PYRIDINE-2-CARBOXAMIDE

ChemicalBook > CAS DataBase List > PYRIDINE-2-CARBOXAMIDE

PYRIDINE-2-CARBOXAMIDE

Product Name: PYRIDINE-2-CARBOXAMIDE
CAS No.: 1452-77-3
Chemical Name: PYRIDINE-2-CARBOXAMIDE
Synonyms: PICOLINAMIDE;2-PICOLINAMIDE;Picolinoylamide;PicolinaMide 98%;Picolinamide ,98%;2-Picolinamide>alpha-Picolinamide;TIMTEC-BB SBB008128;2-Carbamoylpyridine;Picolinic acid amide
CBNumber: CB6713827
Molecular Formula: C6H6N2O
Formula Weight: 122.12
MOL File: 1452-77-3.mol

Less

PYRIDINE-2-CARBOXAMIDE Property

Melting point:: 110 °C (dec.)(lit.)
Boiling point:: 143 °C / 20mmHg
Density: 1.2236 (rough estimate)
refractive index: 1.5350 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: pK1: 2.10(+1) (20°C)
color: White to Off-White
BRN: 109617
CAS DataBase Reference: 1452-77-3(CAS DataBase Reference)
EPA Substance Registry System: 2-Pyridinecarboxamide (1452-77-3)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
TSCA: Yes
HS Code: 29333990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 104051
Product name: Picolinamide
Purity: 98%
Packaging: 10g
Price: $49.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 104051
Product name: Picolinamide
Purity: 98%
Packaging: 50g
Price: $237
Updated: 2024/03/01

TCI Chemical

Product number: P0414
Product name: 2-Picolinamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $105
Updated: 2024/03/01

Alfa Aesar

Product number: A15410
Product name: Pyridine-2-carboxamide, 98%
Packaging: 5g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15410
Product name: Pyridine-2-carboxamide, 98%
Packaging: 25g
Price: $169.65
Updated: 2024/03/01

Less

PYRIDINE-2-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO₄.

Uses

A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.

Definition

ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.

Biological Activity

picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.

Biochem/physiol Actions

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.

in vitro

the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].

in vivo

picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].

References

[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.

PYRIDINE-2-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Potassium carbonate Dichloromethane Dimethyl sulfoxide Sodium hydroxide 2-Cyanopyridine Sulfuric acid

Preparation Products

Less

PYRIDINE-2-CARBOXAMIDE Suppliers

Americas 1 Canada 1 China 173 Europe 1 Germany 4 India 8 Japan 4 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 34 Global 233

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19806
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12458
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11660
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4388
Advantage: 65

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

Shanghai Shenyue Chemical Co., Ltd.

Tel: 021-021-52212593 15300879511
Fax: +86 (21) 51062076
Email: sales@nuohey.com
Country: China
ProdList: 6135
Advantage: 60

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4928
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

RiZhao LiDeShi Chemical Co., Ltd.

Tel: 010-51268198
Fax: 010-63833209
Email: leadershipchem@126.com
Country: China
ProdList: 2549
Advantage: 58

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 1352-6885213 15637198702
Fax: 0371-63709726
Email: xpkchem@163.com
Country: China
ProdList: 3998
Advantage: 58

Mei Lan Industrial (Shanghai) Co., Ltd.

Tel: 021-58958189
Fax: 021-58957967
Email: wouchina@126.com
Country: China
ProdList: 2671
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17981
Advantage: 56

Shanghai ideal Industrial Co., Ltd.

Tel: 021-58957966 18930537195
Fax: 021-60899437
Email: wouchina@126.com
Country: China
ProdList: 3033
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13358
Advantage: 58

GuangTuo Chemical (Shanghai) Co., Ltd.

Tel: 021-60899189-8001 18918189673
Fax: 021-60899304
Email: gtchem@126.com
Country: China
ProdList: 2661
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
ProdList: 5877
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10287
Advantage: 55

Changsha Luxing Bio-Chem Technology Co., Ltd.

Tel: 0731-88827538 15873153880
Fax: 0731-88827238
Email: luxingbc@126.com
Country: China
ProdList: 1752
Advantage: 65

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12357
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Chengdu jingzhihuacheng Chemical Technology Co., Ltd.

Tel: 028-37664989 15900794981
Email: jingzhichem@163.com
Country: China
ProdList: 779
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 4111
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9030
Advantage: 60

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 025-5276156 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 4008
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 494
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13351
Advantage: 58

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2844
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: sales@marymebiotech.com
Country: China
ProdList: 3922
Advantage: 58

Less

View Lastest Price from PYRIDINE-2-CARBOXAMIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-13

Hebei Guanlang Biotechnology Co., Ltd.

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-03-08

Career Henan Chemical Co

Product: PYRIDINE-2-CARBOXAMIDE 1452-77-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

1452-77-3, PYRIDINE-2-CARBOXAMIDERelated Search:

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Isonicotinamide Nicotinamide 2,4-Pyridinedicarboxylic acid, 2-Methyl ester Pyridine hydrofluoride 4-AMIDINOPYRIDINE HYDROCHLORIDEPYRIDINE-4-CARBOXIMIDAMIDE HYDROCHLORIDE 3-(2-PYRIDYL)ACRYLIC ACID Nicotinic acid NAD+ β-Nicotinamide Mononucleotide Nicotinamide-N-oxide 3-Cyanopyridine Pyridine-3-sulfonyl chloride hydrochloride PYRIDINE-3-SULFONIC ACID SODIUM SALT PYRIDINE-2,4-DICARBONITRILE Pyridine, 4-(diethylboryl)- Pyridine, 3-(3-ethoxyandrosta-5,16-dien-17-yl)- Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- Picolinamide

alpha-Picolinic acid amide

Picolinic acid amide

Picolinoylamide

Pyridine-2-carboxylicamide

2-PYRIDINECARBOXAMIDE

Isoniazid Impurity I

Nicotinamide EP Impurity C

2-PICOLINAMIDE

PICOLINAMIDE

PYRIDINE-2-CARBOXYLIC ACID AMIDE

PYRIDINE-2-CARBOXAMIDE

TIMTEC-BB SBB008128

Picolinamide ,98%

Picolinamide,2-Pyridinecarboxamide

PicolinaMide 98%

2-Carbamoylpyridine

alpha-Picolinamide

Nicotinamide Impurity 3(Nicotinamide EP Impurity C)

2-Picolinamide&gt

2-Picolinamide, 98%, for synthesis

PYRIDINE-2-CARBOXAMIDE ISO 9001：2015 REACH

2-aminocarbonyl-pyridine

2-Pyridinecarboxamide (9CI, ACI)

pyridine-2-carboxamide (picolinamide)

Nicotinamide Impurity C

Nicotinamide EP Impurity C（Picolinamide）

Pyridin-2-carboxamide

1452-77-3

Heterocyclic Building Blocks

Pyridines

Building Blocks

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocyclic Compounds