginal mycoses are in development.

Antimicrobial activity

Sertaconazole is a rather new broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi. It also has excellent activity against pathogenic yeasts.

Synthesis

2,4-Dichloro acetophenone 169 was brominated at low temperature to give bromide intermediate 170, which was used without isolation. To the same pot, five-fold excess of imidazole was added to give imidazolylacetophenone 171 in 71% yield from 169. Sodium borohydride was employed to reduce ketone 171 to alcohol 172 in 78% yield. Racemic alcohol 172 was resolved with (-)-DIP-chloride to give its corresponding chiral R-alcohol 173 in 80% yield. Compound 173 was then alkylated with 3-bromomethyl-7-chlorobenzo[b]thiophene (174) in dry DMF in the presence of potassium t-butoxide to give the alkylation product in 68% yield. Finally, 60% nitric acid was used to make sertaconazole mononitrate (XXI) in 89% yield.

Solubility in organics

Fairly soluble in ethanol (1.7 %), chloroform (1.5 %); slightly soluble in acetone (0.95 %); very slightly soluble in noctanol (0.069 %). Practically insoluble in water (< 0.01 %).

Sertaconazole nitrate Preparation Products And Raw materials

Raw materials

Thianaphthene Sodium hydride Hexamethylphosphoramide Silica gel 2-bromomethylbenzene

Preparation Products

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View Lastest Price from Sertaconazole nitrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Sertaconazole nitrate 99592-32-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2021-07-01

Hebei Weibang Biotechnology Co., Ltd

Product: Flunixin meglumine 99592-32-2
Price: US $10.00/KG
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Purity: 99%
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Hebei Mojin Biotechnology Co., Ltd

Product: Flunixin meglumine 99592-32-2
Price: US $0.00/KG
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Release date: 2023-08-28

99592-32-2, Sertaconazole nitrateRelated Search:

(Trifluoromethoxy)benzene 4-(Trifluoromethoxy)aniline Epichlorohydrin 4-Methoxybenzylchloride Miconazole Nitrate Ethyl acetate p-Anisidine Fenticonazole nitrate p-Anisaldehyde 2-Methoxyethanol Econazole nitrate NITRATE Ethylparaben Ethanol Guaiacol 4-Methoxybenzoic acid Anisole 4-Methoxyphenol

1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-i

Dermofix

FI-7056

Zalain

1-[2-[(7-Chlorobenzo[b]thiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[β-[(7-Chlorobenzo[b]thiophene-3-yl)methoxy]-2,4-dichlorophenethyl]-1H-imidazole

Sertaconazol

(+-)-1-(2,4-Dichloro-beta-((7-chlorobenzo(b)thien-3-yl)methoxy)phenethyl)imidazole

1h-imidazole,1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)

7-chloro-3-(1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethoxy-methyl)benzo(b

7-cloro-3-(1-(2,4-diclorofenil)-2-(1h-imidazol-1-il)etoxi-metil)benzo(b)tiof

eno

fi-7045

SERTACONAZOLE

7-CHLORO-3-[1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHOXY-METHYL] BENZO[B]THIOPHENE NITRATE

1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate

1-[2-[(7-Chlorobenzo[b]thien-3-y1)methoxy]-2-(2，4-dichlorophenyl)ethyl]-1H-imidazole

Sertaconazole nitrate

1H-Imidazole, 1-[2-[(7-chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-

Sertaconazole nitrate USP/EP/BP

Sertaconazole API

(RS)-1-(2-((7-chloro-1-benzothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl) -1H-imidazole

99592-32-2

C20H15Cl3N2OSHNO3

C20H15N2OCl3S

Aromatics

Heterocycles

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Sulfur & Selenium Compounds