ChemicalBook > CAS DataBase List > Trimethyl phosphonoacetate
Trimethyl phosphonoacetate
- Product Name
- Trimethyl phosphonoacetate
- CAS No.
- 5927-18-4
- Chemical Name
- Trimethyl phosphonoacetate
- Synonyms
- TMPA;METHYL DIMETHYLPHOSPHONOACETATE;Methyl (dimethoxyphosphoryl)acetate;NSC 84262;TRIMETHYL PHOPHONOACETATE;trimethylacetyl phosphate;TriMethyl phosphonoacetat;Trimethylphosphoroacetate;TRIMETHYL PHOSPHONACETATE;RIMETHYL PHOSPHONOACETATE
- CBNumber
- CB6726270
- Molecular Formula
- C5H11O5P
- Formula Weight
- 182.11
- MOL File
- 5927-18-4.mol
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Trimethyl phosphonoacetate Property
- Melting point:
- 242 °C
- Boiling point:
- 118 °C0.85 mm Hg(lit.)
- Density
- 1.125 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.437(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- Specific Gravity
- approximate 1.265ｇ/ml (20℃)
- color
- Clear colorless to light yellow
- Water Solubility
- Slightly miscible with water.
- BRN
- 1865177
- LogP
- -0.680 (est)
- CAS DataBase Reference
- 5927-18-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Trimethyl phosphonoacetate(5927-18-4)
- EPA Substance Registry System
- Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- T79758
- Product name
- Trimethyl phosphonoacetate
- Purity
- 98%
- Packaging
- 25g
- Price
- $102
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- T79758
- Product name
- Trimethyl phosphonoacetate
- Purity
- 98%
- Packaging
- 100g
- Price
- $125
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1265
- Product name
- Trimethyl Phosphonoacetate
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $52
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1265
- Product name
- Trimethyl Phosphonoacetate
- Purity
- >96.0%(GC)
- Packaging
- 250g
- Price
- $243
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A13301
- Product name
- Trimethyl phosphonoacetate, 98%
- Packaging
- 25g
- Price
- $42.65
- Updated
- 2024/03/01
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Trimethyl phosphonoacetate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.
Application
Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization
Definition
ChEBI: Trimethyl phosphonoacetate is a phosphonic ester.
reaction suitability
reaction type: C-C Bond Formation
Trimethyl phosphonoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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Trimethyl phosphonoacetate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
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- Advantage
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- Japan
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- Country
- Japan
- ProdList
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- Japan
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- Country
- Japan
- ProdList
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- Country
- Japan
- ProdList
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- Advantage
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- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
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View Lastest Price from Trimethyl phosphonoacetate manufacturers
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- Trimethyl phosphonoacetate 5927-18-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-04
hebei hongtan Biotechnology Co., Ltd
- Product
- Trimethyl phosphonoacetate 5927-18-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-25
Hebei Mujin Biotechnology Co.,Ltd
- Product
- Trimethyl phosphonoacetate 5927-18-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-29
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