Trimethyl phosphonoacetate

Product Name: Trimethyl phosphonoacetate
CAS No.: 5927-18-4
Chemical Name: Trimethyl phosphonoacetate
Synonyms: TMPA;METHYL DIMETHYLPHOSPHONOACETATE;Methyl (dimethoxyphosphoryl)acetate;NSC 84262;TRIMETHYL PHOPHONOACETATE;trimethylacetyl phosphate;TriMethyl phosphonoacetat;Trimethylphosphoroacetate;TRIMETHYL PHOSPHONACETATE;RIMETHYL PHOSPHONOACETATE
CBNumber: CB6726270
Molecular Formula: C5H11O5P
Formula Weight: 182.11
MOL File: 5927-18-4.mol

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Trimethyl phosphonoacetate Property

Melting point:: 242 °C
Boiling point:: 118 °C0.85 mm Hg(lit.)
Density: 1.125 g/mL at 25 °C(lit.)
refractive index: n20/D 1.437(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
Specific Gravity: approximate 1.265ｇ/ml (20℃)
color: Clear colorless to light yellow
Water Solubility: Slightly miscible with water.
BRN: 1865177
LogP: -0.680 (est)
CAS DataBase Reference: 5927-18-4(CAS DataBase Reference)
NIST Chemistry Reference: Trimethyl phosphonoacetate(5927-18-4)
EPA Substance Registry System: Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4)

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Safety

Safety Statements: 23-24/25
WGK Germany: 3
F: 9
TSCA: Yes
HS Code: 29310095

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T79758
Product name: Trimethyl phosphonoacetate
Purity: 98%
Packaging: 25g
Price: $105
Updated: 2025/07/31

Sigma-Aldrich

Product number: T79758
Product name: Trimethyl phosphonoacetate
Purity: 98%
Packaging: 100g
Price: $129
Updated: 2025/07/31

TCI Chemical

Product number: P1265
Product name: Trimethyl Phosphonoacetate
Purity: >96.0%(GC)
Packaging: 25g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: P1265
Product name: Trimethyl Phosphonoacetate
Purity: >96.0%(GC)
Packaging: 250g
Price: $231
Updated: 2025/07/31

Usbiological

Product number: 301564
Product name: TmpA
Packaging: 100ug
Price: $382
Updated: 2021/12/16

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Trimethyl phosphonoacetate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.

Application

Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization

Definition

ChEBI: Trimethyl phosphonoacetate is a phosphonic ester.

reaction suitability

reaction type: C-C Bond Formation

Synthesis

The trimethyl phosphonoacetate is prepared from trimethyl phosphite and methyl chloroacetate through Michael Arbuzov rearrangement reaction. The synthetic method satisfies the chemical equations that CH2ClCOOH + CH3OH → CH5ClO2 + H2O, CH5ClO2 + C3H9O3P → C5H11O5P + CH3Cl.

Trimethyl phosphonoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

3-METHOXYCARBONYL-3-SULFOLENE

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Trimethyl phosphonoacetate Suppliers

Americas 1 Belgium 3 CHINA 301 Europe 2 France 3 Germany 9 India 14 Italy 1 Japan 7 Slovakia 1 Switzerland 2 United Kingdom 13 United States 39 Global 396

TCI Chemicals (India) Pvt. Ltd.

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CHEMSWORTH

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Alfa Aesar

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Clearsynth Labs

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Jay Chem Marketing

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ALTAIR ALCHEMY Laboratories

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Saradhi Organics

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Litmus Organics Private Limited

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Central Drug House(P) Ltd.

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A.J Chemicals

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ProdList: 6100
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View Lastest Price from Trimethyl phosphonoacetate manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-20

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: Trimethyl phosphonoacetate 5927-18-4
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

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TriMethyl phosphonoacetate, 98% 25GR

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TriMethyl phosphonoacetat

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(Carboxymethyl)phosphonic acid trimethyl ester

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TMPA

trimethylacetyl phosphate

TRIMETHYL PHOPHONOACETATE

Dimethyl (methoxycarbonyl)methylphosphonate, 98 %

(Dimethoxyphosphinyl)acetic acid methyl

2-(Dimethoxyphosphinyl)acetic acid methyl

Dimethoxyphosphinylacetic acid methyl

Methoxycarbonylmethylphosphonic acid dimethyl ester

(Dimethoxy-phosphoryl)-aceticacidmethylester

Trimethylphosphonoacetate,98%

TriMethyl phosphonoacetate, 98% 100GR

Trimethylphosphonoyl acetate

NSC 84262

Dimethyl methoxycarbonylmethanephosphonate for synthesis

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Trimethylphosphoroacetate

METHYL DIMETHYLPHOSPHONOACETATE

Methyl (dimethoxyphosphoryl)acetate

(DIMETHOXYPHOSPHINYL)ACETIC ACID METHYL ESTER

DIMETHYL METHOXYCARBONYLMETHANEPHOSPHONATE

DIMETHYL (METHOXYCARBONYL)METHYLPHOSPHONATE

DIMETHYLPHOSPHONOACETIC ACID METHYL ESTER

ACETIC ACID, (DIMETHOXYPHOSPHINYL)-, METHYL ESTER

PHOSPHONOACETIC ACID TRIMETHYL ESTER

TRIMETHYL PHOSPHONACETATE

TRIMETHYL PHOSPHONOACETATE

TrimethylPhosphonoacetate&gt

Trimethyl phosphonoacetate, 98%, for synthesis

Trimethyl phosphonylacetate

RIMETHYL PHOSPHONOACETATE

Phosphonyl acetate trimethyl ester

Trimethyl phosphonoacetate, 97%

Phosphoryl acetate trimethyl ester

5927-18-4

CH3O2POCH2CO2CH3

C5H11O5P

Horner-Wadsworth-Emmons Reagents

Olefination

Synthetic Reagents

Wittig & Horner-Emmons Reaction

Horner-Emmons Reaction

C-C Bond Formation

Horner-Emmons Reaction

Synthetic Organic Chemistry

Wittig & Horner-Emmons Reaction

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

5927-18-4