Synthesis
ChemicalBook > CAS DataBase List > N-Benzylpiperidine-4-carboxaldehyde

N-Benzylpiperidine-4-carboxaldehyde

Synthesis
Product Name
N-Benzylpiperidine-4-carboxaldehyde
CAS No.
22065-85-6
Chemical Name
N-Benzylpiperidine-4-carboxaldehyde
Synonyms
Benzylpiperidine-4-carboxaldehyde;1-Benzylpiperidine-4-carboxaldehyde;N-Benzyl-4-Piperidinecarboxaldehyde95%;N-Benzylpiperidine-4-carboxaldehyde 95%;1-(Phenylmethyl)-4-piperidinecarbaldehyde;1-(Phenylmethyl)-4-piperidinecarboxaldehyde;1-Benzyl-4-piperidinecarboxaldehyde,1-Benzyl-4-formylpiperidine;1-Benzyl-4-formylpiperidine, [(4-Formylpiperidin-1-yl)methyl]benzene;ZERO/005913;RSYY（Avanafil)-1
CBNumber
CB6703107
Molecular Formula
C13H17NO
Formula Weight
203.28
MOL File
22065-85-6.mol
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N-Benzylpiperidine-4-carboxaldehyde Property

Melting point:
145-149 °C
Boiling point:
315.4 °C/760 mmHg
Density 
1.026 g/mL at 25 °C
refractive index 
n20/D 1.537
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Acetone (Slightly), Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Sli
form 
Liquid
pka
8.04±0.10(Predicted)
color 
Clear colorless to pale yellow
Sensitive 
Air Sensitive
InChIKey
SGIBOXBBPQRZDM-UHFFFAOYSA-N
CAS DataBase Reference
22065-85-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-41
Safety Statements 
26-28-36/37/39
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
664081
Product name
N-Benzylpiperidine-4-carboxaldehyde
Purity
95%
Packaging
1g
Price
$67.4
Updated
2023/06/20
Sigma-Aldrich
Product number
664081
Product name
N-Benzylpiperidine-4-carboxaldehyde
Purity
95%
Packaging
5g
Price
$271
Updated
2023/06/20
TCI Chemical
Product number
B3190
Product name
1-Benzyl-4-piperidinecarboxaldehyde
Purity
>96.0%(GC)(T)
Packaging
5g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
B3190
Product name
1-Benzyl-4-piperidinecarboxaldehyde
Purity
>96.0%(GC)(T)
Packaging
25g
Price
$209
Updated
2024/03/01
TRC
Product number
B288620
Product name
1-Benzyl-4-piperidine-carboxaldehyde
Packaging
25g
Price
$540
Updated
2021/12/16
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N-Benzylpiperidine-4-carboxaldehyde Chemical Properties,Usage,Production

Synthesis

A round bottom flask was charged with oxalyl chloride (16.2 g, 0.12 mol), dichloromethane (150 mL) and anhydrous dimethyl sulfoxide (20 mL). Stir the reaction mixture mass in a cryo bath at -70 °C for 15 min. The resulting mixture is charged dropwise with N-benzyl piperidine alcohol 3 (20 g, 0.097 mol), along with triethylamine (24.6 g, 0.24 mol) and continued stirring for the next 15 min. After that, the mass is allowed to attain room temperature overnight, then diluted with dichloromethane (100 mL) and quenched with cold water. The organic layer was washed subsequently with 5 % HCl solution, brine solution, 5 % sodium bicarbonate solution and dried over sodium sulfate. Toluene was removed in vacuo to afford N-Benzylpiperidine-4-carboxaldehyde (19.2 g, 96 %).

Chemical Properties

Colorless Oil

Uses

Reactant for:

  • Stereospecific allylic alkylation
  • Reactions of Grignard reagents with carbonyl compounds
  • Fluorodenitrations and nitrodehalogenations for labeled PET ligands and fluoropharmaceuticals
  • Selective α1 receptor antagonists

Reactant for synthesis of:
  • Donepezil
  • MCH-R1 antagonists

N-Benzylpiperidine-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Benzylpiperidine-4-carboxaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Qiuxian Baitai New Material Co., LTD
Product
N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500ton/Month
Release date
2021-12-21
Career Henan Chemical Co
Product
N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-22

22065-85-6, N-Benzylpiperidine-4-carboxaldehydeRelated Search:

Benzyl chloride DROPERIDOL N-Benzyl-4-piperidone Benzyltrimethylammonium chloride Benzyltriethylammonium chloride Haloperidol Ethyl 1-benzylpiperidine-4-carboxylate Phenylacetone Diphenoxylate 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride 4-Anilino-1-benzyl-4-piperidinecarboxylic acid 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Ethyl1-(4-Bromo-benzyl)-piperidine-4-carboxylate N-BENZYL-4-AMINO-PIPERIDINE-4-CARBOXAMIDE 1-benzyl-4-phenylpiperidine-4-carboxylic acid

  • 1-(Phenylmethyl)-4-piperidinecarbaldehyde
  • 1-Benzyl-4-piperidinecarboxaldehyde,1-Benzyl-4-formylpiperidine
  • N-Benzylpiperidine-4-carboxyaldehyde
  • N-Benzy-4-Piperidine Carboxaldehyde
  • 1-Benzyl-4-formylpiperidine, [(4-Formylpiperidin-1-yl)methyl]benzene
  • 1-Benzylisonipecotaldehyde
  • N-Benzylpiperidine-4-carboxaldehyde 95%
  • N-BENZYLPIPERIDINE-4-CARBOXALDEHYDE
  • 1-BENZYL-PIPERIDINE-4-CARBALDEHYDE
  • Donepezil Impurity 40
  • 1-Benzylpiperidine-4-carboxaldehyde 95%
  • N-benzyl piperdine aldehyde
  • 1-BENZYL-4-PIPERIDINECARBALDEHYDE
  • 1-BENZYL-4-PIPERIDINECARBOXALDEHYDE
  • N-Benzyl-4-Formyl Piperidine
  • 1-Benzy-4-Piperidine Carboxyaldehyde
  • 1-Benzyl-4-Formyl Piperidine
  • 1-Benzy-4-Piperidine Carboxaldehyde
  • 1-benzy-4-piperidine arboxyaldehyde
  • 1-Benzyl-4-PiperidineCarboxyaldehyde
  • N-Benzyl-4-Piperidinecarboxaldehyde95%
  • 1-BENZYLPIPERIDINE-4-CARBALDEHYDE 96%
  • 1-(Phenylmethyl)-4-piperidinecarboxaldehyde
  • 4-Formyl-1-benzylpiperidine
  • N-(Phenylmethyl)piperidine-4-carboxaldehyde
  • N-Benzyl-4-formylpiperidin
  • 1-Benzylpiperidine-4-carboxaldehyde
  • 4-PIPERIDINECARBOXALDEHYDE,1-(PHENYLMETHYL)
  • N‐Benzylisonipecotinaldehyde
  • ZERO/005913
  • 1-Benzyl-4-piperidinecarboxaldehyde &gt
  • N-Benzylpiperidine-4-carbaldehyde
  • -Benzylpiperidine-4-carboxaldehyde
  • 1-benzyl -4-piperdine aldehyde
  • Benzylpiperidine-4-carboxaldehyde
  • RSYY（Avanafil)-1
  • N-Benzylpiperdine carboxaldehyde
  • 1-BENZYL 4 PIPERDINE CARBOXALDEHYDE
  • 1-Benzylpiperidine-4-Carboxaldehyde (BPCA)
  • 22065-85-6
  • 2065-85-6
  • 2447-57-7
  • Building Blocks
  • Piperidines
  • Heterocyclic Building Blocks
  • pharmacetical
  • Alcohol Aldehyde & acid series
  • Piperidine
  • (intermediate of donepezil)
  • Aromatics
  • Heterocycles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines