Trimethyl phosphonoacetate

Product Name: Trimethyl phosphonoacetate
CAS No.: 5927-18-4
Chemical Name: Trimethyl phosphonoacetate
Synonyms: TMPA;METHYL DIMETHYLPHOSPHONOACETATE;Methyl (dimethoxyphosphoryl)acetate;NSC 84262;TRIMETHYL PHOPHONOACETATE;trimethylacetyl phosphate;TriMethyl phosphonoacetat;Trimethylphosphoroacetate;TRIMETHYL PHOSPHONACETATE;RIMETHYL PHOSPHONOACETATE
CBNumber: CB6726270
Molecular Formula: C5H11O5P
Formula Weight: 182.11
MOL File: 5927-18-4.mol

More

Less

Trimethyl phosphonoacetate Property

Melting point:: 242 °C
Boiling point:: 118 °C0.85 mm Hg(lit.)
Density: 1.125 g/mL at 25 °C(lit.)
refractive index: n20/D 1.437(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
Specific Gravity: approximate 1.265ｇ/ml (20℃)
color: Clear colorless to light yellow
Water Solubility: Slightly miscible with water.
BRN: 1865177
LogP: -0.680 (est)
CAS DataBase Reference: 5927-18-4(CAS DataBase Reference)
NIST Chemistry Reference: Trimethyl phosphonoacetate(5927-18-4)
EPA Substance Registry System: Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4)

More

Less

Safety

Safety Statements: 23-24/25
WGK Germany: 3
F: 9
TSCA: Yes
HS Code: 29310095

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T79758
Product name: Trimethyl phosphonoacetate
Purity: 98%
Packaging: 25g
Price: $102
Updated: 2024/03/01

Sigma-Aldrich

Product number: T79758
Product name: Trimethyl phosphonoacetate
Purity: 98%
Packaging: 100g
Price: $125
Updated: 2024/03/01

TCI Chemical

Product number: P1265
Product name: Trimethyl Phosphonoacetate
Purity: >96.0%(GC)
Packaging: 25g
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: P1265
Product name: Trimethyl Phosphonoacetate
Purity: >96.0%(GC)
Packaging: 250g
Price: $243
Updated: 2024/03/01

Alfa Aesar

Product number: A13301
Product name: Trimethyl phosphonoacetate, 98%
Packaging: 25g
Price: $42.65
Updated: 2024/03/01

More

Less

Trimethyl phosphonoacetate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.

Application

Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization

Definition

ChEBI: Trimethyl phosphonoacetate is a phosphonic ester.

Trimethyl phosphonoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

3-METHOXYCARBONYL-3-SULFOLENE

More

Less

Trimethyl phosphonoacetate Suppliers

Americas 1 Belgium 3 China 274 Europe 2 France 3 Germany 9 India 14 Italy 1 Japan 7 Slovakia 1 Switzerland 2 United Kingdom 13 United States 41 Global 371

More

Less

View Lastest Price from Trimethyl phosphonoacetate manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-25

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.6%
Supply Ability: 100000
Release date: 2024-04-23

Hebei Yanxi Chemical Co., Ltd.

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-29

5927-18-4, Trimethyl phosphonoacetateRelated Search:

Methylparaben Vinyl acetate Methyl acetate Amyl acetate POLY(VINYL ACETATE) Trimethyl borate Sodium acetate Tocopheryl acetate Triacetin Ethyl 2-(Chlorosulfonyl)acetate Glatiramer acetate Ethyl acetate Ammonium acetate Bensulfuron methyl Cellulose acetate Linalyl acetate Methyl acrylate Kresoxim-methyl

TriMethyl phosphonoacetate, 98% 25GR

Dimethylphosphonoacetic Acid Methyl Ester Methyl Dimethylphosphonoacetate Phosphonoacetic Acid Trimethyl Ester

TriMethyl phosphonoacetat

Aceticacid, 2-(diMethoxyphosphinyl)-, Methyl ester

Dibenzyloxyphosphoiyl three Methyl acetate

(Carboxymethyl)phosphonic acid trimethyl ester

Dimethyl methoxycarbonylmethylphosphonate~Phosphonoacetic acid trimethyl ester

TMPA

trimethylacetyl phosphate

TRIMETHYL PHOPHONOACETATE

Dimethyl (methoxycarbonyl)methylphosphonate, 98 %

(Dimethoxyphosphinyl)acetic acid methyl

2-(Dimethoxyphosphinyl)acetic acid methyl

Dimethoxyphosphinylacetic acid methyl

Methoxycarbonylmethylphosphonic acid dimethyl ester

(Dimethoxy-phosphoryl)-aceticacidmethylester

Trimethylphosphonoacetate,98%

TriMethyl phosphonoacetate, 98% 100GR

Trimethylphosphonoyl acetate

NSC 84262

Dimethyl methoxycarbonylmethanephosphonate for synthesis

(dimethoxyphosphinyl)-aceticacimethylester

Trimethylphosphoroacetate

METHYL DIMETHYLPHOSPHONOACETATE

Methyl (dimethoxyphosphoryl)acetate

(DIMETHOXYPHOSPHINYL)ACETIC ACID METHYL ESTER

DIMETHYL METHOXYCARBONYLMETHANEPHOSPHONATE

DIMETHYL (METHOXYCARBONYL)METHYLPHOSPHONATE

DIMETHYLPHOSPHONOACETIC ACID METHYL ESTER

ACETIC ACID, (DIMETHOXYPHOSPHINYL)-, METHYL ESTER

PHOSPHONOACETIC ACID TRIMETHYL ESTER

TRIMETHYL PHOSPHONACETATE

TRIMETHYL PHOSPHONOACETATE

TrimethylPhosphonoacetate&gt

Trimethyl phosphonoacetate, 98%, for synthesis

Trimethyl phosphonylacetate

RIMETHYL PHOSPHONOACETATE

Phosphonyl acetate trimethyl ester

5927-18-4

CH3O2POCH2CO2CH3

C5H11O5P

Horner-Wadsworth-Emmons Reagents

Olefination

Synthetic Reagents

Wittig & Horner-Emmons Reaction

Horner-Emmons Reaction

C-C Bond Formation

Horner-Emmons Reaction

Synthetic Organic Chemistry

Wittig & Horner-Emmons Reaction

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

5927-18-4