PYRIDINE-2-CARBOXAMIDE
- Product Name
- PYRIDINE-2-CARBOXAMIDE
- CAS No.
- 1452-77-3
- Chemical Name
- PYRIDINE-2-CARBOXAMIDE
- Synonyms
- PICOLINAMIDE;2-PICOLINAMIDE;Picolinoylamide;PicolinaMide 98%;Picolinamide ,98%;2-Picolinamide>alpha-Picolinamide;TIMTEC-BB SBB008128;2-Carbamoylpyridine;Picolinic acid amide
- CBNumber
- CB6713827
- Molecular Formula
- C6H6N2O
- Formula Weight
- 122.12
- MOL File
- 1452-77-3.mol
PYRIDINE-2-CARBOXAMIDE Property
- Melting point:
- 110 °C (dec.)(lit.)
- Boiling point:
- 143 °C / 20mmHg
- Density
- 1.2236 (rough estimate)
- refractive index
- 1.5350 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pK1: 2.10(+1) (20°C)
- color
- White to Off-White
- BRN
- 109617
- CAS DataBase Reference
- 1452-77-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Pyridinecarboxamide (1452-77-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 104051
- Product name
- Picolinamide
- Purity
- 98%
- Packaging
- 10g
- Price
- $49.8
- Updated
- 2024/03/01
- Product number
- 104051
- Product name
- Picolinamide
- Purity
- 98%
- Packaging
- 50g
- Price
- $237
- Updated
- 2024/03/01
- Product number
- P0414
- Product name
- 2-Picolinamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- A15410
- Product name
- Pyridine-2-carboxamide, 98%
- Packaging
- 5g
- Price
- $43.65
- Updated
- 2024/03/01
- Product number
- A15410
- Product name
- Pyridine-2-carboxamide, 98%
- Packaging
- 25g
- Price
- $169.65
- Updated
- 2024/03/01
PYRIDINE-2-CARBOXAMIDE Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4.
Uses
A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
Definition
ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.
Biological Activity
picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.
Biochem/physiol Actions
Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.
in vitro
the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].
in vivo
picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].
References
[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.
PYRIDINE-2-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PYRIDINE-2-CARBOXAMIDE Suppliers
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View Lastest Price from PYRIDINE-2-CARBOXAMIDE manufacturers
- Product
- PYRIDINE-2-CARBOXAMIDE 1452-77-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- PYRIDINE-2-CARBOXAMIDE 1452-77-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-13
- Product
- PYRIDINE-2-CARBOXAMIDE 1452-77-3
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04